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Tytuł oryginału: Nie koncząca się historia witaminy D.
Tytuł angielski: A never ending story of vitamin D.
Autorzy: Kroszczyński Wojciech, Morzycka Bożena, Morzycki Jacek W.
Źródło: Wiad. Chem. 2002: 56 (9/10) s.793-809, il., sum.
Sygnatura GBL: 310,575

Hasła klasyfikacyjne GBL:
  • endokrynologia
  • onkologia
  • traumatologia i ortopedia
  • dermatologia i wenerologia

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The existence of vitamin D was discovered as a consequence of human disease. Vitamin D deficiency in childhood producers rickets, which is characterized by inadequate calcification of cartilage and bone. In rickets, the whole bony structure is soft and flexible, so that can hardly support the superposed weight of the body. Rickets was common in the 19th century, when the industrial revolution caused change of an agrarian society to an industrial society. The population in larege measure spent much more time inside buildings, which shielded them from ultraviolet light. It was proved than sun light and cod liver oil are equally active in preventing and curing rickets. Further studies led to the discovery of anti-rachitic vitamin D. A deficiency in vitamin D impairs bone formation in growing animals. The precursor of cholecalciferol (vitamin D3) is 7-dehydrocholesterol (provitamin D3) present in the skin. Irradiation of this compound results in the formation of previtamin D3 which spontaneously isomerizes to vitamin D3 (thermal rearrangement). Vitamin D3 is further converted by enzymatic hydroxylation reactions occurring in the liver and kidneys into an active hormone, which was isolated and identified as 1ŕ,25-dihydroxyvitamin D3. Other biologically active metabolities and analogues of vitamin D were also described. The vitamin D endocrine system was primarily recognized for its critical described. The vitamin D endocrine system was primarily recognized for its critical role in calcium and phosphorus homeostasis. The active form of the viutamin, 1ŕ,25-(OH)2D3...

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