Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
Zapytanie:
KREMERS
Liczba odnalezionych rekordów:
1
Przejście do opcji zmiany formatu
|
Wyświetlenie wyników w wersji do druku
1/1
Tytuł oryginału:
Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk.
Autorzy:
Benhamou
Simone,
Lee
Won Jin,
Alexandrie
Anna-Karin,
Boffetta
Paolo,
Bouchardy
Christine,
Butkiewicz
Dorota,
Brockmller
Jurgen,
Clapper
Margie L.,
Daly
Ann,
Dolzan
Vita,
Ford
Jean,
Gaspari
Laura,
Haugen
Aage,
Hirvonen
Ari,
Husgafvel-Pursiainen
Kirsti,
Ingelman-Sundberg
Magnus,
Kalina
Ivan,
Kihara
Masahiro,
Kremers
Pierre,
Le Marchand
Loic,
London
Stephanie J.,
Nazar-Stewart
Valle,
Onon-Kihara
Masako,
Rannug
Agneta,
Romkes
Marjorie,
Ryberg
David,
Seidegard
Janeric,
Shields
Peter,
Strange
Richard C.,
Stcker
Isabelle,
To-Figueras
Jordi,
Brennan
Paul,
Taioli
Emanuela
Źródło:
Carcinogenesis 2002: 23 (8) s.1343-1350, il., tab., bibliogr. 54 poz.
Sygnatura GBL:
312,779
Hasła klasyfikacyjne GBL:
pulmonologia
onkologia
Typ dokumentu:
praca kliniczna
praca opublikowana za granicą
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
Streszczenie angielskie:
Susceptibility to lung cancer may in part be attributable to inter-individual variability in metabolic activation or detopxification of tobacco carcinogens. The glutathione S-transferase M1 (GSTM1) genetic polymorphism has been extensively studied in this context; two recent meta-analyses of case-control studies suggested an association between GSTM1 deletion and lung cancer. At least 15 studies have been published after these overviews. We undertook a new meta-analysis to summarize the results of 43 published case-control studies including 18000 individuals. A slight excess of risk of lung cancer for individuals with the GSTM1 null genotype was found (odds ratio (OR) = 1.17, 95 p.c. confidence interval (CI) 1.07 - 1.27). No evidence of publication bias was found (P = 0.4), however, it is not easy to estimate the extent of such bias and we cannot rule out some degree of publications bias in our rsults. A pooled analysis of the original dsata of about 9500 subjects involved in 21 case-control studies from the international Collaborative Study on genetic Dusceptibility to Environmental Carcinogens (GSEC) data set was performed to assess the role of gsTM1 genotype as a modifier of the effect of smoking on lung cancer risk with adequate power. Analyses revealed no evidence of increased risk of lung cancer among carriers of the GSTM1 null genotype (age-, gender- and center-adjusted OR = 1.08, 95 p.c. CI 0.98 - 1.18) and no evidence of interaction between GSTM1 genotype and either smoking status or cumulative tobacco consumption.
stosując format:
z abstraktem i deskryptorami
z abstraktem
z deskryptorami
skrócony