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Tytuł oryginału: Selected parameters of fibrinolysis system in patients with dermatitis herpetiformis.
Autorzy: Wankiewicz Anna, Iwan-Ziętek Iza, Kotchy Maria, Gwieździński Zenon
Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR189-CR192, tab., bibliogr. 8 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • dermatologia i wenerologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Dermatitis herpetiformis (DH) is a very rare bullous dermatitis of autoimmune origin. It is a sydnrome involving dermal and intestinal pathology, in which vesicopapular skin lesions are accompanied by gluten-dependent enteropathy. The diagnosis of DH is based on immunopathological investigation of unaffected skin bioptate (presence of granular IgA deposits in the upper portions of dermal papillae). Materia/Methods: The study was carried out in a group of 33 patients, including 23 males and 10 females aged 22-78 (mean age 44.7 years). The following fibrinolysis system parameters were determined in the sera of all patients: tissue plasminogen activator concentration (t-PA: Ag), urokinase plasminogen activator concentration (u-PA: Ag), plasminogen activator inhibitor concentration (PAI-Ag), plasminogen level, alpha-2 antiplasmin activity (ŕ-2-AP), plasmin - alpha-2 antiplasmin complexes concentration (PAP). Results: Mean t-PA concentration in DH patients was 5.52 ng/ml, vs.4.8 ng/ml in controls. The respective u-PA concentrations amounted to 0.33 ng/ml, and 0.39 ng/ml. PAI-1 concentration was markedly higher in DH patietns (36.2 ng/ml) than in controls (22.40 ng/ml), whereas plasminogen level was significantly lower (86.0 p.c. vs. 115.9 p.c.). In patients, ŕ-2-AP activity was 92 p.c. and was ower than in controls - 103.4 p.c. DH patients demosntrated also higher concentrations of PAP complexes (327.45 ng/ml) than the control group (203.03 ng/ml). Conclusions: Patietns with DH were found to have lower plasminogen and ŕ-2 antiplasmin levels and increased concentrations of PAP complexes, which indicates increased plasminogenesis n vivo. Increased type 1 plasminogen activator inhibitor level (PAI-1) may reflect a chronic inflammatory condition present in DH patients.

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