Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: KONTUREK
Liczba odnalezionych rekordów: 32



Przejście do opcji zmiany formatu | Wyświetlenie wyników w wersji do druku
1/32

Tytuł oryginału: Intracerebroventricular administration of bacterial lipopolysaccharide prevents the development of acute experimental pancreatitis in the rat.
Autorzy: Jaworek Jolanta, Bonior Joanna, Nawrot Katarzyna, Leja Anna, Sendur Ryszard, Stachura Jerzy, Pawlik Wiesław, Konturek Stanisław
Źródło: Med. Sci. Monitor 2002: 8 (4) s.BR136-BR143, il., tab., bibliogr. 46 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Lipopolysaccharides (LPS) are responsible for septic shock but low doses of LPS reduce pancreatic damage produced by caerulein-induced pancreatitis (CIP) in rats. Leptin, produced by adipocytes attenuates the severity of CIP. The aim of this study was to evaluate the effect of intracerebroventricular (i.c.v) administration of LPS on CIP and plasma leptin level and to investigate the involvement of sensory nerves (SN) in the effects of LPS on CIP. CIP was produced by subcutaneous (s.c.) infusion of caerulein (25 ćg/kg) to conscious rats. SN were deactivated with capsaicin (100 mg/kg s.c.). LPS (0.2, 2, or 20 ćg/rat) were applied to the right cerebral ventricle 30 min prior to CIP. CIP was manifested by an increase in plasma levels of amylase, lipase, leptin and an antiinflammatory interleukin 10 (IL-10), (by 400 p.c., 1000 p.c., 700 p.c. and 50 p.c., respectively), confirmed by histological examination and accompanied by 40 p.c. reduction in pancreatic blood flow. Pretreatment of CIP rats with i.c.v. LPS resulted in significant reduction of CIP accompanied by dose-dependent increase in plasma levels of leptin and IL-10. Deactivation of SN, which by itself failed to affect CIP, completely reversed the beneficial effects of i.c.v. administration of LPS on CIP and reduced plasma leptin and IL-10 concentrations. Pretreatment with LPS given i.c.v. prevents the development of caerulein-induced pancreatitis through the activation of SN and though the release of leptin.

    2/32

    Tytuł oryginału: Oral cavity as a potential source of gastric reinfection by Helicobacter pylori.
    Autorzy: Karczewska Elżbieta, Konturek Joanna E., Konturek Peter C., Cześnikiewicz Marta, Sito Edward, Bielański Władysław, Kwiecień Nina, Obtułowicz Wojciech, Ziemniak Witold, Majka Jolanta, Hahn Eckhart G., Konturek Stanisław J.
    Źródło: Dig. Dis. Sci. 2002: 47 (5) s.978-986, il., tab., bibliogr. 24 poz.
    Sygnatura GBL: 310,037

    Hasła klasyfikacyjne GBL:
  • stomatologia
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Helicobacter pylori (Hp) is a common pathogen colonizing the a gastric mucosa, but some reports indicated that it may also be found in the oral cavity, which could serve as a reservoir of the bacteria and a source of gastric reinfection. Accordingly, we aimed to study whether the oral cavity, particularly gingival pockets, are colonized by Hp and whether it could be the source of gastric reinfection. We studied 329 patients with dyspeptic symptoms (257 with chronic gastritis, 15 with gastric ulcer. and 57 with duodenal ulcer). The [**13C]urea breath test (UBT), gastroscopy, and Hp culture from gastric biopsies were carried out, and material was collected from the oral cavity (gingival pocket) for bacteriological culture and genomic DNA studies. The serum was obtained for anti-Hp IgG and anti-CagA assays and saliva for anti-Hp IgA determination using the ELISA technique. bacteria in material from gingival pockets and biopsies from the corpus and antrum of stomach of 30 DU patients before and after Hp eradication were also examined by PCR technique, using primers specific for 16S rNA. All Hp-positive patients (276) were subjected to one week of triple therapy (omeprazole 2 x 20 mg twice a day, clarithromycin 2 = 500 mg twice a day, and metronidazole 2 x 500 mg twice a day). The measurements descrived above were then repeated at four weeks and six months. Bacterkilogical culture showed the prsence of Hp in the material from oral cavity in about 50 p.c. of patients, whereas UBT, used as a gold standard, revealed gastric Hp infection in about 84 p.c. of these patients...

    3/32

    Tytuł oryginału: Effect of Helicobacter pylori on delay in ulcer healing induced by aspirin in rats.
    Autorzy: Konturek Peter C., Brzozowski Tomasz, Kwiecień Sławomir, Drozdowicz Danuta, Harsch Igor A., Meixner Holger, Stachura Jerzy, Hahn Eckhart G., Konturek Stanisław J.
    Źródło: Eur. J. Pharmacol. 2002: 451 (2) s.191-202, il., tab., bibliogr [37] poz.
    Sygnatura GBL: 312,088

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Helicobacter pylori and nonsteroidal anti-inflammatory drugs (NSAIDs) are major pathogenic factors in peptic ulcer disease but whether these two factors exert synergistic or antagonistic effects on ulcer healing has been a subject of controversy. We compared the effect of aspirin alonne with that of aspirin combined with H. pylori on gastric acid secretion and healing of acetic gastric ulcers in rats. The H. pylori colonization of gastric mucosa was determined by viable H. pylori culture, histology and assessment of bacterial DNA using polymerase chain reaction (PCR). The area of ulcers, gastric blood flow, mucosal generation of prostaglandin E2 and plasma gastrin levels and expression of cyclooxygenase-1, cyclooxygenase-2 and growth factors was determined. Aspirin delayed significantly the healing of chronic gastric ulcers, decreased the gastric blood flow at the ulcer margin and gastric mucosal prostaglandin E2 heneration being without significant influence on gastric acid output H. pylori acquisition that produced moderate gastric inflammation at the ulcer margin delayed significantly the healing of gastric ulcers, decreased significantly both the gastric blood flow at the ulcer margin and the gastric secretion while raising significantly the gastric mucosal prostaglandin E2 generation and plasma gastrin levels. H. pylori infection attenuated the aspirin-induced inhibition of ulcer healing and accompanying fall in the gastric blood flow. Both aspirin and H. pylori up-regulated significantly cyclooxygenase-2 messenger RNA (mRNA)...

    4/32

    Tytuł oryginału: Progastrin and cyclooxygenase-2 in colorectal cancer.
    Autorzy: Konturek Peter C., Bielański Władysław, Konturek Stanisław J., Hartwich Artur, Pierzchalski Piotr, Gonciarz Maciej, Marlicz Krzysztof, Starzyńska Teresa, Zuchowicz Monika, Darasz Zbigniew, G”tze Jens P., Rehfeld Jens F., Hahn Eckhart G.
    Źródło: Dig. Dis. Sci. 2002: 47 (9) s.1984-1991, il., tab., bibliogr. 41 poz.
    Sygnatura GBL: 310,037

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Colorectal cancers (CRCs) are one of the most common forms of cancer in Poland and one of the leading causes of dearh. The tumors have been attributed to genetic, dietary, and other environmemtal factors, but recently factors such as gastrin have also been implicated in the carcinogenesis. The relationship between plasma amidated and nonamidated gastrin in CRCs is controversial. This study was designed to determine the plasma levels of progastrin and amidated gastrin in 50 CRC patients before and 3-6 months after removal of the tumor, to determine the tumor concentrations of these gastrin peptides and the level of expression for gastrin mRNA and gastrin/CCKb receptor mRNA, to examine the expression of cyclooxygenase COX-1 and COX-2 in mRNA in CRC tissue, and to compare the prevalence of Hp and its cytotoxic protein, CagA, and cytokines (TNFŕ, IL-1á, and IL-8) in CRCs, before and after removal of tumor. It was found that thwe CRC, its resection margin, and the plasma contained severalfold higher levels of progastrin than of amidated gastrins and that the removal of the CRC tumor resulted in a marked reduction in plasma progastrin level without a significant alteration in plasma levels of amidated gastrins. Both gastrin and CCKb-R mRNA were detected in the cancer tissue and resection margin by RT-PCR, and similary, COX-1 and COX-2 mRNA were expressed in these tissues of moast CRCs. The seroprevalence of Hp, especially that expressing CagA, and levels of IL-1á, but not other cytokines, were significantly higher in CRC patients than in 100 age-...

    5/32

    Tytuł oryginału: Case presentation of gastrinoma combined with gastric carcinoid with the longest survival record - Zollinger-Ellison syndrome: pathophysiology, diagnosis and therapy.
    Autorzy: Konturek Stanisław J., Konturek Piotr C., Bielański Władysław, Lorens Krzysztof, Sito Edward, Konturek Jan W., Kwiecień Sławomir, Bobrzyński Andrzej, Pawlik Teresa, Karcz Danuta, Areny Hany, Stachura Tomasz
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.CS43-CS59, il., bibliogr. 129 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Zollinger-Ellison syndrome is a very rare disease caused by tumor with gastrin producing cells accompanied by hypergastrinemia leading to gastirc hypersecretion and peptic ulcers and their complications. Female case of gastrinoma (Zollinger-Ellison syndrome; Z-E) with a record of 38 yrs of survival. Acute gastro-duodenal ulcers started at 28 yr of age and Z-E was diagnosed by using gastrin assays. Basal and maximal acid outputs and ratio of basal/maximal outputs were away over normal limits. Because of ulcer recurrence and complications, patients was subjected to several gastric surgeries but refused total gastrectomy. She was also treataed with many H2-receptor (R) antagonists and proton-pump inhibitors (PPI), each new drug being initially highlyt effective but then showing declinig efficacy except when PPI, lansoprazole was used. The gastrin level rose in the course of disease from initial high value of 2000 pg/mL to the extreme 4500 ng/mL at present. During the last 2 yrs, metastasis mainly to liver developed and they were successfully treated by synthetic octapeptided derivative of somatostatin and, as a result, metastatis partly reduced and plasma gastrin drasticly decreased. Biopsy taken from liver metastasis showed the presence of typical gastrinoma cells with gastrin and chromogranin, while that from oxyntic mucosa revealed the ECL-cell hyperplasia with corcinoid tumors and unexpected gastric atrophy. This phenomenal case described in this article might be the new proven evidence needed by gastroenterologists to overturn the traditional treatemnt using total gastrectomy as a treatment of choice to the partial gastrectomy combined with proton pump inhibitors.

    6/32

    Tytuł oryginału: Wireless capsule endoscopy - beyond the frontiers of flexible gastrointestinal endoscopy.
    Autorzy: Rabenstein Thomas, Krauss Norbert, Hahn Eckhart G., Konturek Peter
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.RA128-RA132, il., bibliogr. 32 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • psy

    Streszczenie angielskie: Wireless capsule endoscopy is currently the outstanding technical innovation in diagnostic gastrointestinal endoscopy. Especially for small bowel diseases this new technique offers several potential advantages compared to traditional diagnostic tools. Capsule endoscopy is a painless procedure that can be performed as an ambulatory endoscopic examination. First experimental studies proved the good tolerance of the capsule endoscopy ad the possibility of a complete visual investigation of the small bowel. Clinical studies demonstrated possible fields of application: Obscure chronic or intermittent gastrointestinal blood loss and inflammatory bowel disease. The major risk of the procedure - intestinal obstruction by the capsule - may hinder its use in the diagnosis of polyps or tumors in the small bowel. In the next years it will be exciting to see whether capsule endoscopy will finally reach the clinical significance we expect at the moment. Possibly, the diagnostic algorithm for obscure gastrointestinal bleeding has to be changed in the future due to the abandonment of less effective procedures.

    7/32

    Tytuł oryginału: Impact of Helicobacter pylori and nonsteroidal anti-inflammatory drugs on gastric ulcerogenesis in experimental animals and in humans.
    Autorzy: Pawlik Teresa, Konturek Peter C., Konturek Jan W., Konturek Stanisław J., Brzozowski Tomasz, Cześnikiewicz Marta, Płonka Małgorzata, Bielański Władysław, Areny Hany
    Źródło: Eur. J. Pharmacol. 2002: 449 (1/2) s.1-15, il., bibliogr. s. 13-15
    Sygnatura GBL: 312,088

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta

    Streszczenie angielskie: Helicobacter pylori (H. pylori) and nonsteroid anti-flammatory drugs (NSAID) are the most common pathogens in the gastroduodenal mucosa in animals and humans, but their relationship in ulcerogenesis has been little studied. Acording to some authors, H. pylori infections in humans does not act synergistically with NSAID on ulcer healing, therefore, there is no need to eradicate the germ. This notion is supported by the finding that the eradication of H. pylori does not affect NSAID-induced gastropatyhy treated with omeprazole and that H. pylori inferction induced a strong cyclooxygenase-2 expression resulting in excessive biosynthesis of gastroprotective prostaglandins, which should in turn counteract NSAID-induced gastropathy and heal existing ulcer. Other investigators claim that H. pylori infection acts synergistically with NSAID on ulcer development, therefore, H. pylori should be eradicated, particularly at the start of long-term NSAID therapy. Maastricht 2-2000 consensus also recommends eradication prior to NSAID treatment, but this eradication does not appear to accelerate ulcer healing or to prevent the recurrent ulcers in NSAID users. Our studies in almost 6000 dyspeptic patients undergoing upper endoscopy and [13C]-urea breath test (UBT) revealed that about 70 p.c. of these patients are H. pylori (+) and about 30.6 p.c. of these develop gastroduodenal ulcers. Of these ulcers, over 70 p.c. were H. pylori (+) positive, 12 p.c. NSAID (+), 8 p.c. both H. pylori (+) and NSAID (+), while 22 p.c. ulcers were H. pylori (-) and NSAID (-) or "idiopathic" ulcers...

    8/32

    Tytuł oryginału: mRNA expression of EGF receptor ligands in atrophic gastritis before and after Helicobacter pylori eradication.
    Autorzy: Schiemann Uwe, Konturek Jan W., Assert Roland, Rembiasz Kazimierz, Konturek Stanisław J., Pfeiffer Andreas
    Źródło: Med. Sci. Monitor 2002: 8 (2) s.CR53-CR58, il., tab., bibliogr. 34 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • genetyka
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Epidermal growth factor (EGF) receptor ligands (EGFRL) including transforming growth factor alpha (TGF-ŕ), amphiregulin, and heparin binding -EGF (HB-EGF) are involved in gastric mucosal repair in chronic gastritis. Their mRNA expression has been shown to be upregulated after Helicobacter pylori (H. p.)-eradication but little is known about this gene expression in atrophic gastritis. The purpose of our study was to investigate EGFRL mRNA expression in gastric mucosa of patients with atrophic gastritis before and after H. p.-eradication. Material/Methods: Antral mucosal biopsies were obtained during endoscopy in 10 H. p. positive patients with atrophic gastritis and in 10 H. p. negative controls with intact mucosa. Total RNA of antral biopsies was extracted and RT-PCR was performed, the PCR-products being measured densitometrically. Values were compared with mRNA expressions in H. p. negative antral mucosa (n = 10). Results: Gastric biopsies revealed mRNA expression for TGF-ŕ, amphiregulin and HB-EGF, both in H. p. positive atrophic antritis and in H. p. negative healthy mucosa. The mRNA expression of TGF-ŕ in atrophic gastritis was significantly upregulated after H. p.-eradication, whereas that of amphiregulin did not change after this eradication. Expression of HB-EGF mRNA was higher in H.p.-infection than after H.p.-eradication or in H.p. negative healthy subjects. Conclusions: H.p. positive atrophic gastritis is associated with differential mRNA expression of EGF receptor ligands. H.p.-eradication in this entity leads to unequal changes of these growth factor expressions compared to chronic active gastritis without atrophy.

    9/32

    Tytuł oryginału: Zakażenie Helicobacter pylori, niesteroidowe leki przeciwzapalne i palenie a ryzyko wrzodów żołądkowo-dwunastniczych. Czy infekcja Helicobacter pylori wzmaga, czy zapobiega wrzodom trawiennym, wywołanym przez niesteroidowe leki przeciwzapalne?
    Autorzy: Konturek Stanisław J.
    Źródło: Przew. Lek. 2002 (6) s.60, 62, 64-76, il.
    Sygnatura GBL: 313,495

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca przeglądowa

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Zakazenie Helicobacter pylori (Hp), podobnie jak zażywanie niesteroidowych leków przeciwzapalnych (NLPZ), uważa się za główne, obok palenia papierosów, czynniki prowadzące do zapalenia żołądka i rozwoju uszkodzeń błony śluzowej i wrzodów trawiennych. Istnieje jednak spór, czy jednoczesne działanie Hp i NLPZ na żołądek skutkuje zwiększonym ryzykiem rozwoju wrzodu i czy zatem należy ludzi zainfekowanych Hp i jednocześnie zażywających NLPZ, poddawać eradykacji Hp, czy też odwrotnie - infekcja Hp działa korzystnie na wrzody wywołane NLPZ i eradykacja Hp mija się z celem.

    10/32

    Tytuł oryginału: Antygeny powierzchniowe w diagnostyce choroby Gravesa-Basedowa.
    Tytuł angielski: Surface antigen in the epithelial and stroma cells in Graves' disease.
    Autorzy: Konturek Aleksander, Barczyński Marcin, Cichoń Stanisław
    Źródło: Pol. Prz. Chir. 2002: 74 (12) s.1180-1193, il., tab., bibliogr. 30 poz. - Tekst równol. w jęz. ang.
    Sygnatura GBL: 313,570

    Hasła klasyfikacyjne GBL:
  • immunologia
  • endokrynologia

    Typ dokumentu:
  • praca kliniczna
  • praca związana ze zjazdem

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie polskie: Celem pracy było omówienie najnowszego stanu wiedzy na temat roli czynników immunologicznych (determinant antygenowych) w powstawaniu nadczynności tarczycy w przebiegu choroby Gravesa-Basedowa. Materiał i metodyka. Badaniem na obecność antygenów zostało objętych 69 chorych. Grupę badaną stanowiło 36 chorych, grupę kontrolną 33 chorych z wolem guzowatym obojętnym. W grupie badanej było 28 (77,8 proc.) kobiet i 8 (22 proc.) mężczyzn, a w grupie kontrolnej 31 (93,9 proc.) kobiet i tylko 2 (6,1 proc.) mężczyzn. W grupie pacjentów z chorobą Gravesa-Basedowa średnia wieku wynosiła 41,5 ń 12,5 w przedziale od 17 do 71 lat. W pracy wykorzystano metody diagnostyki immunochistochem. z zastosowaniem przeciwciał monoklonalnych. W badanych grupach kolejne wyniki pomiarowe opisano poprzez średnią arytmetyczną, odchylenie standardowe (s). Ocenę różnic pomiędzy badanymi grupami dokonano przez zastosowanie testu Manna-Witney'a U oraz testu chi2 i dokładnego testu Fishera. Wyniki. W przebiegu choroby Gravesa-Basedowa tyreocyty i komórki podścieliska wykazują ekspresje determinanty HLA-DR na swojej powierzchni w sąsiedztwie nacieków limfocytowych. Determinanty CD28 i CD40 współwystępują z determinantą HLA-DR na tyerocytach i komórkach podścieliska. Powyższe badania sugerują, że zmienione komórki pęcherzykowe tarczycy uczestniczą w aktywacji limfocytów T. Wnioski. Ekspresja determinant HLA-DR oraz molekuł adhezyjnych CD28 i CD40, obejmująca komórki pęcherzykowe tarczycy oraz komórki podścieliska, stanowi istotny czynnik ...

    11/32

    Tytuł oryginału: Ekspresja cytokin i rola reaktywnych form tlenu w uszkodzeniu wywołanym ischemią-reperfuzją w śluzówce żołądka szczura : praca doktorska
    Autorzy: Duda-Chodak Aleksandra, Konturek Stanisław J. (promot.).; Uniwersytet Jagielloński Collegium Medicum, Wydział Lekarski, Katedra Fizjologii w Krakowie
    Źródło: 2002, [2], 97 k. : il., tab., bibliogr. 166 poz., streszcz., maszyn.
    Sygnatura GBL: 45/19756

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • praca doktorska

    Wskaźnik treści:
  • zwierzęta
  • szczury

    12/32

    Tytuł oryginału: Incidence of complications of peptic ulcers in patients with Helicobacter pylori (Hp) infection and/or NSAID use in the era of Hp eradication.
    Autorzy: Bobrzyński Andrzej, Bęben Piotr, Budzyński Andrzej, Bielański Władysław, Płonka Małgorzata, Konturek Stanisław J.
    Źródło: Med. Sci. Monitor 2002: 8 (8) s.CR554-CR557, il., bibliogr. 16 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Hp and NSAID are considered as major pathogens in peptic ulcerations and their complications but little is konwn about the incidence of ulcaers and their complications following widespread use of Hp eradication. The aim of the study were: 1) to analyze incidence of ulcers and their complications, bleeding and perforations at time when the HP eradicaton has been used in ulcer therapy, and 2) to assess the impact of Hp infection and NSAID use on the incidence of ulcers and complications. Material/Methods: From 1996 to 2001, 381 patients with complications of peptic ulcers were admitted to the emergency surgery, including 273 patients with bleeding ulcers and 108 with perforations out of a sample of 6515 dyspeptic patients examined with upper endoscopy and 13C-urea breath test (UBT). Results: The rate of ulcer bleeding and perforations, remained relatively constant throughout the study period. NSAID use in that group increased form 15.8 p.c. in 1999 to 19.3 p.c. in 2001. The incidence of HP in patients with complications assessd by UBT or CLO was 76.7 p.c., while the incidence of Hp in 7920 patients ranged form 72.8 p.c. in 1996 to 53.8 p.c. in 2001. There were 1940 (29.7 p.c.) patients with duodenal and/or gastric ulcer diagnosed by upper gastroscopy. The decline in the prevalence of peptic ulcer from about 44 p.c. to 8 p.c. occurred over the same time. A slight increase in the number of ulcer resulting from NSAID use was observed so was the number of ulcers without Hp or NSAID (idiopathic). Conclusions: Despite decreased Hp prevalence, the incidence of ulcers complications remained unchanged probably due to increased use of NSAID and the appearance of idiopathic ulcers.

    13/32

    Tytuł oryginału: Oznaczanie antygenów Helicobacter pylori w kale z zastosowaniem testu Premier Platinum HpSA.
    Tytuł angielski: The detection of Helicobacter pylori antigens in stool with Premier Platinum HpSA test.
    Autorzy: Wiśniewska Monika, Bąk-Romaniszyn Leokadia, Płaneta-Małecka Izabela, Rechciński Tomasz, Płonka Małgorzata, Bielański Władysław, Konturek Stanisław J., Rudnicka Wiesława, Chmiela Magdalena
    Źródło: Pediatr. Współcz. 2002: 4 (3) s.373-376, tab., bibliogr. 5 poz., sum. - 2 Kongres Polskiego Towarzystwa Gastroenterologii, Hepatologii i Żywienia Dzieci Bydgoszcz 06. 2002
    Sygnatura GBL: 313,561

    Hasła klasyfikacyjne GBL:
  • pediatria
  • gastroenterologia
  • immunologia
  • mikrobiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie polskie: Wprowadzenie: Podczas przebiegu zakażeń wywoływanych przez zlokalizowane w nabłonku żołądka pałęczki H. pylori może dochodzić do znaczne koncentracji antygenów tego drobnoustroju w kale. Taka hipoteza opiera się na przypuszczeniu o fekalno-oralnym modelu transmisji zakażenia. Sugeruje się, iż obecność antygenów H. pylori w kale może być wskaźnikiem aktualnego zakażenia tymi bakteriami natomiast ich zanik może świadczyć o skutecznej eradykacji drobnoustrojów. Cel pracy: Celem przeprowadzonych badań było porównanie skuteczności testu PP HpSA ze sktuecznością metod inwazyjnych: RUT, HLO lub nieinwazyjengo testu UBT i badania serologicznego (ELISA, IgG anty-EG), w diagnozowaniu zakażeń wywołwyanych przez H. pylori. Materiałi meotdy: W obecnie przeprowadzonych badaniach do wykrywania zakażeń wywoływanych przez H. pylori zastosowano nieinwazyjny, immunoenzymatyczny test Premier Platinum HpSA-PP HpSA (Meridian Diagnostics, Cincinnati, Ohio USA), przeznaczony do wykrywania antygenów tego drobnoustroju w kale. Test ten opiera się na aktywności poliklonalnych przeciwciał rozpoznających antygeny H. pylori. Wyniki testu PP HpSA odnoszono do wyników testów inwazyjnych: szybkiego testu ureazowego - RUT oraz badania histopatologicznego - HLO lub nieinwazyjengo testu oddechowego z użyciem mocznika znakowanego węglem 13C-UBT i badania serologicznego (ELISA), mającego na celu określenie występowania w surowicach osób badanych przeciwciał klasy IgG przeciwko antygenom ekstraktu glicynowego (EG) wzorcowego szczepu H. pylori CCUG 17874...

    14/32

    Tytuł oryginału: Cat-scratch disease in an immunocompromised host.
    Autorzy: Harsch Igor Alexander, Schahin Simin Pour, Schmelzer Alexander, Hahn Eckhart Georg, Konturek Peter Christopher
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CS26-CS29, il., bibliogr. 20 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • immunologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: Themain causative agents of cat-scratch disease are Bartonella henselae, tiny, gram-negative bacilli. The disease usually has a benign course with the development of a papule at the inoculation site, followed by regional lymphadenopathy. In most cases, complete resolution occurs, but in immunocompromised hosts, the course of the disease can be aggravated. Case report: A patietn recieved methotrexate and corticosteroids for 3 months due to rheumatoid arthritis. He developed fever, exanthema and leukopenia under methotrexate therapy. Dark red indurations with central ulcerations at his right thigh revealed a further problem apart from the methotrexate-induced leucopenia and immunosuppression. The ulcerations were the remainders of recurrent scratches from the patient's cat. The patient's antibody titers against Bartonella henselae remained low and inguinal lymph node swelling was only for a short time to be observed, this reaction obviously weakened as a result of the immunosuppression. However, the typical course, the exclusion of other reasons for the exanthema and the rapid improvement of the patient's condition after antibiotic treatment ascertained the diagnosis. Conclusions: In immunocompromised hosts, diseases with a typically benign course can become severe and life-threatening illnesses. Ownership of pets should be taken into consideration before onset of an immunosuppressive therapy.

    15/32

    Tytuł oryginału: Effects of Helicobacter pylori and nonsteroidal anti-inflammatory drugs on gastric mucosa and risk of gastro-duodenal ulcerations in men.
    Autorzy: Bielański Władysław, Konturek Stanisław J., Płonka Małgorzata, Cześnikiewicz Marta, Penar Agnieszka, Jędrychowski Wiesław
    Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.139-162, il., bibliogr. 59 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
    Sygnatura GBL: 301,250

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Helicobacter pylori (Hp) and nonsteroidal anti-inflammatory drugs (NSAID) are the most common pathogens in the stomach, but their interaction on gastro-duodenal mucosa has been little studied. Hp infection in humans does not interfere with NSAID-induced gastric ulcer healing by omeprazole, therefore, there is no rationale to eradicate the germ under these conditions. Hp infection induces COX-2 expression resulting in excessive biosynthesis of gastroprotective prostaglandin (PG), which should in turn counteract NSAID-induced gastropathy and contribute to healing of existing ulcers. Some investigators claim that Hp infection acts synergistically with NSAID on ulcergenesis and propose that Hp should be eradicated, particularly at the onset of long-term NSAID therapy but this is the subject of controversy. Material and methods: Our studies on 6515 dyspeptic patients undergoing upper endoscopy and 13C-urea breath test (UBT) revealed that about 70 p.c. of these patients are Hp positive and 31 p.c. of them develop gastro-duodenal ulcers. Of these ulcers, 66 p.c. were Hp positive non NSAID users, 3 p.c. were Hp negative and NSAID users, 8 p.c. were both Hp positive and NSAID users, while 23 p.c. ulcers were both Hp and NSAID negative. An evidence was obtained for negative interaction between Hp infection and NSADI on risk of gastro-duodenal ulcers suggesting that Hp may attenuate the peptic ulcerogenesis. Conclusions: Our results support the concept that 1) the interaction between Hp infection ...

    16/32

    Tytuł oryginału: Częstość występowania infekcji Helicobacter pylori u pacjentów z dolegliwościami górnego odcinka przewodu pokarmowego na terenie Krakowa i okolic : praca doktorska
    Autorzy: Płonka Małgorzata, Konturek Stanisław J. (promot.).; Uniwersytet Jagielloński Collegium Medicum, Wydział Lekarski, Zakład Fizjologii Klinicznej w Krakowie
    Źródło: 2002, 118 k. : il., tab., bibliogr. 191 poz., streszcz., maszyn.
    Sygnatura GBL: 45/20329

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca epidemiologiczna
  • praca doktorska

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    17/32

    Tytuł oryginału: Gastroenterologia w praktyce
    Autorzy: Bartuzi Zbigniew, Długosz Jan W., Gabryelewicz Antoni, Gonciarz Zbigniew, Jurkowska Grażyna, Konturek Stanisław J., Kwiecień Sławomir, Ładny Jerzy Robert, Łaszewicz Wiktor, Marlicz Krzysztof, Mazur Włodzimierz, Prokopowicz Danuta, Puchalski Zbigniew, Stasiewicz Jan, Wereszczyńska-Siemiątkowska Urszula, Zaremba-Woroniecka Anna
    Opracowanie edytorskie: Gabryelewicz Antoni (red.).
    Źródło: - Warszawa, Wydaw. Lekarskie PZWL 2002, 368, [1] s., [4] s. tabl. : il., tab., bibliogr. [przy rozdz.], 21 cm.
    Seria: Biblioteka Lekarza Praktyka 18
    Sygnatura GBL: 735,974

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Wskaźnik treści:
  • ludzie

    18/32

    Tytuł oryginału: The influence of cholecystokinin on gastric myoelectrical activity in duodenal ulcer following Helicobacter pylori eradication - an electrogastrographic study.
    Autorzy: Budzyński A., Bobrzyński A., Lorens K., Konturek P. C., Thor P., Konturek S[anisław] J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (2) s.171-182, il., bibliogr. 34 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Cholecystokinin (CCK) plays an important role in the regulation of postprandial gastric motor activity which was found to be abnormal in duodenal ulcer patients. This study was designed to compare the influence of CCK on gastric myoelectrical function in duodenal ulcer patients and healthy controls. Fifteen patients with activite duodenal ulcer and Helicobacter pylori (H. pylori) infection and 15 healthy controls were included into this study. Electrogastrography w(EGG) was performed before and 4 weeks after the eradication of H. pylori in ulcer patients and in healthy controls. We compared EGG parameters in the fasting and postprandial period and during intravenous infusion of caerulein, and analog of CCK with or without of loxiglumide, a specific CCK-1 receptor antagonist. The amplitude of fasting EGG in duodenal ulcer patients was similar to that in control subjects and was not affected by H. Pylori eradication. In contract, the amplitude of postprandial EGG was markedly increased in duodenal ulcer patients when compared to that in healthy controls and it was significantly reduced following the eradication of H. pylori. The blockade of CCK-1 receptors with loxiglumide in healthy controls or H. pylori eradicated ulcer patients significantly enhanced postprandial EGG amplitude almost to the level observed in the infected duodenal ulcer, patients, but failed to affect this amplitude in ulcer patients. Exogenous caerulein, an analog of CCK, failed to affect EGG amplitude in duodenal ulcer patients with H. pylori ...

    19/32

    Tytuł oryginału: The influence of epidermal growth factor on the course of ischemia-reperfusion induced pancreatitis in rats.
    Autorzy: Tomaszewska R., Dembiński A[rtur], Warzecha Z., Ceranowicz P., Konturek S[tanisław] J., Stachura J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (2) s.183-198, il., tab., bibliogr. 49 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Acute pancreatitis is accompanied by the enhanced expression of EGF in the pancreas and the administration of EGF was found to exhibit the beneficial efect on edematous cerulein-induced pancreatitis. Therefore, we decided to determine the influence of EGF on necro-hemorrhagic pancreatitis induced by ischaemia and reperfusion (I/R). Acute pancreatitis ws induced in rats by rectricting the pancreatic blood flow (PBF) in the inferior splenic artery for 30 min using microvascular clips. EGF was administered three times daily (10ć/kg per dose s.c.) starting immediately after the clips removal. Rats were sacrificied on day 1,3,5,10 and 21 following ischemia. PBF was measured using a laser Doppler flowmeter. Morphological signs of pancreatitis, as well as the levels of plasma amylase, lipase, interleukin-1á and interleukin-10 concentration and pancreatic cell proliferation were examined. Results: Ischemia with reperfusion caused necro-hemorrhagic pancreatitis with a histological and biochemical maifestation of pancreatic damage, followed by a spontaneous regeneration. The administration of EGF caused the reduction in the histological signs of pancreatic damage, such as necrosis, edema and leukocyte infiltration, and accelerated the pancreatic repair. Also, EGF treatment significantly attenuated the reduction in pancreatic blood flow and DNA syntehsis. The activity of plasma amylase and lipase, as well as plasma interleukin-1á and interleukin-10 concentrations were decreased in EGF treated animals. Conclusions: ...

    20/32

    Tytuł oryginału: Rola histaminy podanej obwodowo i centralnie w gastroprotekcji i wydzielaniu żołądkowym : praca doktorska
    Autorzy: Pawlik Michał W., Konturek Stanisłąw J. (promot.).; Uniwersytet Jagielloński Collegium Medicum, Katedra Fizjologii, Zakład Fizjologii Klinicznej w Krakowie
    Źródło: 2002, 116 k. : il., tab., bibliogr. 144 poz., streszcz.
    Sygnatura GBL: 45/20438

    Hasła klasyfikacyjne GBL:
  • farmacja
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • praca doktorska

    Wskaźnik treści:
  • zwierzęta
  • szczury

    21/32

    Tytuł oryginału: Influence of chronic Helicobacter pylori infection on ischemic cerebral stroke risk factors.
    Autorzy: Majka Jolanta, Róg Teresa, Konturek Peter C., Konturek Stanisław J., Bielański Władysław, Kowalsky Marek, Szczudlik Andrzej
    Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR675-CR684, il., tab., bibliogr. 100 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: Infection by Helicobacter pylori (Hp) has been linked to extradigestive pathologies including ischemic cerebral disease. The aim of our study was to assess the relationship between chronic Hp infection and ischemic stroke risk factors. Material/Methods: 80 patients (pts) aged 60 - 75 years with ischemic stroke confirmed by CT scans (group I) and 80 age- and gender-matched healthy controls (group II) were included into trial. Atherosclerotic plaques from 20 Hp positive pts were obtained at carotid endarterectomy for Hp DNA assessment by PCR. In all groups following parameters were determiend; 1) the prevalence of Hp infection using 13C-Urea Breath Test (UBT), 2) plasma anti-Hp and anti-CagA IgG and interleukin-8 (IL-8), and 3) palsma lipids and fibrinogen. Hp positive pts and controls received one-week anti-Hp therapy and after six months total cholesterol, low-density lipoprotein (LDL)-cholesterol, fibrinogen and IL-8 levels were re-examined. Results: Hp infection was detected by UBT in 83.75 p.c. of stroke pts but only in 65 p.c. of controls. DagA seropositivity was also significantly higher in stroke pts (57.5 p.c.) than in controls (33.75 p.c.). Plasma levels of cholesterol, LDL-cholesterol and fibrinogen as well as IL-8 were significantly higher in Hp positive subjects, especially in pats with ischemic stroke. Six months following successful anti-Hp therapy, the plasma levels of total cholesterol, LDL-cholesterol, fibrinogen and IL-8 were significantly lower than those in Hp positive stroke pts and contorls. Conclusions: Hp infection represents risk factor of ischemic stroke via an interaction of Hp cytotoxings of cytokines with atherosclerotic plaques in carotic arteries.

    22/32

    Tytuł oryginału: Historia Oddziału i III Katedry Chirurgii Ogólnej Szpitala im. Gabriela Narutowicza [w Krakowie]
    Autorzy: Jamski Jerzy, Konturek Aleksander
    Źródło: W: Pamiętnik 60. Jubileuszowego Zjazdu Towarzystwa Chirurgów Polskich. T. 2 - Warszawa, 2002 s.61-63, bibliogr. 11 poz. - 60 Jubileuszowy Zjazd Towarzystwa Chirurgów Polskich Warszawa 12-15.09. 2001
    Sygnatura GBL: 735,679

    Hasła klasyfikacyjne GBL:
  • chirurgia

    Typ dokumentu:
  • praca historyczna
  • praca związana ze zjazdem

    Wskaźnik treści:
  • historia XX wieku

    23/32

    Tytuł oryginału: Częstość występowania szczepów Helicobacter pylori kodowanych genem CagA u chorych z krwawiącym wrzodem żołądka
    Autorzy: Rembiasz Kazimierz, Bobrzyński Andrzej, Winiarski Marek, Konturek Stanisław, Karczewska Elżbieta, Budzyński Andrzej
    Źródło: W: Pamiętnik 60. Jubileuszowego Zjazdu Towarzystwa Chirurgów Polskich. T. 2 - Warszawa, 2002 s.164-166, bibliogr. 12 poz., sum. - 60 Jubileuszowy Zjazd Towarzystwa Chirurgów Polskich Warszawa 12-15.09. 2001
    Sygnatura GBL: 735,679

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • gastroenterologia
  • genetyka

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska
  • dorośli 45-64 r.ż.

    24/32

    Tytuł oryginału: Znaczenie aldehydowych produktów peroksydacji lipidów w doświadczalnych uszkodzeniach błony śluzowej żołądka indukowanych przez aspirynę, stres i ischemię z następową reperfuzją.
    Tytuł angielski: Importance of aldehyde products of lipid peroxidation in the formation of gastric lesions induced by aspirin, ischemia - reperfusion and stress.
    Autorzy: Kwiecień Sławomir, Brzozowski Tomasz, Konturek Stanisław J.
    Źródło: Gastroenterol. Pol. 2002: 9 (4) s.273-280, il., bibliogr. 41 poz., sum.
    Sygnatura GBL: 313,180

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie polskie: Wprowadzenie: Niesterydowe leki przeciwzapalne (n.l.pz.), a szczególnie aspiryna, są powszechnie używane w terapii różnych schorzeń. Powszechnie znane są także efekty uboczne ich działania, zlokalizowane przede wszystkim w obrębie żołądka, takie jak krwotoczne zapalenie błony śluzowej żołądka, powstawanie erozji i nadżerek błony śluzowej, a nawet perforacja ściany żołądka. Ze względu na ryzyko poważnych konsekwencji klinicznych objawów ubocznych i stosowania n.l.pz. istotna jest znajomość mechanizmów patogenezy uszkodzeń błony śluzowej żołądka w wyniku tych środków. Cel pracy: Celem naszych badań było ustalenie znaczenia wolnych rodników tlenowych w powstawaniu ostrych uszkodzeń śluzówki żołądka wywołanych przez aspirynę (ASA), ischemię i reperfuzję (I/R) oraz narażenie zwierząt na stres z oziębienia i unieruchomienia (WRS). Materiał i metody: Eksperymenty zostały przeprowadzone na szczurach rasy Wistar. Do oceny żołądkowego przepływu krwi psłużono się przepływomierzem laserowym Dopplera. Powierzchnię uszkodzeń błony śluzowej żołądka mierzono metodą planimetryczną. Poziom malonylosialdehydu (MDA) i 4-hydroksynonenalu (4-HNE) w śluzówce żołądka zmierzono metodą kolorymetryczną. Wyniki: Wykazaliśmy, że dożołądkowe podanie aspiryny w dawce 150 mg/kg powoduje pojawienie się ostrych uszkodzeń błony śluzowej żołądka wraz ze znamiennym obniżeniem żołądkowego przepływu krwi. Zmianom tym towarzyszy wzrost poziomu MDA i 4-HNE. Po zastosowniu zmiatatczy wolnych rodników ...

    Streszczenie angielskie: Introduction: Nonsteroidal anti-inflammatory drugs (NSAID), especially aspirin, are commonly used in the therpay of various diseases. The side effects of these drugs, predominantly localized in a stomach, such as bleedings, acute lesions and even perforations, are widely known. The elucidation of gastric damage mechanism is crucial in order to explain severe clinical complications after NSAID administration. Objectives: Therefore, the aim of our present study was to determine the role of reactive oxygen species action in the mechanism of gastric mucosal damage induced by aspirin and to compare these effects with those in other models of gastric injury induced by ischemia/reperfusion (I/R) and stress. Material and methods: Experiments were carried out on Wistar rats. To assess gastric blood flow laser Doppler flowmeter was used. The area of gastric lesions was determined by planimetry. The colorimetric assay was used to determine gastric level of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE). We demonstrated that intragastric administration of 150 mg/kg aspirin or exposures of animals to I/R or water immersion and restraint stress (WRS) resulted in appearance of acute gastric mucosal lesions accompanied by significant decrease of gastric blood flow. These lesions were also accompanied by increase of MDA and 4-HNE level. Pretreatment with scavengers (allopurinol, SOD) or substances which improve gastric microcirculation (nitroglycerin, pentoxiffiline) before the ...

    25/32

    Tytuł oryginału: Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury.
    Autorzy: Kwiecień S., Brzozowski T., Konturek S[tanisław] J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (1) s.39-50, il., bibliogr. 33 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Bacground: The exposure of gastric mucosa to damaging factors, such as ethanol, water restraint stress, or ischemia followed by reperfusion, procedures pathological changes; inflammatory process, hemorrhagic erosins, even acute ulcers. The base of these changes is a disturbance of protective mechanisms and disrupture of gastric mucosal barrier. Previous studies pointed out the role of disturbances of gastric blood flow, mucus secretion and involvement of prostaglandins and nitric oxide formation in the pathomechanism of gastric mucosa lesions. The role of reactive oxygen species (ROS) in these processes has been little studied. Aim: The purpose of our present investigations is to explain the participation of ROS in acute gastric mucosal damage by various irritants. Material and methods: Experiments were carrying out on 80 male Wistar rats. To assess gastric blood flow (GBF) laser Doppler flowmeter was used. The area of gastric lesions was established by planimetry. The levels of proinflammatory cytokines were measured by ELISA technique. The colorimetric assays were used to determine of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) as well as superoxide dismutase (SOD) activity. Results: We demonstrated that 3.5 h of water immersion and restraint stress (WRS), 30 min of gastric ischemia followed by 60 min of reperfusion or intragastric administration of 100 p.c. ethanol, all resulted in appearance of acute gastric mucosal lesions accompanied by a significant decrease of gastric blood flow. These lesions are also accompanied by the significant increase...

    26/32

    Tytuł oryginału: Sensory nerves in central and peripheral control of pancreatic integrity by leptin and melatonin.
    Autorzy: Jaworek J[olanta], Bonior J., Leja-Szpak A. K., Kot M., Tomaszewska R., Stachura J., Pawlik W. W., Konturek S[tanisław] J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (1) s.51-74, il., tab., bibliogr. 45 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Central nervous system affects pancreatic secretion of enzymes however, the neural modulation of acute pancreatitis has not been investigated. Leptin and melatonin have been recently reported to affect the inflammatory response of various tissues. The identification of specific receptors for both peptides in the pancreas suggests that leptin and melatonin could contribute to the pancreatic protection against inflammation. The aim of this study was: 1) to compare the effect of intracerebroventricular (i.c.v.) or intraperitoneal (i.p.) administration of leptin or melatonin on the course of caerulein-induced pancreatitis (CIP) in the rat, 2) to examine the involvement of sensory nerves (SN) and calcitonin gene-related peptide (CGRP) in pancreatic protection afforded by leptin or melatonin, 3) to assess the effect of tested peptides on lipid peroxidation products (MDA + 4-HNE) in pancreas of CIP rats, 4) to investigate the influence of leptin or melatonin on nitric oxide (NO) release from isolated pancreatic acini and 5) to determine the effects of caerulein and leptin on leptin receptor gene expression in these acini by RT-PCR was induced by subcutaneous (s.c.) infusion of caerulein (25 ćg/kg) to the conscious rats, confirmed by the significant increases of pancreatic weight and plasma amylase and by histological examination. This was accompanied in marked reduction of pancreatic blood flow and significant rise of MDA + 4HNE in the pacreas. Leptin or melatonin were administered i.p. or i.c.v. 30 min prior to the start of CIP...

    27/32

    Tytuł oryginału: Interaction of Helicobacter pylori (Hp) and nonsteroidal anti-inflammatory drugs (NSAID) on gastric mucosa and risk of ulcerations.
    Autorzy: Konturek Peter C., Konturek Stanisław J., Cześnikiewicz Marta, Płonka Małgorzata, Bielański Władysław
    Źródło: Med. Sci. Monitor 2002: 8 (9) s.RA197-RA209, il., bibliogr. 57 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • gastroenterologia
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: Hp and NSAID are the most common pathogens in the stomach, but their interaction on gastro-duodenal mucosa has been little studies. Hp infection in humans does not interfere with NSAID-induced gastric ulcer healing by omeprazole, therefore, there is no rationale to eradicate the germ. Hp infection induces COX-2 expression resulting in excessive biosynthesis of gastroprotective prostaglandin (PG), which should in turn counteract NSAID-induced gastropathy and contribute to healing of existing ulcers. Some investigators claim that Hp infection acts synergistically with NSAID on ulcerogenesis and propose that Hp should be eradicated, particularly at the onset of long-term NSAID therapy. Our studies in about 6500 dyspeptic patients undergoing upper endoscopy and 13C-urea breath test revealed that about 70 p.c. of these patients are Hp positivie and 31 p.c. of these develop gastro-duodenal ulcers. Of these ulcers, 66 p.c. were Hp positive and NSAID negative, 3 p.c. - NSAID positive and Hp negative, 8 p.c. were both Hp positive and NSAID positive, while 23 p.c. ulcers were Hp and NSAID negative. An evidence was obtained for negative interaction between Hp infectio and NSAID on risk of gastro-duodenal ulcers suggesting that Hp may attenuate the peptic ulcerogenesis. Our results support the concept 1) the interaction between Hp infection and NSAID on gastro-duodenal ulcerations is antagonistic, 2) the Hp and NSAID are independent risk factors for peptic ulcerations in humans, 3) there is no need for the Hp eradication in NSAID-treated patients, and 4) the rate of ulcer complications (hemorrhage and perforation) remains constant despite the decrease in Hp and ulcer prevalence.

    28/32

    Tytuł oryginału: Effect of different muscle shortening velocities during prolonged incremental cycling exercise on the plasma growth hormone, insulin, glucose, glucagon, cortisol, leptin and lactate concentrations.
    Autorzy: Żołądź J. A., Duda K., Konturek S[tanisław] J., Śliwowski Z., Pawlik T., Majerczak J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.409-422, il., bibliogr. 33 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Background: Strenuous exercise was reported to involve the alteration in the release of some "stress" hormones such as growth hormone (GH), cortisol, catecholamines and appropriate adjustment of energy metabolism but the relative contribution of these hormones to metabolic response, to cycling exercise performed at different muscle shortening velocities, has not been clarified. Aims: The purpose of this experimet was to assess the effect of applying different pedalling rates during a prolonged incremental cycling exercise test on the changes in the plasma levels of growth hormone, cortisol, insulin, glucagon and leptin in humans. Material and methods: Fifteen healthy non-smoking men (means ń SD: age 22.9 ń 2.4 years; body mass 71.9 ń 8.2 kg; height 178 ń 6 cm; with VO2max of 3.896 ń 0.544 1 min**-1), assessed in laboratory tests, were subjects in this study. The subjects performed in two different days a prolonged incremental exercise tests at two different pedalling rates, one of them at 60 and another at 120 rev min**-1. During this tests the power output has increased by 30 W every 6 minutes. The tests were stopped when the subject reached about 70 p.c. ogf the VO2max. Results and conclusions: We have found that choosing slow or fast pedaliing rates (60 or 120 rey min **1), while generating the same external mechanical power output, had no effect on the pattern of changes in plasma cortisol, insulin, glucagon glucose and leptin concentrations. But, generation of the same external mechanical power output at ...

    29/32

    Tytuł oryginału: The role of reactive oxygen species in action of nitric oxide-donors on stress-induced gastric mucosal lesions.
    Autorzy: Kwiecień S., Brzozowski T., Konturek P. Ch., Konturek S[tanisław] J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 2) s.761-773, il., bibliogr. 42 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The experimental model of acute gastritis such as water immerision restraint (WRS) stress-induced gastric injury is useful tool in examination of pathomechanism of acute gastritis. Nitric oxide (NO) plays an important role in the maintenance of gastric barrier, however, the interaction between reactive oxygen species (ROS) and NO on gastric mucosal integrity has been little studied. The purpose of our present study was to explain the participation of ROS in healing of WRS-induced gastric lesions accelerated by NO. Experiments were carrying out on 120 male Wistar rats. To assess gastric blood flow (GBF) laser Doppler flowmeter was used and the number of gastric lesions was counted in each stomach. The colometric assays were used to determine gastric tissue level of malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), the products of lipid peroxidation by ROS, as well as superoxide dismutase (SOD) activity, the enzyme scavanger of ROS. We demonstrated that 3.5 h of WRS resulted in appearance of acute gastric lesions accompanied by a significant decrease of GBF. Biological effects of ROS were estimated by measuring tissue levels of MDA and 4-HNE, as well as the SOD activity. It was demonstrated that 3.5 h of WRS led to significant increase of mucosal levels of MDA and 4-HNE, and it was accompanied by a decrease of SOD activity. Pretreatment with NO-donors (SIN-1, SNAP, nitroglycerin, NO-ASA) resulted in reduction in gastric lesion number, increment of GBF, decrease of MDA and 4-HNE tissue level and increase of SOD activity. Suppression of ROS plays an important role in the...

    30/32

    Tytuł oryginału: Influence of leptin administration on the course of acute ischemic pancreatitis.
    Autorzy: Warzecha Z., Dembiński A[rtur], Ceranowicz P., Jaworek J., Konturek P. C., Dembiński M., Bilski J., Konturek S[tanisław] J.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 2) s.775-790, il., tab., bibliogr. 57 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • farmacja
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Leptin is involved in the regulation of food intake and previous studied have shown that leptin affects the inflammatory response in various tissues. The objective of this study was to examine the influence of leptin administration on the development and the course of acute ischemic pancreatitis. Acute pancreatitis was induced by limitation of pancreatic blood flow by clamping of inferior splenic artery for 30 min, followed by reperfusion. Leptin was administered three times daily at the dose 10 or 50 ćg/kg. Animals were sacrificed 1, 3, 5, 10 and 21 days after removal of vascular clips. Administration of leptin reduced development of pancreatic damage and accelerated pancreatic regeneration what was manifested by the improvement of pancreatic histology, the decrease in serum lipase and amylase activity, and the reduction in serum interleukin-1á concentration. Also, treatment with leptin caused the increase in the pancreatic blood flow and pancreatic DNA synthesis. Leptin administration was without effect on serum interleukin-10 concentration. Leptin at the dose 50 ć/kg was more effective than 10 ćg/kg. We conclude that leptin reduces the pancreatic damage in the course of ischemic pancreatitis and accelerates the pancreatic tissue repair. The beneficial effects of leptin appear to be dependent on the improvement of pancreatic blood flow, the increase in pancreatic cell growth, and the limitation of pro-inflammatory interleukin-1á release.

    31/32

    Tytuł oryginału: Role of endogenous melatonin and its MT2 receptor in the modulation of caerulein-induced pancreatitis in the rat.
    Autorzy: Jaworek J., Konturek S[tanisław] J., Leja-Szpak A., Nawrot K., Bonior J., Tomaszewska R., Stachura J., Pawlik W. W.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 2) s.791-804, il., tab., bibliogr. 55 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The present study investigated the involvement of endogenous melatonin in the prevention of pancreatic damage provoked by caerulein-induced pancreatitis (CIP) by using the luzindole, the antagonist of melatonin MT2 receptors. CIP was produced by subcutaneous infusion of caerulein to conscious rats (25 ćg/kg). Luzindole (1, 2 or 4 mg/kg) was given as an intraperitoneal bolus injection 30 min prior to the start of CIP. Lipid peroxidation products, malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) were measured in the pancreas by LPO-584 commercial kit. CIP was confirmed by histological examination and manifested by significant increases of plasma activities of amylase, lipase and tumor necrosis factor ŕ (TNFŕ) (by 500 p.c., 1000 p.c. and 600 p.c., respectively) comparing to the control values. This was accompanied by a 40 p.c. limitation in pancreatic blood flow (PBF) and by 200 p.c. increase of MDA + 4-HNE in the pancreas of CIP rats. Administration of luzindole to the CIP rats reduced PBF, aggravated the histological manifestations of pancreatitis, resulted in the significantaugmentation of pancreatic MDA + 4-HNE content, and produced the marked increases of plasma levels of lipase, amylase and TNFŕ, comparing to the values observes in the rats with CIP alone. These results suggest that endogenous melatonin through its receptor MT2, plays important role in the attenuation of pancreatic damage produced by overstimulation with caerulein.

    32/32

    Tytuł oryginału: Rola produktów cyklooksygenazy COX-1 i COX-2 oraz niesteroidowych leków przeciwzapalnych w mechanizmach obronnych błony śluzowej żołądka.
    Tytuł angielski: Role of cyclooxygenase COX-1 and COX-2 products in the mechanisms of gastric mucosal defense.
    Autorzy: Brzozowski Tomasz, Kwiecień Sławomir, Konturek Stanisław, Drozdowicz Danuta, Pajdo Robert, Mierzwa Marzena
    Źródło: Probl. Ter. Monitor. 2002: 13 supl. 1: VII Zjazd Towarzystwa Terapii Monitorowanej s.12-22, il., bibliogr. 39 poz., sum. - 7 Zjazd Towarzystwa Terapii Monitorowanej pt. Farmakoterapia skuteczna i bezpieczna Spała 13-15.09. 2001
    Sygnatura GBL: 312,913

    Hasła klasyfikacyjne GBL:
  • farmacja
  • gastroenterologia
  • toksykologia

    Typ dokumentu:
  • praca związana ze zjazdem

    Wskaźnik treści:
  • ludzie

    Streszczenie polskie: Celem pracy jest przedstawienie ważniejszych aspektów fizjologicznych oraz mechanizmu gastropatii związanej z NLPZ oraz z interakcji tych leków z infekcją Helicobacter pylori u ludzi i zwierząt na podstawie wybranych badań klinicznych i doświadczalnych. Specjalną uwagę poświęcono nowym kierunkom badań, zmierzającym do ograniczenia ryzyka skutków ubocznych w postaci krwawienia i uszkodzeń błony śluzowej górnego odcinka przewodu pokarmowego, wynikających z terapii.

    Streszczenie angielskie: In the review, we discuss several aspects of NSAID-induced gastropathy in human and experimental animals with or without Helicobacter pylori infection, with special focus to new strategies that could be beneficial in limiting the risk for bleedings and gastric erosions caused by traditional NSAID.

    stosując format: