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Zapytanie: KOCHEL
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Tytuł oryginału: Drug-induced liver damage - a three-year study of patients from one gastroenterological department.
Autorzy: Hartleb Marek, Biernat Łukasz, Kochel Anna
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR292-CR296, tab., bibliogr. 22 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • toksykologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Bakcground: The aim of our study was to analyze drug-induced liver disease over a 3-year period in one gastroenterological department. Material/Methods: International consensus standard definitions and criteria for assessing causality of adverse drug reactions were applied to all patients with abnormal hepatic test results. Results: Drugs were implicated in hepatic injury in 14 patietns (8 females) in whom causal relationship between drug and liver disease was definite or highly probable. The drugs responsible were amoxicillin with clavulanic acid (3 cases), fluvastatin and pravastatin (3 cases), antituberculous drugs (2 cases), estrogens, roxithromycin, asacol, satolol, enalapril and thiamazol. A total of 78.6 p.c. (11 cases) were classified as hepatocellular or mixed hepatitis, while cholestatic injury was found in 21.4 p.c. (3 cases). There were no lethal or severe (prothrombin 50 p.c.) hepatic drug reactions. In 13 patietns the course of liver disease after with drawal of the offensive drug was either acute or protracted, while in one patient there was chronic cholestasis ( 3 years) resulting from injury to interlobular bile ducts by amoxicllin with clavulanic acid. Conclusion: A thorough history of drug intake should be taken in all patients presenting with abnormal hepatic test results. Amoxicillin & clavulanic acid, cholesterol-lowering and antituberculin drugs were the most frequent hepatotoxic factors in our patients. In a majority of cases the liver injury was not severe, and resolved after prompt withdrawal of the responsible drug.

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