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KOŁTAN
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Tytuł oryginału:
Course of viral hepatitis B and combined B and C hepatitis in children treated for neoplastic diseases.
Autorzy:
Kołtan
Sylwia,
Wysocki
Mariusz,
Kołtan
Andrzej,
Świątkiewicz
Violetta,
Styczyński
Jan,
Dębski
Robert,
Balcar-Boroń
Anna
Źródło:
Med. Sci. Monitor 2002: 8 (4) s.CR274-CR279, il., tab., bibliogr. 36 poz.
Sygnatura GBL:
313,278
Hasła klasyfikacyjne GBL:
pediatria
toksykologia
mikrobiologia
gastroenterologia
onkologia
Typ dokumentu:
praca kliniczna
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
niemowlęta
dzieci 2-5 r.ż.
dzieci 6-12 r.ż.
dzieci 13-18 r.ż.
płeć męska
płeć żeńska
Streszczenie angielskie:
Background: Viral hepatitis C in children is milder than in adults. Patients with tumors, because of immune deficits, seem to be at risk of rapid liver disease progression. Little is known about the course of HCV and dual HBV-HCV infections in such patients. Material/Methods: The study assessed clinical courses of HCV and dual HBV-HCV infections in 249 children with tumors aged 1-18 years, divided into four groups: with HCV infection - 53, HBV-HCV infection - 53, HBV only - 33 and ifection-free - 110. Results: Hepatitis C was often chronic - in 83.3 p.c of patients with HCV and 77.3 p.c. of those with dual infection. Over 80 p.c. had no jaundice. Mean AIAT activity was the highest in the HCV group (149.2 ń 202.7 IU/l), lower in the dual infection group (123.3 ń 148.1 IU/l; p 0.02), and the lowest in HBV (92.7 152.9 IU/l. Transaminasemia course in patients with HCV and dual HBV-HCV infections was most frequently fluctuating (50.9 p.c. and 45.3 p.c., respectively). 52.8 p.c. of children with HCV demonstrated no advanced inflammatory lesions with invasion of the lamina limitans, no marked fibrosis, and minimum changes in descriptive classification. In 92.3 p.c. of children with dual infections, inflammatory activity was mild or mean, with no fibrosis in 61.5 p.c., and persistnet chronic inflammation predominant in descriptive classification (46.2 p.c.). Conclusions: HCV an HBV-HCV infections in children with neoplastic diseases tend to take chronic forms, but their clinical course is mild with signs of severeinflammatory activity or hepatitic strom aremodeling observed on histopathology.
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