Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: KOŁOMECKI
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: Angiogenesis of endocrine gland tumours - new molecular targets in diagnostics and therapy.
Autorzy: Stępień H. M., Kołomecki K., Pasieka Z., Komorowski J., Stępień T., Kuzdak K.
Źródło: Eur. J. Endocrinol. 2002: 146 (2) s.143-151, tab., bibliogr. 96 poz.
Sygnatura GBL: 301,344

Hasła klasyfikacyjne GBL:
  • endokrynologia
  • onkologia

    Typ dokumentu:
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Angiogenesis in one of the key stages in the development of neoplastic tumours, in which a small group of mutated cells transforms into a large malignant tumour metastasising to the neighbouring tissues and organs. The studies on the significance of neoangiogenesis in the progression of endocrine gland neoplasms have recently become one of the most rapidly evolving branches of molecular endocrinology. The induction of angiogenesis has been demonstrated to result from the imbalance between positive and negative factors which control this process. Our paper presents the results of current studies on the role of factors such as molecular markers of angiogenesis (e.g. vascular endothelial growth factor and basic fibroblast growth factor), metalloproteinases (which regulate the decomposition of the extracellular matrix) and their inhibitors, and adhesive molecules (e.g. soluble vascular cellular adhesion molecule-1 and soluble intracelular adhesion lecule-1) in the pathogenesis and diagnostics of endocrine gland tumours in humans. Also, we discuss new therapeutic strategies for inhibiting the growth of neoplasms by blocking the formation of blood vessels using angiogenesis antagonists, which inhibit various stages of angiogenesis. More and more data are being accumulated suggesting that these preparations could, in the near future, be used in the pharmacotherapy of some endocrine gland neoplasms.

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    Tytuł oryginału: Case of Cushing's syndrome due to ACTH-independent bilateral micronodular adrenal hyperplasia presenting as a severe myopathy with diaphragm atrophy.
    Autorzy: Kaźmierczak Sylwia F., Zieleniewski Wojciech, Kołomecki Krzysztof, Kunert-Radek Jolanta
    Źródło: Case Rep. Clin. Pract. Rev. 2002: 3 (1) s.8-11, il., tab., bibliogr. 11 poz.
    Sygnatura GBL: 313,612

    Hasła klasyfikacyjne GBL:
  • endokrynologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć żeńska

    Streszczenie angielskie: Background: The most typical presentation of Cushing's syndrome includes truncal obesity, purple skin striae, moon face, emotional and sleep disturbances, plethora and proximal muscle weakness. ACTH-independent micronodular adrenocortical hyperplasia (AIMAH) is a rare cause of Cushing's syndroeme with male predominance. We describe here a female patient with atypical Cushing's syndrome due to AIMAH presenting as a severe myopathy with diapghragm atrophy. Case report: A 56-year-old female suffered from hypertension, NIDDM, central adiposity and muscle weakness for 5 years, but her appearance was not typically cushingoid. She was admitted to hospital because of respiratory insufficiency due to diaphragm atrophy. Reconstructive surgery of the diaphragm was performed, but without any significant improvement. Six months later, she was referred to us with suspicion of Cushing's syndrome. Her ACTH levels in plasma samples collected throughout the day were below normal. The cortisol level was at upper limit of the normal range. The plasma circadian cortisol profile was blunted and 1 mg dexamethasone did not induce any inhibition of serum cortisol. The subsequent administration of 8 mg of dexamethasone did not cause any further suppression of cortisol. While these findings were consistent with a diagnosis of adrenocortical adenoma, computed tomography demonstrated slightly enlarged, contrast-enhacned adreanls (both adrenal glands). Results: ACTH-independent Cushing's syndrome was diagnosed and the patient underwent bilateral adrenalectomy. Histological studies revealed bilateral micronodular adrenal hyperplasia. Soon after the surgery the woman became hypoadrenal...

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