Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
Zapytanie:
KAZIMIERCZUK
Liczba odnalezionych rekordów:
6
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1/6
Tytuł oryginału:
Antimicrobial acitivity of substituted 2-trifluoromethyl- and 2-pentafluoroethylbenzimidazoles.
Autorzy:
Wolinowska
Renata,
Zajdel-Dąbrowska
Jolanta,
Starościak
Bohdan J.,
Kazimierczuk
Zygmunt
Źródło:
Acta Microbiol. Pol. 2002: 51 (3) s.265-273, il., tab., bibliogr. [16] poz.
Sygnatura GBL:
302,697
Hasła klasyfikacyjne GBL:
mikrobiologia
farmacja
Typ dokumentu:
praca doświadczalna
tytuł obcojęzyczny
Streszczenie angielskie:
Antibacterial and antifungal activity of 2-trifluoromethyl- and 2-pentafluoroethylbenzimidazoles, including a number of newly obtained derivatives, were examined by diffusion method (inhibition area diameter in solid agar medium) and minimum inhibitory concentration (MIC, in liquid and agar medium). Some of the derivatives tested affected fungal colonymorphology and exerted genotoxic effects in bacteria. Of the tested compounds, 5,6-dichlorosubstituted derivatives appeared the most active against the majority of microorganisms used.
2/6
Tytuł oryginału:
5' - Esters of 2'-deoxyadenosine and 2-chloro-2'-deoxyadenosine with cell differentiation-provoking agents.
Autorzy:
Grieb
Paweł,
Kryczka
Tomasz,
Wójtowicz
Radosław,
Kawiak
Jerzy,
Kazimierczuk
Zygmunt
Źródło:
Acta Bioch. Pol. 2002: 49 (1) s.129-137, il., bibliogr. 20 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
Sygnatura GBL:
303,116
Typ dokumentu:
praca związana ze zjazdem
praca doświadczalna
tytuł obcojęzyczny
Streszczenie angielskie:
Phenylacetic and retinoic acids are carboxyacidic cell differentiating agents displaying anticancer activities. We report on a new class of compounds including the 5'-esters of 2'-deoxyadenosine (dA) or 2-chloro-2'-deoxyadenosine (cladribine, 2CdA) and the aforementioned acids. The rationale behind the synthesis of these esters was that if they are hydrolyzed inside the lymphoid cells, either dA will be removed from the intracellular environment by deamination, or 2CdA will be phosphorylated and accumulated. In either case targetted delivery of the differentiating agent to the lymphoid cells may be envisaged. The said compounds were synthesized by the Mitsunobu procedure employing triphenylphosphine and azadircarboxylic acid esters, and their stability was tested against various esterases. Esters of dA and 2CdA with phenylacetic acids were found to be resistant to enzymatic hydrolysis, whereas those with retinoic acids were efficiently hydrolyzed by commercially available hepatic esterase as well as by esterases present in the blood plasma and in diluted human lymphocyte lysate. Susceptibility to enzymatic hydrolysis was found to be a prerequisite of cytotoxic and/or differentiating activity of these esters in leukemic cell lines.
3/6
Tytuł oryginału:
Synthesis, antiprotozoal and antibacterial activity of nitro- and halogeno-substituted benzimidazole derivatives.
Autorzy:
Kazimierczuk
Zygmunt,
Upcroft
Jacqueline A.,
Upcroft
Peter,
Górska
Agata,
Starościak
Bohdan,
Laudy
Agnieszka
Źródło:
Acta Bioch. Pol. 2002: 49 (1) s.185-195, il., tab., bibliogr. 20 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
Sygnatura GBL:
303,116
Hasła klasyfikacyjne GBL:
mikrobiologia
farmacja
Typ dokumentu:
praca związana ze zjazdem
praca doświadczalna
tytuł obcojęzyczny
Streszczenie angielskie:
Two series of benzimidazole derivatives were synthesised. The first one was based on 5,6-dinitrobenzimidazole, the second one comprises 2-thioalkyl- and thioaryl-substituted modified benzimidazoles. Antibacterial and antiprotozoal activity of the newly obtainned compounds was studied. Some thioalkyl derivatives showed remarkable activity against nosocomial strains of Stenotrophomonas malthophilia, and an activity comparable to that of metronidazole agains Gram-positive and Gram-negative bacteria. Of the tested compounds, 5,6-dichloro-2-(4-nitrobenzylthio)-benzimidazole sowed the most distinct antiprotozoal activity.
4/6
Tytuł oryginału:
Synthesis, antiprotozoal and anticancer activity of substituted 2-trifluoromethyl- and 2-pentafluoroethylbenzimidazoles.
Autorzy:
Andrzejewska
Mariola,
Ypez-Mulia
Lilian,
Cedillo-Rivera
Roberto,
Tapia
Amparo,
Vilpo
Leena,
Vilpo
Juhani,
Kazimierczuk
Zygmunt
Źródło:
Eur. J. Med. Chem. 2002: 37 (12) s.973-978, il., tab., bibliogr. 18 poz.
Sygnatura GBL:
312,629
Hasła klasyfikacyjne GBL:
mikrobiologia
farmacja
Typ dokumentu:
praca doświadczalna
praca opublikowana za granicą
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
in vitro
Streszczenie angielskie:
The synthesis of several halogenated benzimidazoles substituted in position 2 with trifluoromethyl, pentafluoroethyl and 2-thioethylaminodimethyl group is reported. Antiprotozoal and anticancer activity of series of newly synthesized and previously obtained compounds was studied. All of tested bezimidazoles showed remarkable antiprotozoal activity against Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. Of the studied collection of halogenated benzimidazoles the most anticanceractive was the 5,6-dichloro-2-pentafluoroethyl compound, particularly against breast and prostate cancer cell lines.
5/6
Tytuł oryginału:
Terminalna postać zwyrodnienia barwnikowego siatkówki - opis przypadku.
Tytuł angielski:
Final state of retinitis pigmentosa - case report.
Autorzy:
Kazimierczuk
Krystyna,
Robaszkiewicz
Jacek,
Stankiewicz
Andrzej
Źródło:
Okulistyka 2002: 5 (4) s.60-63, il., bibliogr. 10 poz., sum.
Sygnatura GBL:
313,465
Hasła klasyfikacyjne GBL:
okulistyka
Wskaźnik treści:
ludzie
Streszczenie angielskie:
Retinitis pigmentosa is genetically determined disease. It leads to a total blindness in final states. We don't have a specificial treatment now, but development of a new genetic technics might have improve the standard patient's live.
6/6
Tytuł oryginału:
Synthesis and biological properties of S-adamantylated heterocyclic compounds.
Autorzy:
Górska
Agata,
Świtaj
Tomasz,
Młynarczuk
Izabela,
Lasek
Witold,
Kazimierczuk
Zygmunt
Źródło:
Acta Pol. Pharm. 2002: 59 (6) s.415-417, il., tab., bibliogr. 13 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
Sygnatura GBL:
301,378
Hasła klasyfikacyjne GBL:
farmacja
onkologia
Typ dokumentu:
praca związana ze zjazdem
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
myszy
in vitro
Streszczenie angielskie:
A series of new S-adamantylated compounds were prepared by adamantyl cation attack on the thiol group. The biological activity of new compounds as the inducers of TNF-ŕ in genetically modified mouse melanoma cells is presented.
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