Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: KAZIMIERCZUK
Liczba odnalezionych rekordów: 6



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Tytuł oryginału: Antimicrobial acitivity of substituted 2-trifluoromethyl- and 2-pentafluoroethylbenzimidazoles.
Autorzy: Wolinowska Renata, Zajdel-Dąbrowska Jolanta, Starościak Bohdan J., Kazimierczuk Zygmunt
Źródło: Acta Microbiol. Pol. 2002: 51 (3) s.265-273, il., tab., bibliogr. [16] poz.
Sygnatura GBL: 302,697

Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Antibacterial and antifungal activity of 2-trifluoromethyl- and 2-pentafluoroethylbenzimidazoles, including a number of newly obtained derivatives, were examined by diffusion method (inhibition area diameter in solid agar medium) and minimum inhibitory concentration (MIC, in liquid and agar medium). Some of the derivatives tested affected fungal colonymorphology and exerted genotoxic effects in bacteria. Of the tested compounds, 5,6-dichlorosubstituted derivatives appeared the most active against the majority of microorganisms used.


    2/6

    Tytuł oryginału: 5' - Esters of 2'-deoxyadenosine and 2-chloro-2'-deoxyadenosine with cell differentiation-provoking agents.
    Autorzy: Grieb Paweł, Kryczka Tomasz, Wójtowicz Radosław, Kawiak Jerzy, Kazimierczuk Zygmunt
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.129-137, il., bibliogr. 20 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Phenylacetic and retinoic acids are carboxyacidic cell differentiating agents displaying anticancer activities. We report on a new class of compounds including the 5'-esters of 2'-deoxyadenosine (dA) or 2-chloro-2'-deoxyadenosine (cladribine, 2CdA) and the aforementioned acids. The rationale behind the synthesis of these esters was that if they are hydrolyzed inside the lymphoid cells, either dA will be removed from the intracellular environment by deamination, or 2CdA will be phosphorylated and accumulated. In either case targetted delivery of the differentiating agent to the lymphoid cells may be envisaged. The said compounds were synthesized by the Mitsunobu procedure employing triphenylphosphine and azadircarboxylic acid esters, and their stability was tested against various esterases. Esters of dA and 2CdA with phenylacetic acids were found to be resistant to enzymatic hydrolysis, whereas those with retinoic acids were efficiently hydrolyzed by commercially available hepatic esterase as well as by esterases present in the blood plasma and in diluted human lymphocyte lysate. Susceptibility to enzymatic hydrolysis was found to be a prerequisite of cytotoxic and/or differentiating activity of these esters in leukemic cell lines.


    3/6

    Tytuł oryginału: Synthesis, antiprotozoal and antibacterial activity of nitro- and halogeno-substituted benzimidazole derivatives.
    Autorzy: Kazimierczuk Zygmunt, Upcroft Jacqueline A., Upcroft Peter, Górska Agata, Starościak Bohdan, Laudy Agnieszka
    Źródło: Acta Bioch. Pol. 2002: 49 (1) s.185-195, il., tab., bibliogr. 20 poz. - 8 Międzynarodowe Sympozjum pt. Aspekty molekularne chemioterapii Gdańsk 09. 2001
    Sygnatura GBL: 303,116

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Streszczenie angielskie: Two series of benzimidazole derivatives were synthesised. The first one was based on 5,6-dinitrobenzimidazole, the second one comprises 2-thioalkyl- and thioaryl-substituted modified benzimidazoles. Antibacterial and antiprotozoal activity of the newly obtainned compounds was studied. Some thioalkyl derivatives showed remarkable activity against nosocomial strains of Stenotrophomonas malthophilia, and an activity comparable to that of metronidazole agains Gram-positive and Gram-negative bacteria. Of the tested compounds, 5,6-dichloro-2-(4-nitrobenzylthio)-benzimidazole sowed the most distinct antiprotozoal activity.


    4/6

    Tytuł oryginału: Synthesis, antiprotozoal and anticancer activity of substituted 2-trifluoromethyl- and 2-pentafluoroethylbenzimidazoles.
    Autorzy: Andrzejewska Mariola, Y‚pez-Mulia Lilian, Cedillo-Rivera Roberto, Tapia Amparo, Vilpo Leena, Vilpo Juhani, Kazimierczuk Zygmunt
    Źródło: Eur. J. Med. Chem. 2002: 37 (12) s.973-978, il., tab., bibliogr. 18 poz.
    Sygnatura GBL: 312,629

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: The synthesis of several halogenated benzimidazoles substituted in position 2 with trifluoromethyl, pentafluoroethyl and 2-thioethylaminodimethyl group is reported. Antiprotozoal and anticancer activity of series of newly synthesized and previously obtained compounds was studied. All of tested bezimidazoles showed remarkable antiprotozoal activity against Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. Of the studied collection of halogenated benzimidazoles the most anticanceractive was the 5,6-dichloro-2-pentafluoroethyl compound, particularly against breast and prostate cancer cell lines.


    5/6

    Tytuł oryginału: Terminalna postać zwyrodnienia barwnikowego siatkówki - opis przypadku.
    Tytuł angielski: Final state of retinitis pigmentosa - case report.
    Autorzy: Kazimierczuk Krystyna, Robaszkiewicz Jacek, Stankiewicz Andrzej
    Źródło: Okulistyka 2002: 5 (4) s.60-63, il., bibliogr. 10 poz., sum.
    Sygnatura GBL: 313,465

    Hasła klasyfikacyjne GBL:
  • okulistyka

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Retinitis pigmentosa is genetically determined disease. It leads to a total blindness in final states. We don't have a specificial treatment now, but development of a new genetic technics might have improve the standard patient's live.


    6/6

    Tytuł oryginału: Synthesis and biological properties of S-adamantylated heterocyclic compounds.
    Autorzy: Górska Agata, Świtaj Tomasz, Młynarczuk Izabela, Lasek Witold, Kazimierczuk Zygmunt
    Źródło: Acta Pol. Pharm. 2002: 59 (6) s.415-417, il., tab., bibliogr. 13 poz. - 3 Multidyscyplinarna Konferencja nt. badań nad lekami Piła 13-16.05. 2002
    Sygnatura GBL: 301,378

    Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • in vitro

    Streszczenie angielskie: A series of new S-adamantylated compounds were prepared by adamantyl cation attack on the thiol group. The biological activity of new compounds as the inducers of TNF-ŕ in genetically modified mouse melanoma cells is presented.

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