Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: KAPUŚCIŃSKI
Liczba odnalezionych rekordów: 5



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1/5

Tytuł oryginału: The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. P. 1: Reduction of cytostatic effects of quinacrine mustard by caffeine.
Autorzy: Kapuściński Jan, Ardelt Barbara, Piosik Jacek, Zdunek Małgorzata, Darzynkiewicz Zbigniew
Źródło: Biochem. Pharmacol. 2002: 63 (4) s.625-634, il., tab., bibliogr. 45 poz.
Sygnatura GBL: 304,395

Hasła klasyfikacyjne GBL:
  • genetyka
  • farmacja

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Recently, accumulated statistical data indicate the protective effect of caffeine consumption against several types of cancer diseases. There are also reports about protective effect of caffeine and other xanthines against tumors induced by polycyclic aromatic hydrocarbons. One of the explanations is based on biological activation of such carcinogens by cytochromes that are also known for metabolism of caffeine. However, there is also numerous data indicating reverse effect on cytotoxicity of anticancer drugs that inhibit the action of topoisomerase I (e.g. Camptothecin or Topotecan) and topoisomerase II inhibitors (e.g. Doxorubicin, Mitoxantrone or mAMSA). In this work we tested the hypothesis that the caffeine protective effect is the result of sequestering of aromatic mutagens by formation of stacking (ă - ă) complex. As the models for the study we have chosen two well-known mutagens, that do not require metabolic activation: quinacrine mustard (QM, aromatic, heterocyclic nitrogen mustard) and mechlorethamine (NM2, aliphatic nitrogen mustard). The flow cytometry study of these agents' action on the cell cycle of HL-60 cells indicated that caffeine prevents the cytotoxic action of QM, but not that of NM2. The formations of stacking complexes of QM with caffeine were confirmed by light absorption, calorimetric measurements and by molecular modeling calculation. Using the statistical thermodynamics calculations we calculated the "neighborhood" association constant (KAC = 59 ń 2 M**-1) and enthalpy change (DeltaH**0' = -116 cal mol**-1); the favorable entropy change of complex formation (DeltaS**0' = 7.72 cal mol**-1 K**-1, ...


    2/5

    Tytuł oryginału: The modulation by xanthines of the DNA-damaging effect of polycyclic aromatic agents. P. 2: The stacking complexes of caffeine with doxorubicin and mitoxantrone.
    Autorzy: Piosik Jacek, Zdunek Małgorzata, Kapuściński Jan
    Źródło: Biochem. Pharmacol. 2002: 63 (4) s.635-646, il., tab., bibliogr. 45 poz.
    Sygnatura GBL: 304,395

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: Recently accumulated statistical data indicate the protective effects of caffeine consumption against several types of cancer diseases. There are also reports, about protective effect of caffeine and other xanthines against tumors induced by polycyclic aromatic hydrocarbons. One of the explanations of this phenomenon is based on biological activation of such carcinogens by cytochromes that are also known for metabolism of caffeine. In the accompanying paper [Kapuścinski et al., this issue] we provide evidence (flow cytometry and the cell cycle analysis) that the cytostatic effects of caffeine (CAF) on two DNA alkylating agents, which do not require the biological activation, depend on their ability to form stacking (ă - ă) complex. In this study, we use physicochemical techniques (computer aided light absorption and microcalorimetry), and molecular modeling to examine previously published qualitative data. This is published both by our and other group's data, indicates that CAF is able to modify the cytotoxic and/or cytostatic action of the two well known antitumor drugs doxorubicin (DOX) and mitoxantrone (MIT). To obtain the quantitative results from the experimental data we used the statistical-thermodynamical model of mixed aggregation, to find the association constants KAC of the CAF-drug interaction (128 ń 10 and 356 ń 21 M**-1 for DOX-CAF and MIT-CAF complex formation, respectively). In addition, the favorable enthalpy change of CAF-MIT (DeltaH = -11.3 kcal/mol) was measured by microcalorimetry titration. The molecular modeling (semi-empirical and force field method)...


    3/5

    Tytuł oryginału: Ocena rozwarstwień aorty brzusznej w badaniach MR i USG.
    Tytuł angielski: Magnetic resonance imaging and ultrasound examination in the evaluation of abdominal aortic dissection.
    Autorzy: Zdziarska-Grzybowska Monika, Michałowska Ilona, Kapuściński Olgierd, Meszaros-Tutak Agnieszka, Sieklicki Marek, Janaszek-Sitkowska Hanna
    Źródło: Pol. J. Radiol. 2002: 67 (3) s.19-22, il., tab., bibliogr. 7 poz., sum.
    Sygnatura GBL: 301,279

    Hasła klasyfikacyjne GBL:
  • radiologia
  • kardiologia

    Typ dokumentu:
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Abdominal aortic dissection result from the separation of the intima by a blood stream penetrating through disrupted intima. The abdominal aortic dissection is most often caused by the injury of the thoracic aorta. The objective of the study was to assess the abdominal aorta with US and MR in the patients after surgery of the dissection of ascending aorta. Material/Methods: One hundred fifteen patients operated for acute aortic disection of the A type have been observed. In all patients US and MR of the abdomen have been performed. MR examinations were made in the T1 SE sequence in three planes. Ultrasound examinations were made using convex 3.5 MHz probe with optional color Doppler. The diameter of the aorta, presence of intima, extend of the tear, presence of thrombi, flow in both lumens have been assessed. Results: Consistence of the diagnosis in MR and US was achieved in 91 cases (79 p.c.), different results in 24 cases (21 p.c.). Two false positive and ten false negative diagnoses of the dissection in US were noted. In 9 US examinations no broadening of the aorta have been found Thrombi in the false lumen have been described based on MR in 20 cases and based on US in 8 cases. Conclusions: MR and US are complementary modalities in the diagnostics of abdominal aorta. MR is a sensitive method in the diagnostics and assessment of the extend of the dissection. The presence of thrombi and the flow can be assessed easier in US.


    4/5

    Tytuł oryginału: Pęcherzyk żółciowy w niewydolności serca - opis przypadku.
    Tytuł angielski: Gallbladder in heart failure - case report.
    Autorzy: Zdziarska-Grzybowska Monika, Meszaros-Tutak Agnieszka, Kapuściński Olgierd, Sieklicki Marek, Michałowska Ilona
    Źródło: Pol. J. Radiol. 2002: 67 (4) s.85-86, il., bibliogr. 5 poz., sum.
    Sygnatura GBL: 301,279

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • kardiologia
  • radiologia

    Typ dokumentu:
  • praca kazuistyczna

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: This paper presents the case of 59 years old female diagnosed with atrial fibrillation and cardiac insufficiency on admission to our Institute. Due to complaints of abdominal pain, US examination was performed and it revealed a gallbladder wall thickening. Clinical parameters and ultrasound findings suggested cholecystitis, however there were no abnormalities in control sonograms after successful pharmacological conversion to the sinus cardiac rhythm.


    5/5

    Tytuł oryginału: Zasady i metody kontroli jakości radiofarmaceutyków.
    Autorzy: Kapuściński Janusz, Mikołajczak Renata
    Źródło: Probl. Med. Nukl. 2002: 16 supl. s.97-125, il., tab., bibliogr. 6 poz.
    Sygnatura GBL: 306,304

    Hasła klasyfikacyjne GBL:
  • radiologia

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