Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: JERZMANOWSKI
Liczba odnalezionych rekordów: 3



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Tytuł oryginału: Genetyka molekularna
Autorzy: Bartnik Ewa, Chorąży Mieczysław, Fikus Magdalena, Gajewski Wacław, Jachymczyk Witold, Jerzmanowski Andrzej, Krzanowska Halina, Lipińska Barbara, Ostoja-Zagórski Włodzimierz, Staroń Krzysztof, Stępień Piotr, Szala Stanisław, Taylor Alina, Taylor Karol, Węgleński Piotr
Opracowanie edytorskie: Węgleński Piotr (red.).
Wydanie: - Wyd. 5
Źródło: - Warszawa, Wydaw. Naukowe PWN SA 2002, 497, [3] s. : il., tab., 24 cm.
Sygnatura GBL: 734,936

Hasła klasyfikacyjne GBL:
  • genetyka

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    Tytuł oryginału: Biologia w erze pogenomowej.
    Tytuł angielski: Biology in postgenomic phase.
    Autorzy: Jerzmanowski Andrzej
    Źródło: Kosmos 2002: 51 (1) s.1-4, bibliogr. [5] poz., sum.
    Sygnatura GBL: 313,370

    Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca związana ze zjazdem

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: The current postgenomic phase in biology is characterized by the occurrence of numerous novel research areas. Within the next twenty years or so, some of them will probably develop into well defined sub-disciplines, the other will disappear or transform into something completely new. Of the emerging directions, three seem particulary promising. They are: comparative genomics, deep analysis of the genomes and a search for the new ways of describing organisms. The recent exemplary achievments obtained by research pursuing these directions were the elucidation of the role of segmental DNA duplications in the evolution of mammals, the discovery of the regulatory functions and the wideospread occurrence in the genomes of the tiny RNA molecules, the microRNA, and the finding that such processes as karyokinesis or nuclear-cytoplasmic transpoprt are controlled by the fields of interactions resulting form gradients of regulatory molecules.

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    Tytuł oryginału: Lymphoplasmacytic lymphoma with monoclonal gammopathy-related pseudo-gaucher cell infiltration in bone marrow and spleen-diagnostic and therapeutic dilemmas.
    Autorzy: Robak Tadeusz, Urbańska-Ryś Halina, Jerzmanowski Piotr, Bartkowiak Jacek, Liberski Paweł, Kordek Radzisław
    Źródło: Leuk. Lymphoma 2002: 43 (12) s.2343-2350, il., bibliogr. 36 poz.
    Sygnatura GBL: 312,939

    Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia

    Typ dokumentu:
  • praca kazuistyczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska

    Streszczenie angielskie: Gaucher-like cells have occasionally been described in various haematological malignancies including Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma (MM) and chronic myelogenous leukemia (CML). A special type of this phenomenon is crystal-storing histocytosis or the so-called pseudo-pseudo Gaucher cells (PPGC) in which crystalline protein storage in macrophages is induced by paraproteinemia. Here we describe a 54-year-old man with an initial suspicion of Gaucher disease and monoclonal IgA gammopathy in whom a correct diagnosis of lymphoplasmacytic lymphoma (LPL) with massive infiltration of bone marrow and spleen by PPGC was confirmed by immunological, ultrastructural and molecular characterisation. The activity of leukocyte beta-glucocerebrosidase was only slightly elevated (7.3 nmol/mg protein/1h) which ruled out the diagnosis of classic Gaucher's disease. The patient received two courses of CHOP without improvement and anti-CD20 monoclonal antibody (rituximab) with only temporary stabilisation. Subsequently, he underwent splenectomy because of prolonged severe pancytopenia and a suspicion of hypersplenism. After splenectomy significant haematological improvement was observed. Following anti-CD20 therapy, changes in immunoprofile and morphology of tumour cells were evident. Before treatment the population of LPL was more divergent, with expression of LCA, CD20, CD38 and CD138. However, after the treatment, there were more mature plasma cells which no longer expressed CD20 antigen-this picture was more consistent with the diagnosis of plasma cell myeloma...

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