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Tytuł oryginału: Relationship between acute and late normal tissue injury after postoperative radiotherapy in endometrial cancer.
Autorzy: Jereczek-Fossa Barbara A., Jassem Jacek, Badzio Andrzej
Źródło: Int. J. Radiat. Oncol. Biol. Phys. 2002: 52 (2) s.476-482, il., tab., bibliogr. 49 poz.
Sygnatura GBL: 312,578

Hasła klasyfikacyjne GBL:
  • ginekologia i położnictwo
  • onkologia
  • radiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Purpose: To evaluate the relationship between acute and late normal tissue reaction in 317 consecutive endometrial cancer patients treated with surgery and adjuvant radiotherapy (RT). Methods: The data of 317 patients (staging according to the International Federation of Gynecology and Obstetrics) treated with postoperative RT were analyzed. Both low-dose-rat brachytherapy and external beam RT were applied in 247 patients (78 p.c.); brachytherapy only in 49 (15 p.c.) and external beam irradiation only in 21 (7 p.c.). The median follow-up was 7.3 years (range 4-21). The European Organization for Research and Treatment of Cancer, Radiation Therapy Oncology Group system with elements of the late effects of normal tissue, sibjective, objective, management, analytic (LENT/SOMA) scale was used to score the RT reactions. The correlation between the occurrence and severity of acute and late bowel and bladder toxicity, as well as the relationship between the severity of acute effects and time to occurrence of late reactions, were assessed using linear and logistic regression analyses. Results: Of the 317 patients, 268 (85 p.c.) experienced acute RT reactions of any grade. Severe acute bowel reactions were observed in 15 patients (5 p.c.), urinary bladder complications in 1 patient (0.5 p.c.) cutaneous in 1 patient (0.5 p.c.), and vaginal in 1 patient (0.5 p.c.). Severe acute hematologic toxicity was seen in 3 patients (1 p.c.). A total of 158 patients (51 p.c.) experienced late RT reactions of any grade. Severe late bowel reactions were obsrved in 19 patients (6 p.c.), urinary bladder in 5 (2 p.c.), vaginal in 3 (1 p.c.), and bone in 10 (4 p.c.)...

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