Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
Zapytanie:
JAYARAMAN
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1
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Tytuł oryginału:
Preparation and characterization of two new composites: collagen-brushite and collagen octa-calcium phosphate.
Autorzy:
Jayaraman
Mythili,
Subramanian
Manicka Velayudham
Źródło:
Med. Sci. Monitor 2002: 8 (11) s.BR481-BR487, il., bibliogr. 37 poz.
Sygnatura GBL:
313,278
Hasła klasyfikacyjne GBL:
traumatologia i ortopedia
Typ dokumentu:
tytuł obcojęzyczny
praca doświadczalna
Wskaźnik treści:
zwierzęta
in vitro
bydło
Streszczenie angielskie:
Background: Recent studies have focussed on understanding the fundamental aspects of mineralization, searching for insight into the physical and chemical interactions between the organic and inorganic counterparts in bio-inorganic composites. Structural alterations in organic matrices interacting with minerals during the phase transition form un-calcified to calcified affect the mineral micro-environment, resulting in calcification. The present study deals with the fabrication of two novel bio-inorganic composites: collagen-brushite and collagen-octacalsium phosphate. The mineral conterparts are grown onto collagen by crystal growth, to produce composites adaptaed to the ambient environment in bone, at pH 5.8 and pH 7.0. The biophysical and material characteristics provide some interesting insights into calcifying mechanisms. Matiral/Methods: The biophysical parameters were evaluated by Fourier Transform Infra Red (FTIR) spectroscopic studies, Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopic (SEM) studies, with biochemical characterization of demineralized and remineralized samples for hydroxyproline, hexosamine, uronic acid, and net protein content. Results: THe biochemical characterization of demineralized and remineralized samples revealed protein loss on mineralization and indicated the possible role of non-collagenous proteins (osteonectin) in mineralization. The FTIR spectra showed loss of amide peaks, while DSC and SEM studies showed closer association of collagen with the mineral counterpart...
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