Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: JARZYNA
Liczba odnalezionych rekordów: 2



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Tytuł oryginału: Inhibition of gluconeogenesis by vanadium and metformin in kidney-cortex tubules isolated from control and diabetic rabbits.
Autorzy: Kiersztan Anna, Modzelewska Aleksandra, Jarzyna Robert, Jagielska Elżbieta, Bryła Jadwiga
Źródło: Biochem. Pharmacol. 2002: 63 (7) s.1371-1382, il., tab., bibliogr. 75 poz.
Sygnatura GBL: 304,395

Hasła klasyfikacyjne GBL:
  • endokrynologia
  • farmacja
  • nefrologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • króliki

    Streszczenie angielskie: Effect of vanadyl acetylacetonate (VAc) and metformin on gluconeogenesis has been studied in isolated hepatocytes and kidney-cortex tubules of rabbit. Glucose formation from alanine + glycerol + octanoate, pyruvate or dihydroxyacetone was inhibited by 50-80 p.c. by 100 ćM VAc or 500 ćM metformin in renal tubules of control and alloxan-diabetic animals, while the inhibitory action of these compounds in hepatocytes was less pronounced (by about 20-30 p.c.). In contrast to VAc, metaformin increased the rate of lactate formation by about 2-fold in renal tubules incubatet with alanine + glycerol + octanoate. In view of VAc-induced changes in intracellular gluconeogenic intermediates and gluconeogenic enzyme activities, it is likely taht this compound may decrease fluxes through pyruvate carboxylase, phosphoenolpyruvate carboxykinase, fructose-1,6-bisphosphatase and glucose-6-phosphatase. In contrast to VAc, metformin-induced decrease in renal gluconeogenesis may result from a decline of cytosolic oxaloacetate level and consequently PEPCK activity. Following 6 days of VAc administration (1.275 mg V kg-1 body weight daily) the blood glucose level in alloxan-diabetic rabbits was normalised while blood glucose changes in control animals were not observed. On the contrary, in diabetic animals treated for 6 days with metformin (200 mg kg-1 body weight day -1) a high blood glucose level was maintained. Unfortunately, VAc-treated control and diabetic rabbits exhibited elevated serum urea and creatinine levels. In VAc-treated animals vanadium was accumulated in kidney=cortex up to 7.6 ń 0.6 ćg V g-1 dry weight. In view of a potential vanadium nephrotoxicity...

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    Tytuł oryginału: Chlorochina - wszechstronne właściwości leku przeciwmalarycznego.
    Tytuł angielski: Chloroquine: miscellaneous properties of the antimalarial drug.
    Autorzy: Jarzyna Robert
    Źródło: Post. Hig. 2002: 56 (2) s.169-184, il., bibliogr. [101] poz., sum.
    Sygnatura GBL: 301,727

    Hasła klasyfikacyjne GBL:
  • farmacja
  • toksykologia

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Chloroquine is a drug with over 60 years of safe clinical use in the treatment of malaria. The multiple mechanisms of chloroquine action have appeared to be useful in the therapy of many miscellaneous disorders well beyond its original antimalarial purposes. This paper is focused on the application of chloroquine for the treatment of malaria, porphyria cutanea tarda, rheumatoid arthritis, palindromic rheumatism and lupus. The possibility of the use of chloroquine in the therapy of other disorders such as diabetes mellitus, AIDS, hyperlipidemia, sarcoidosis, hypercalcemia, and melanoma is reviewed. Mechanisms of action of the drug as well as side effects on metabolism are discussed in view of recent discoveries.

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