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JAKÓBKIEWICZ
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Tytuł oryginału:
Mutacje genów p53 i p16 w niedrobnokomórkowym raku płuca.
Tytuł angielski:
p53 and p16 gene mutations in non-small cell lung cancer.
Autorzy:
Jassem
Ewa,
Ramlau
Rodryg,
Dziadziuszko
Rafał,
Szymanowska
Amelia,
Jakóbkiewicz
Joanna,
Lamperska
Katarzyna,
Kobierska
Grażyna,
Skokowski
Jan,
Dyszkiewicz
Wojciech,
Mackiewicz
Andrzej,
Żylicz
Maciej,
Jassem
Jacek
Źródło:
Pneumonol. Alergol. Pol. 2002: 70 (1/2) s.64-70, il., tab., bibliogr. 20 poz., sum.
Sygnatura GBL:
301,096
Hasła klasyfikacyjne GBL:
genetyka
pulmonologia
onkologia
Typ dokumentu:
praca kliniczna
Wskaźnik treści:
ludzie
Streszczenie angielskie:
The aim of this study was to assess prospectively the occurrence of p53 and p16 mutations (considered separately and together) in NSCLC in terms of their clinical and prognostic relevance. Study group included 87 patients who underwent pulmonary resectiom for cure. p53 and p16 mutations were found in 22 (25 p.c.) and 14 (16 p.c.) cases, respectively. In eight patients (9 p.c.) both mutations were present, and the tendency for their common occurrence was significant (p = 0.02). There was no relation between mutation and clinical characteristics. Median survival in the entire group was 17 months and thr 3-year survival probability - 41 p.c. There was no correlation between the occurrence of many mutation (considere separately or together) and survival. Theses results indicate that p53 and p16 gene mutations tend to occur together in NSCLC, however these alterations seem not to have noteworthy clinical and prognostic significance.
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