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Tytuł oryginału: Cytotxic effect of cyclosporin A alone and in combination with 2-chlorodeoxyadenosine against P388 murine leukemia in vivo.
Autorzy: Józefowicz-Okonkwo Grażyna, Szmigielska-Kapłon Anna, Robak Tadeusz
Źródło: Med. Sci. Monitor 2002: 8 (9) s.BR373-BR377, il., tab., bibliogr. 21 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • onkologia
  • farmacja
  • hematologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć męska

    Streszczenie angielskie: Background: THe purpose of our study was to determine the antileukemic effects of cyclosporin A (CsA0 and its interaction with a new purine analogue, -chlorodeoxyadenosine (2-CdA, cladribine) on P388 murine leukemia in vivo. Material/methods: Mice were engrafted intraperitoneally (i.p.) with 10**6 P388 leukemia cells on day 0 of each step of the two-step experiment. ALl treatments were initiated on teh next day (day 1) as daily i.p. injections and lasted for five consecutive days. In the first part of the experiment, designed to establish the antileukemic effect of CsA, the mice received 10, 15, 20, 25 or 30 mg/kg of CsA. In the second part, where the interaction between CsA and 2-CdA was examined, the animals were administered CsA at a dose of 15 mg/gk, or 2-CdA at a dose of 20 mg/kg, or CsA combined with 2-CdA at the same doses as in monotherpay. Results: CsA did not influence the survival time of mice with P388 leukemia at any dose. ScA was used for the interaction study at a dosage of 15 mg/kg, as this was best tolerated by the animals. The mice treated with combination therapy using CsA and 2-CdA survived longer than those treated with 2-CdA monotehrapy (p = 0.00015). Conclusion: Our study revealed that CsA alone does not increase the survival time of mice with P388 leukemia, but it augments the antileukemic effect of 2CdA.

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