Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
Zapytanie:
IRONSIDE
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2
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Tytuł oryginału:
Neuropathology of variant Creutzfeldt-Jakob disease.
Autorzy:
Ironside
James W.,
Head
Mark W.,
McCardle
Linda,
Knight
Richard
Źródło:
Acta Neurobiol. Exp. 2002: 62 (3) s.175-182, il., tab., bibliogr. s. 181-182
Sygnatura GBL:
302,090
Hasła klasyfikacyjne GBL:
neurologia
Typ dokumentu:
praca kliniczna
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
Streszczenie angielskie:
The clinical, neuropathological genetic and biochemical features of variant Creutzfeldt-Jakob disease (vCJD) are compared to the 926 other cases of suspected CJD referred to the National CJD Surveillance Unit laboratory from 1999 - 2001. Histological studies of the central nervous system, lymphoid tissues and other organs were accompanied by immunocytochemistry for prion protein (PrP); Western blot analysis of PrP**RES was performed on frozen brain tissue. The pathology of vCJD showed relatively uniform morphological and immunocytochemical characteristics, with PrP accumulation in lymphoid tissues, but not in other non-neural tissues. PrP**RES accumulation in vCJD showed a uniform glycotype pattern distinct from sporadic CJD. All cases of vCJD were methionine homozygotes at codon 129 of the PrP gene. In view of the spread of bovine spongiform encephalopathy in Europe and Japan, continuing surveillance is required for all forms of CJD, with histological and biochemical analysis of suspected cases to allow an accurate laboratory diagnosis.
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Tytuł oryginału:
Laminar distribution of the pathological changes in the cerebral cortex in variant Creutzfeldt-Jakob disease (vCJD).
Autorzy:
Armstrong
Richard A.,
Cairns
Nigel J.,
Ironside
James W.,
Lantos
Peter L.
Źródło:
Folia Neuropathol. 2002: 40 (4) s.165-171, il., tab., bibliogr. 24 poz.
Sygnatura GBL:
304,961
Hasła klasyfikacyjne GBL:
neurologia
Typ dokumentu:
praca kliniczna
badanie porównawcze
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
dorośli 19-44 r.ż.
dorośli 45-64 r.ż.
płeć męska
płeć żeńska
Streszczenie angielskie:
To determine the pattern of cortical degeneration in cases of variant Creutzfeldt-Jakob disease (vCJD), the laminar distribution of the vacuolation ("spongiform change"), surviving neurones, glial cell nuclei, and prion protein (PrP) deposits was studied in the frontal, pariertal and temporal lobess. The vacuolation exhibited two common patterns of distribution: either the vacuoles were present throughout the cortex or a bimodal distribution was present with peaks of density in the upper and lower cortical laminae. The distribution of the surviving neurones was highly variable in different reggions; the commonest pattern being a uniform distribution with cortical depth. Glial cell nuclei were distributed largely in the lower cortical laminaee. The non-florid PrP deposits exhibited either a bimodal distribution or exhibited a peak of density in the upper cortex while the florid deposits were either uniformly distributed down the cortex or were present in the upper cortical laminae. In a significant proportion of areas, the density of the vacuoles was positively correlated with either the surviving neurones or with the glial cell nuclei. These results suggest similarities and differences in the laminar distributions of the pathogenic changes in vCJD compared with cases of sporadic CJD (sCJD). The laminar distribution of vacuoles was more extensive in vCJD than in sCJD whereas the distribution of the glial cell nuclei was similar in the two disorders, PrP deposits in sCJD were localised mainly in the lower cortical laminaee while in vCJD, PrP deposits were either...
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