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Tytuł oryginału: Prevalence of cryoglobulinemia in patients with chronic HCV infection.
Autorzy: Liakina Valentina, Speiciene Danute, Irnius Algimantas, Naraskeviciene Jolanta, Barakauskiene Ausrine, Semuchiniene Teresa
Źródło: Med. Sci. Monitor 2002: 8 (1) s.CR31-CR36, tab., bibliogr. 31
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The purpose of our research was to determine the prevalence of cryoglobulins in patients with chronic hepatitis C (CHC) at differnt levels of activity and stage of fibrosis and to identify their association with the extrahepatic clinical manifestations. Material/Methods: 87 patients with CHC were investigated for the presence of cryoglobulins. Cryocrit was measured by the Weiner method. Anti HCV, HCV RNR, conventional biochemical tests and liver biopsy were also performed. Results: Cryoglobulins were found in a total of 44 patients: 16 from Group I, II from Group II, and 17 from Group III. A low level of cryoglobulinemia (Cg) (cryocrit ó 2 p.c.) was detected in 16 patients: 9 from Group I, 3 from Group II, and 4 from Group III. Moreover, a high Cg (cryocrit 5 - 10 p.c.) or very high Cg (cryocrit 10 p.c.) was found in a total of 13 patients: 1 patient from Group I, 3 from Group II, and 9 from Group III. Cryo positivity was found in 5 patients with F 1 - 2, in 13 with F 2 - 3, in 4 with F 3 - 4, and in 17 with F 4. Conclusions: Our findings confirmed the high prevalence of Cg in CHC patients in Lithuania, a clear association between Cg and the stage of fibrosis, teh higher prevalence of Cg in cirrhotic patients, and the occurrence of several typical extrahepatic manifestations. The impact of Cg on the course of chronic hepatitis C is not clearly understood; therefore, further studies are needed to clarify this issue.

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