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Tytuł oryginału:
Prevalence of cryoglobulinemia in patients with chronic HCV infection.
Autorzy:
Liakina
Valentina,
Speiciene
Danute,
Irnius
Algimantas,
Naraskeviciene
Jolanta,
Barakauskiene
Ausrine,
Semuchiniene
Teresa
Źródło:
Med. Sci. Monitor 2002: 8 (1) s.CR31-CR36, tab., bibliogr. 31
Sygnatura GBL:
313,278
Hasła klasyfikacyjne GBL:
gastroenterologia
Typ dokumentu:
praca kliniczna
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
dorośli 19-44 r.ż.
dorośli 45-64 r.ż.
dorośli = 65 r.ż.
płeć męska
płeć żeńska
Streszczenie angielskie:
Background: The purpose of our research was to determine the prevalence of cryoglobulins in patients with chronic hepatitis C (CHC) at differnt levels of activity and stage of fibrosis and to identify their association with the extrahepatic clinical manifestations. Material/Methods: 87 patients with CHC were investigated for the presence of cryoglobulins. Cryocrit was measured by the Weiner method. Anti HCV, HCV RNR, conventional biochemical tests and liver biopsy were also performed. Results: Cryoglobulins were found in a total of 44 patients: 16 from Group I, II from Group II, and 17 from Group III. A low level of cryoglobulinemia (Cg) (cryocrit ó 2 p.c.) was detected in 16 patients: 9 from Group I, 3 from Group II, and 4 from Group III. Moreover, a high Cg (cryocrit 5 - 10 p.c.) or very high Cg (cryocrit 10 p.c.) was found in a total of 13 patients: 1 patient from Group I, 3 from Group II, and 9 from Group III. Cryo positivity was found in 5 patients with F 1 - 2, in 13 with F 2 - 3, in 4 with F 3 - 4, and in 17 with F 4. Conclusions: Our findings confirmed the high prevalence of Cg in CHC patients in Lithuania, a clear association between Cg and the stage of fibrosis, teh higher prevalence of Cg in cirrhotic patients, and the occurrence of several typical extrahepatic manifestations. The impact of Cg on the course of chronic hepatitis C is not clearly understood; therefore, further studies are needed to clarify this issue.
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