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Tytuł oryginału: Requirements for the localization of p130 Cas to Z-lines in cardiac myocytes.
Autorzy: Kovacic-Milivojevic Branka, Damsky Caroline C., Gardner David G., Ilić Dusko
Źródło: Cell. Mol. Biol. Lett. 2002: 7 (2) s.323-329, il., bibliogr. 3 poz. - Międzynarodowa konferencja pt. Nauki przyrodnicze Gozd Martuljek 22-26.09. 2001 - Cz. 1 mater. konferencyjnych zamieszczono w nr 1/2002
Sygnatura GBL: 306,513

Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • in vitro

    Streszczenie angielskie: The vertebrate heart responds to hemodynamic load with the enlargement of postmitotic, terminally differentiated cardiac myocytes. Such hypertrophic changers are characterized by alternations in sarcomeric organization and gene expression. Previously, we estabilished a role for a nonreceptor tyrosine kinase, focal adhesion kinase, in signaling the changes in cytoskeletal organization associated with hypertrophy. Here, we report on data suporting a key role for p130Cas in this process,. In neonatal cardiac myocytes FAK, Cas and paxillin are located in sarcomeric Z-lines, suggesting that the Z-line is an important signaling locus in these cells. The expression of different Cas mutants results in a nearly complete loss of sarcomeric organization in these myocytes. Moreover, expression of the C-terminal focal adhesion-targeting domain of FAK both disrupted sarcomeric organization and interfered with the localization of endogenous Cas to Z-lines. These findings suggest that the association of FAK and Cas and the preservation of multiple protein-interaction motifs of Cas are required for the correct assembly of sarcomeres in cardiac myocytes.

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    Tytuł oryginału: Alteration of 99mTc-DMSA biodistribution in glomerulonephritis.
    Autorzy: Rajić Milena, Bogićević Momćilo, Antić Slobodan, Mitić Branka, Avramović Marina, Ilić Slobodan, Vlajković Marina, Mitić-Zlatković Marina, Stefanović Vladisav
    Źródło: Nucl. Med. Rev. 2002: 5 (1) s.15-19, il., tab., bibliogr. 26 poz.
    Sygnatura GBL: 313,603

    Hasła klasyfikacyjne GBL:
  • nefrologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • badanie porównawcze

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: The aim of this study was to assess the relation between 99mTc-DMSA biodistribution and its reliability as a marker of renal function in patients with glomerular kidney diseases. Material and methods: Sixty-seven patients involved in this study were classified into two group saccording to 99mTc-DTPA clearance and serum creatinine values: the 1st group consisted of 42 patients without renal failure while the 2nd group included 25 patients with renal failure. 99mTc-DMSA biodistribution was determined by measuring kidney, blood and urine activity at 2 h and 4 h. Results: The results, compared with those of 23 healhty volunteers, indicated the quantitative alteration of 99mTc-DMSA distribution in both glomerulonephritis patient groups. In reference to the control mean values of 2 h and 4 h, in patients without renal failure, kidney activity was found decreased to 52 p.c. and 57 p.c., while the blood activity increase of 37 p.c. and 44 p.c. was recorded together with the urine activity increase of 38 p.c. and 23 p.c. In patients with renal failure the alterations of renal and blood activity were more remarkable, but the urine loss was found to be unchanged. Conclusions: It is suggested that these biodistribution changes originate mainly from tubular impairment. However, in glomerulonephritis patients, altered glomerula filtration might considerably affect biodistribution of this radiopharmaceutical and limits its suitability for precise quantitative estimation of renal function.

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