Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL
Liczba odnalezionych rekordów:
Przejście do opcji zmiany formatu
Wyświetlenie wyników w wersji do druku
Prolongation of rat kidney graft survival after inoculation of allogeneic spleen cells: the effect of various routes of cell transfer.
Ann. Transplant. 2002: 7 (2) s.51-53, tab., bibliogr. 17 poz.
Hasła klasyfikacyjne GBL:
Objectives: It has been clearly demonstrated that after donor-specific cell transfer the prolongation of allograft survival can be obtained, but the problem of how to inoculate cells remains unresolved. In this study, the effect of either protal venous (PV) or systemic intravenous (IV) inoculations of rat donor-specific spleen cells on subsequent renal graft survival was evaluated. Methods: LEW recipients received 10**6 of spleen cells from allogeneic Fishcer or syngeneic donors 30 days before kidney transplantation by either PV or IV routes. Animals from the control group obtained buffered saline by the same routes. Results: Fischer grafts in nonimmunized LEW recipients were rejected after 9.6 ń 1.3 days. In contrast, the immunization of the recipients by the pretreatment with donor spleen cells prolonged renal allograft survival significantly (p 0.002). However, no difference in the graft survival was observed between animals ioculated with cells either by PV or by IV routes. In each studied group, long-time graft survival ( 100 days) was achieved in one case. Conclusions: These observations suggest that the effect of the various routes of allogeneic cell inoculations on subsequent organ graft survival time depends on the interval between the cell transfer and organ transplantation. Intravenous route seems to be as effective as PV route when transplantation is performed several days after donor-specific cell transfusion.
z abstraktem i deskryptorami