Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: HUG
Liczba odnalezionych rekordów: 3



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Tytuł oryginału: Caspases - their role in apoptosis and other physiological processes as revealed by knock-out studies.
Autorzy: Sadowski-Debbing Kenneth, Coy Johannes F., Mier Walter, Hug Hubert, Los Marek
Źródło: Arch. Immunol. Ther. Exp. 2002: 50 (1) s.19-34, il., tab., bibliogr. 113 poz.
Sygnatura GBL: 304,223

Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Caspases are crucial mediators of apoptosis, a form of physiological cell death. Their activation is carefully controlled by a philogenetically conserved death program, which is indispensable for the homeostasis and development of higher organisms. Dysregulation of apoptosis contributes to the pathogenesis of many human diseases. As effectors of the apoptotic machinery, caspases are considered potential therapeutic targets. In vitro studies have demonstrated the requirement of caspase activity for both the triggering phase as well as the execution of apoptosis, thus providing a molecular base for the fine-tuning of this process by pharmacological agents. The precise roles of the individual caspases in vivo and their functional relation to each other have been best demonstrated in genitically modified animals. The generation of single caspase-deficient mice have confirmed most of the data obtained in vitro and exposed some new aspects previously undetected in teh cell culture system. Interestingly, inactivation of many caspases revealed not only their expected participation in apoptotic as well as in the maturation of cytokines, but also provided hints about the role of at least some caspases in cell differentiation and stimulatory responses. In this review we will discuss what these studies have unveiled about the role of individual caspases in development, apoptosis, and inflammation, with particular focus on their role beyond the apoptotic process.

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    Tytuł oryginału: Effects of immunomodulators on acute Trypanosoma cruzi infection in mice.
    Autorzy: Oz Helieh S., Hughes Walter T., Thomas Elaine K., McClain Craig J.
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.BR208-BR211, il., tab., bibliogr. 14 poz.
    Sygnatura GBL: 313,278

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy

    Streszczenie angielskie: Patients who recover from acute trypanosomiasis may succumb to chronic Chagas' disease later in life due to age related immunosuppression, immune system disorders such as AIDS, or during periods of immunosuppressive therapy for organ transplantation. In this study, effects of immunomodultors with diverse properties were examined on the course of an acute and lethal Trypanosoma cruzi infection. ICR (Swiss) mice inoculated with Tulahuen (lethal) strain of T. cruzi were treated with 6 different immunomodulators and the course of infection was studied. Tacrolimus (FK-506) and dexamethasone increased parasitemia in mice when compared to infected untreated animals. Mycophenolate mofetil (RS-61443) ana recombinant interleukin-15 (IL-15) treatment decreased the number of parasites but had no effect on animal survival. In contrast, compound L-685-818 (tacrolius analog) and CD40 ligand (CD40L), provided protection against lethal infection. Mice that survived initial infection were all protected against reinfection. This study demonstrates the dangers of immunosuppression with tacrolimus and dexamethasone in T. cruzi infected subjects. While mycophenolate did not exacerbate the infection, our data suggest potential therapeutic applications for L-685-818 and CD40 ligand in trypanosomiasis.

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    Tytuł oryginału: 18 F-Fluorodeoxyglucose triple-headed coincidence detection imaging in oncology: preliminary results and comparison with dedicated PET.
    Autorzy: Winter Frederic De, Wiele Christophe Van de, Vandenberghe Stefaan, Vandenbossche Bieke, D'Asseler Yves, Huglo Damien, Dierckx Rudi
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.MT89-MT94, il., tab., bibliogr. 2 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Dual head coincidence (DHC) imaging has been proposed as a valuable and cheaper alternative to oncological PET. The increased sensitivity of the recently-developed triple-headed gamma camera (THC) optimized for coincidence detection has not been either validated or compared to the sensitivity of a dedicated PET system in a clinical study. Differences in contrast-to-noise-ratio (CNR) between dedicated FDG PET, DHC and THC imaging were assessed using a hot sphere phantom. Twenty-two oncological patients were prospectively studied with consecutive whole body FDG PET adn FDG THC imaging. The images were visually read by 2 experienced nuclear medicine specialists. The diagnostic sensitivity of FDG THC imaging was assessed using FDG PET as the imaging gold standard. Lesion size was determined using computed tomography or magnetic resonance imaging. The mean gain in CNR for THC as compared to DHC imaging was 35 p.c. (10 - 56 p.c.). Of 63 lesions, 58 (92 p.c.) on FDG PET were also detected wtih THC imaging. Considering only lesions smaller than 15 mm, the relative sensitivity was 86 p.c. (24.29). All lesions aboe 15 mm (n = 34) were detected using THC imaging. The first clinical results for THC imging are promising. The overall relative sensitivity in this limited series was 92 p.c. Only a few lesions smaller than 15 mm were missed.

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