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Tytuł oryginału: Pathogenesis of experimental toxoplasmosis in mice with strains differing in virulence.
Autorzy: Kodym Petr, Blażek Karel, Maly Marek, Hrda Stepanka
Źródło: Acta Parasitol. 2002: 47 (3) s.239-248, il., tab., bibliogr. s. 247-248
Sygnatura GBL: 303,018

Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • myszy
  • płeć żeńska

    Streszczenie angielskie: Parameters of virulence and the course of infection were compared in mice infected with Toxoplasma gondii strains P-Cz (mice virulent), 38 (cyst-forming, highly pathogenic) and HIF (cyst-forming, virulent). Mice, that succumbed to infection with cyst-forming strain 38 had lesions in the spleen (days 7-14 p.i.), liver (days 7-14 p.i.), lungs (days 9-21 p.i.), heart (days 14-21 p.i.), and brain (days 21-35 p.i.). In contrast, the animals which succumbed to strain P-Cz had practically unaffected hearts and brains. There were no fundamental differences in the temporal sequence of histopathological changes in infection with virulent and both cyst-forming strains. Depending on the virulence of each strain the infections differed markedly in the degree of organ damage, duration of parasitemia, numbers of cysts in the brain , as well as in mortality and body weight loss. The differencesin post mortem findings are not due to different organ affinity, but to the virulence-dependent time of death. All P-Cc infected mice die in the early stage of infection, before their hearts and brains can be seriously damaged.

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