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Tytuł oryginału:
NTPase/helicase of Flaviviridae: inhibitors and inhibition of the enzyme.
Autorzy:
Borowski
Peter,
Niebuhr
Andreas,
Schmitz
Herbert,
Hosmane
Ramachandra S.,
Bretner
Maria,
Siwecka
Maria A.,
Kulikowski
Tadeusz
Źródło:
Acta Bioch. Pol. 2002: 49 (3) s.597-614, il., tab., bibliogr. [82] poz.
Sygnatura GBL:
303,116
Hasła klasyfikacyjne GBL:
mikrobiologia
Typ dokumentu:
tytuł obcojęzyczny
Streszczenie angielskie:
RNA nucleoside triphosphatases (NTPase)/helicases represent a large family of proteins that are ubiquitously distributed over a wide range of organisms. The enzymes play essential role in cell development and differentiation, and some of them are invovled in transcription and replication of viral single-stranded RNA genomes. The enzymatic acitivities of a NTPase/helicase were also detected in the carboxyl-terminal non-structural protein 3 (NS3) of members of the Flaviviridae family. The crucial role of the enzyme for the virus life cycle was demonstrated in knock out experiments and by using NTPase/helicase specific inhibitors. This makes the enzyme and attractive target for development of FLaviviridae-specific antiviral therapies. This review will summarize our knowledge about the function and structure of the enzyme, eupdate the spectrum of inhibitors of the enzymatic activities of the NTPase/helicase anddescribe the different mechanisms by which the compouneds act. Some of the compounds reviewed herein could show potential utility as antiviral agents atgainst Flaviviridae viruses.
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