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Tytuł oryginału: NTPase/helicase of Flaviviridae: inhibitors and inhibition of the enzyme.
Autorzy: Borowski Peter, Niebuhr Andreas, Schmitz Herbert, Hosmane Ramachandra S., Bretner Maria, Siwecka Maria A., Kulikowski Tadeusz
Źródło: Acta Bioch. Pol. 2002: 49 (3) s.597-614, il., tab., bibliogr. [82] poz.
Sygnatura GBL: 303,116

Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Streszczenie angielskie: RNA nucleoside triphosphatases (NTPase)/helicases represent a large family of proteins that are ubiquitously distributed over a wide range of organisms. The enzymes play essential role in cell development and differentiation, and some of them are invovled in transcription and replication of viral single-stranded RNA genomes. The enzymatic acitivities of a NTPase/helicase were also detected in the carboxyl-terminal non-structural protein 3 (NS3) of members of the Flaviviridae family. The crucial role of the enzyme for the virus life cycle was demonstrated in knock out experiments and by using NTPase/helicase specific inhibitors. This makes the enzyme and attractive target for development of FLaviviridae-specific antiviral therapies. This review will summarize our knowledge about the function and structure of the enzyme, eupdate the spectrum of inhibitors of the enzymatic activities of the NTPase/helicase anddescribe the different mechanisms by which the compouneds act. Some of the compounds reviewed herein could show potential utility as antiviral agents atgainst Flaviviridae viruses.

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