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Tytuł oryginału: Apolipoproteins A-1 and B and the likelihood of non-fatal stroke and myocardial infarction - data from The Third National Health and Nutrition Examination Survey.
Autorzy: Qureshi Adnan I., Giles Wayne H., Croft Janet B., Guterman Lee R., Hopkins L. Nelson
Źródło: Med. Sci. Monitor 2002: 8 (5) s.CR311-CR316, tab., bibliogr. 31 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • kardiologia
  • neurologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • in vitro

    Streszczenie angielskie: The measurement of plasma apolipoproteins (APO) has been proposed for predicting the risk of cardiovascular diseases. However, the association between APOs and stroke is not well defined. We evaluated the association between plasma concentrations of APO A-1 and APO B with a physician diagnosis of stroke (n = 153), and electrocardiogram evidence or physician diagnosis of myocardial infarction (n = 379), in a nationally representative sample of 3,696 US adults aged ň 40 years who participated in the Third National Health and Nutrition Examiantion Survey. Multivariate logistic regression analyses were used to investigate these realtionships. After adjusting for differences in age, gender, race/ethnicity, education, hypertension, cholesterol, body mass index, and cigarette smoking, the upper quartile of APO A-1 (ň 161 mg/dl) when compared with the lowest quartile ( 126 mg/dl) was inversely associated with the likelihood of myocardial infarciton (Odds Ratio [OR], 0.6; 95 p.c. Confidence Interval [CI] 0.4 - 0.9) but not stroke. APO B concentrations were not associated with either myocardial infarction or stroke. However, an APO A-1 to B ratio ň 1.59 when compared wtih a ratio ó 1.04 was associated with a decreased likelihood of myocardial infarction (OR, 0.3; 95 p.c. Cl, 0.2 - 0.6); and stroke (OR 0.4, 95 p.c. Cl, 0.2 - 1.0). Higher APO A-1 concentrations were associate with a decreased likelihood for myocardial infarction but not for stroke. The APO A-1 to B ratio was inversely associated with both myocardial infarction and stroke and may be an important protective clinical marker for atherosclerosis.

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