Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: HELBIN
Liczba odnalezionych rekordów: 1



Przejście do opcji zmiany formatu | Wyświetlenie wyników w wersji do druku
1/1

Tytuł oryginału: Biomarkers of exposure and effect in an investigation of the influence of harmful occupational pollutants on the respiratory system mediated by the disturbances of antioxidant status of welders.
Autorzy: Kolarzyk Emilia, Stępniewski Marek, Pietrzycka Agata, Kitlinski Marek, Helbin Jadwiga, Zagrodzki Paweł
Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.307-315, il., tab., bibliogr. 20 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
Sygnatura GBL: 301,250

Hasła klasyfikacyjne GBL:
  • medycyna pracy
  • toksykologia
  • pulmonologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • praca epidemiologiczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.

    Streszczenie angielskie: A hypotehsis of existing cause-effect relationship between the disturbances of antioxidative balance, as a biomarker of occupational exposition to nitrogen oxides and ozone, concentration of selected trace elements in blood serum and hair, taken as biomarkers of exposition, and impairment of the respiratory system, regarded as a biomarker of effect has been tested on a representative goup of welders occupationally exposed to these pollutants. The subjects of the study were 94 welders aged 41.2 (+10.0) exposed in their workshops to nitric oxides and ozone in concentration exceeding TLV. As a control group served 115 workers, 40.8 (++10.2) years old, performing virtually the same tasks, except welding. It was found that in the group of welders concentrations of TAS, CT, SOD were lower compared to the controls. COPD and Small Airway Disease (SAD) in the welders groups was more frequent than in the controls (COPD:14.9 p.c. welders, 3.5 p.c controls; at risk of COPD 37.2 p.c. welders, 15.7 p.c controls; SAD:32 p.c. and 20 p.c respectively). From a wide array of trace elements in blood and their taken into account in principal components analysis (PCA), and mutual contributions analysis (MCA), only the relation of MEF50, Cu in blood serum and TAS were statistically valid. MCA revealed that asymmetrical interactions exist between TAS and Cu (ëCu-TAS = 97.2 p.c., ëTAS-Cu = 36.1), as well as between TAS and MEF50 (ëMEF50-TAS = 82.4 p.c., ëTAS-MEF50 = 23.9). The Concentration of copper in blood serum correlacted better with antioxidant status (TAS) than the content of this element in hair.

    stosując format: