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Hospitalizations among teachers in Denmark, 1981-1997.
Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.257-266, il., tab., bibliogr. 61 poz.
Hasła klasyfikacyjne GBL:
ll systems and organs of the body were statistically significant lower among teachers compared with other economically active people of Denmark.
It is a common notion that teachers constitute a group at high risk of occupational stress, but the potential health consequences of the assumed high stress levels are still poorly illuminated. The aim of the present study was to investigate morbidity among Danish teachers. Cohorts of Danish teachers of primary, secondary and vocational schools, aged 20-59 years in 1981, 1986, 1991 and 1994, were formed to calculate age standardized hospitalization ratios (SHRs) and time trends (1981-1997) for a large variety of diagnostic aggregations. Statistically significantly low SHRs for the major disease categories: neoplasms, diseases of the nervous, circulatory, respiratory, digestive and musculoskeletal systems were found both for man and women. We also found significantly low SHRs for the aggregated diagnostic group "injury and poisoning" in men and for diseases of the nervous and sense organs in women. Age standardized hospitalization rates with respect to diseases observed in practically all systems and organs of the body were statistically significantly lower among teachers compared with other economically active people of Denmark.
Results and follow-up of a phase III randomized study of recombinant human-granulocyte stimulating factor as support for immunosuppressive therapy in patients with severe aplastic anaemia.
Br. J. Haematol. 2002: 119 (4) s.1075-1082, il., tab., bibliogr. s. 1081-1082
Hasła klasyfikacyjne GBL:
praca opublikowana za granicą
dzieci 2-5 r.ż.
dzieci 6-12 r.ż.
dzieci 13-18 r.ż.
dorośli 19-44 r.ż.
dorośli 45-64 r.ż.
dorośli = 65 r.ż.
In patients with idiopathic severe aplastic anaemia who are treated with immunosuppressive agents to combat T lymphocyte-mediated destruction of haematopoietic progenitor cells, neutropenia is a major cause of infections and toxicity. Evidence from preliminary studies suggests that recombinant human glycosylated granulocyte colony-stimulating factor (lenograstim) increases the number and functionality of neutrophils in patients with severe aplastic anaemia. This randomized, parallel-group, multicentre study was conducted to evaluate the efficacy and safety of subcutaneous lenograstim during the first 12 weeks of standard immunosuppressive therapy in 102 patients with de novo severe aplastic anaemia. The addition of lenograstim to standard therapy resulted in an increase in the proportion of patients showing complete neutrophil response (83ú0 p.c. vs 44ú9 p.c.; P 0ú0001). This was seen even among patients with very severe aplastic anaemia (69ú2 p.c. vs 31ú6 p.c.; P = 0ú012). In patietns receiving lonograstim, median time to complete neutrophil response was shorter (6ú3 vs 16ú1 weeks; P = 0ú0001) and mean duration of first neutrophil response was longer (P = 0ú0248) than in the control group. At a median follow-up of 5 years, no difference was observed between the grous in term of survival, haematological response and occurrence of secondary leukaemia (one patient in each group). We conclude that lenograstim support of immunosuppressive therapy might be used for patients with severe aplastic anaemia as it significantly enhances neutrophil recovery but does not modify the overall response and survival.
The annexin-1 knockout mouse: what it tells us about the inflammatory response.
F. N. E.,
J. Physiol. Pharmacol. 2002: 53 (4) p. 1 s.541-553, il., tab., bibliogr. 85 poz.
Hasła klasyfikacyjne GBL:
The 37kDa protein annexin 1 (Anx-1; lipocortin 1) is a glucocorticoid-regulated protein that has been implicated in the regulation of phagocytosis, cell signalling and proliferation, and postilated to be a mediator of glucocorticoids action in inflammation and in the control of anterior pituitary hormone release. Immuno-neutralisation or antisense strtegies support this hypothesis as they can reverse the effect of glucocorticoids in several systems. We recently generated a line of mice lacking the Anx-1 gene noting that some tissues taken from such animals exhibited an increased expression of several proteins including COX-2 and cPLA2. In models of experimental inflammation, Anx-1 mice exhibit an exaggerated response and a partial or complete resistance to the anti-inflammatory effects leukocyte adhesion molecule expression, an increased spontaneous migratory behaviour of PMN in Anx-1 mice and a resistance in Anx-1 macrophages to glucocorticoid inhibition of superoxide generation. This paper reviews these and other data in the light of the development of the 'second messenger' hypothesis of glucocorticoid action.
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