Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: HAHN
Liczba odnalezionych rekordów: 7



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Tytuł oryginału: Oral cavity as a potential source of gastric reinfection by Helicobacter pylori.
Autorzy: Karczewska Elżbieta, Konturek Joanna E., Konturek Peter C., Cześnikiewicz Marta, Sito Edward, Bielański Władysław, Kwiecień Nina, Obtułowicz Wojciech, Ziemniak Witold, Majka Jolanta, Hahn Eckhart G., Konturek Stanisław J.
Źródło: Dig. Dis. Sci. 2002: 47 (5) s.978-986, il., tab., bibliogr. 24 poz.
Sygnatura GBL: 310,037

Hasła klasyfikacyjne GBL:
  • stomatologia
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Helicobacter pylori (Hp) is a common pathogen colonizing the a gastric mucosa, but some reports indicated that it may also be found in the oral cavity, which could serve as a reservoir of the bacteria and a source of gastric reinfection. Accordingly, we aimed to study whether the oral cavity, particularly gingival pockets, are colonized by Hp and whether it could be the source of gastric reinfection. We studied 329 patients with dyspeptic symptoms (257 with chronic gastritis, 15 with gastric ulcer. and 57 with duodenal ulcer). The [**13C]urea breath test (UBT), gastroscopy, and Hp culture from gastric biopsies were carried out, and material was collected from the oral cavity (gingival pocket) for bacteriological culture and genomic DNA studies. The serum was obtained for anti-Hp IgG and anti-CagA assays and saliva for anti-Hp IgA determination using the ELISA technique. bacteria in material from gingival pockets and biopsies from the corpus and antrum of stomach of 30 DU patients before and after Hp eradication were also examined by PCR technique, using primers specific for 16S rNA. All Hp-positive patients (276) were subjected to one week of triple therapy (omeprazole 2 x 20 mg twice a day, clarithromycin 2 = 500 mg twice a day, and metronidazole 2 x 500 mg twice a day). The measurements descrived above were then repeated at four weeks and six months. Bacterkilogical culture showed the prsence of Hp in the material from oral cavity in about 50 p.c. of patients, whereas UBT, used as a gold standard, revealed gastric Hp infection in about 84 p.c. of these patients...


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    Tytuł oryginału: Functional and clinical characterization of KCNJ2 mutations associated with LQT7 (Andersen syndrome).
    Autorzy: Tristani-Firouzi Martin, Jensen Judy L., Donaldson Matthew R., Sansone Valeria, Meola Giovanni, Hahn Angelika, Bendahhou Said, Kwieciński Hubert, Fidziańska Anna, Plaster Nikki, Fu Ying-Hui, Ptacek Louis J., Tawil Rabi
    Źródło: J. Clin. Invest. 2002: 110 (3) s.381-388, il., tab., bibliogr. 38 poz.
    Sygnatura GBL: 310,487

    Hasła klasyfikacyjne GBL:
  • pediatria
  • genetyka
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.

    Streszczenie angielskie: Andersen syndrome (AS) is a rare, inherited disorder characterized by periodic paralysis, long QT (LQT) with ventricular arrhythmias, and skeletal developmental abnormalitise. We recently established that AS is caused by mutations in KCNJ2, which encodes the inward rectifier K+ channel Kir2.1. In this report, we characterized the functional consequences of three novel and seven previously described KCNJ2 mutations using a two-microelectrode voltage-clamp technique and correlated the findings with the clinical phenotype. All mutations resulted in loss of function and dominant-negative suppression of Kir2.1 channel function. In mutation carriers, the frequency of periodick paralysis was 64 p.c. and dysmorphic features 78 p.c. LQT was the primary cardiac manifestation, present in 71 p.c. of KCNJ2 mutation carriers, with ventricular arrhythmias present in 64 p.c. While arrhythmias were common, none of our subjects suffered sudden cardiac death. To gain insight into the mechanismof arrhythmia susceptibility, we simulated the effect of reducdd Kir2.1 using a ventricular myocyte model. A reduction in Kir2.1 prolonged the termkinal phase of the cardiac action potential, and n the setting of reduced extracellular K+, nduced Na+/Ca2+ exchanger-dependent delayed afterdepolarizations and spontaneous arrhythmias. These findings suggest that the substrate for arrhythmia susceptibility in AS is distinct from the other forms of inherited LQT syndrome.


    3/7

    Tytuł oryginału: Effect of Helicobacter pylori on delay in ulcer healing induced by aspirin in rats.
    Autorzy: Konturek Peter C., Brzozowski Tomasz, Kwiecień Sławomir, Drozdowicz Danuta, Harsch Igor A., Meixner Holger, Stachura Jerzy, Hahn Eckhart G., Konturek Stanisław J.
    Źródło: Eur. J. Pharmacol. 2002: 451 (2) s.191-202, il., tab., bibliogr [37] poz.
    Sygnatura GBL: 312,088

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • mikrobiologia
  • gastroenterologia

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Helicobacter pylori and nonsteroidal anti-inflammatory drugs (NSAIDs) are major pathogenic factors in peptic ulcer disease but whether these two factors exert synergistic or antagonistic effects on ulcer healing has been a subject of controversy. We compared the effect of aspirin alonne with that of aspirin combined with H. pylori on gastric acid secretion and healing of acetic gastric ulcers in rats. The H. pylori colonization of gastric mucosa was determined by viable H. pylori culture, histology and assessment of bacterial DNA using polymerase chain reaction (PCR). The area of ulcers, gastric blood flow, mucosal generation of prostaglandin E2 and plasma gastrin levels and expression of cyclooxygenase-1, cyclooxygenase-2 and growth factors was determined. Aspirin delayed significantly the healing of chronic gastric ulcers, decreased the gastric blood flow at the ulcer margin and gastric mucosal prostaglandin E2 heneration being without significant influence on gastric acid output H. pylori acquisition that produced moderate gastric inflammation at the ulcer margin delayed significantly the healing of gastric ulcers, decreased significantly both the gastric blood flow at the ulcer margin and the gastric secretion while raising significantly the gastric mucosal prostaglandin E2 generation and plasma gastrin levels. H. pylori infection attenuated the aspirin-induced inhibition of ulcer healing and accompanying fall in the gastric blood flow. Both aspirin and H. pylori up-regulated significantly cyclooxygenase-2 messenger RNA (mRNA)...


    4/7

    Tytuł oryginału: Progastrin and cyclooxygenase-2 in colorectal cancer.
    Autorzy: Konturek Peter C., Bielański Władysław, Konturek Stanisław J., Hartwich Artur, Pierzchalski Piotr, Gonciarz Maciej, Marlicz Krzysztof, Starzyńska Teresa, Zuchowicz Monika, Darasz Zbigniew, G”tze Jens P., Rehfeld Jens F., Hahn Eckhart G.
    Źródło: Dig. Dis. Sci. 2002: 47 (9) s.1984-1991, il., tab., bibliogr. 41 poz.
    Sygnatura GBL: 310,037

    Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Colorectal cancers (CRCs) are one of the most common forms of cancer in Poland and one of the leading causes of dearh. The tumors have been attributed to genetic, dietary, and other environmemtal factors, but recently factors such as gastrin have also been implicated in the carcinogenesis. The relationship between plasma amidated and nonamidated gastrin in CRCs is controversial. This study was designed to determine the plasma levels of progastrin and amidated gastrin in 50 CRC patients before and 3-6 months after removal of the tumor, to determine the tumor concentrations of these gastrin peptides and the level of expression for gastrin mRNA and gastrin/CCKb receptor mRNA, to examine the expression of cyclooxygenase COX-1 and COX-2 in mRNA in CRC tissue, and to compare the prevalence of Hp and its cytotoxic protein, CagA, and cytokines (TNFŕ, IL-1á, and IL-8) in CRCs, before and after removal of tumor. It was found that thwe CRC, its resection margin, and the plasma contained severalfold higher levels of progastrin than of amidated gastrins and that the removal of the CRC tumor resulted in a marked reduction in plasma progastrin level without a significant alteration in plasma levels of amidated gastrins. Both gastrin and CCKb-R mRNA were detected in the cancer tissue and resection margin by RT-PCR, and similary, COX-1 and COX-2 mRNA were expressed in these tissues of moast CRCs. The seroprevalence of Hp, especially that expressing CagA, and levels of IL-1á, but not other cytokines, were significantly higher in CRC patients than in 100 age-...


    5/7

    Tytuł oryginału: Wireless capsule endoscopy - beyond the frontiers of flexible gastrointestinal endoscopy.
    Autorzy: Rabenstein Thomas, Krauss Norbert, Hahn Eckhart G., Konturek Peter
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.RA128-RA132, il., bibliogr. 32 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • zwierzęta
  • psy

    Streszczenie angielskie: Wireless capsule endoscopy is currently the outstanding technical innovation in diagnostic gastrointestinal endoscopy. Especially for small bowel diseases this new technique offers several potential advantages compared to traditional diagnostic tools. Capsule endoscopy is a painless procedure that can be performed as an ambulatory endoscopic examination. First experimental studies proved the good tolerance of the capsule endoscopy ad the possibility of a complete visual investigation of the small bowel. Clinical studies demonstrated possible fields of application: Obscure chronic or intermittent gastrointestinal blood loss and inflammatory bowel disease. The major risk of the procedure - intestinal obstruction by the capsule - may hinder its use in the diagnosis of polyps or tumors in the small bowel. In the next years it will be exciting to see whether capsule endoscopy will finally reach the clinical significance we expect at the moment. Possibly, the diagnostic algorithm for obscure gastrointestinal bleeding has to be changed in the future due to the abandonment of less effective procedures.


    6/7

    Tytuł oryginału: Cat-scratch disease in an immunocompromised host.
    Autorzy: Harsch Igor Alexander, Schahin Simin Pour, Schmelzer Alexander, Hahn Eckhart Georg, Konturek Peter Christopher
    Źródło: Med. Sci. Monitor 2002: 8 (3) s.CS26-CS29, il., bibliogr. 20 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • immunologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Background: Themain causative agents of cat-scratch disease are Bartonella henselae, tiny, gram-negative bacilli. The disease usually has a benign course with the development of a papule at the inoculation site, followed by regional lymphadenopathy. In most cases, complete resolution occurs, but in immunocompromised hosts, the course of the disease can be aggravated. Case report: A patietn recieved methotrexate and corticosteroids for 3 months due to rheumatoid arthritis. He developed fever, exanthema and leukopenia under methotrexate therapy. Dark red indurations with central ulcerations at his right thigh revealed a further problem apart from the methotrexate-induced leucopenia and immunosuppression. The ulcerations were the remainders of recurrent scratches from the patient's cat. The patient's antibody titers against Bartonella henselae remained low and inguinal lymph node swelling was only for a short time to be observed, this reaction obviously weakened as a result of the immunosuppression. However, the typical course, the exclusion of other reasons for the exanthema and the rapid improvement of the patient's condition after antibiotic treatment ascertained the diagnosis. Conclusions: In immunocompromised hosts, diseases with a typically benign course can become severe and life-threatening illnesses. Ownership of pets should be taken into consideration before onset of an immunosuppressive therapy.


    7/7

    Tytuł oryginału: Magnetic resonance imaging of the heart.
    Tytuł polski: Obrazowanie serca metodą rezonansu magnetycznego.
    Autorzy: Sandstede J”rn J. W., Beer Meinrad, Pabst Thomas, K”stler Herbert, Kenn Werner, Neubauer Stefan, Hahn Dietbert
    Źródło: Prz. Lek. 2002: 59 (8) s.595-600, il., bibliogr. 38 poz.
    Sygnatura GBL: 310,563

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • radiologia

    Typ dokumentu:
  • praca przeglądowa
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

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