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Zapytanie: GUMIENICZEK
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Tytuł oryginału: Changes in antioxidant status of heart muscle tissue in experimental diabetes in rabbits.
Autorzy: Gumieniczek Anna, Hopkała Hanna, Wójtowicz Zbigniew, Nikołajuk Justyna
Źródło: Acta Bioch. Pol. 2002: 49 (2) s.529-535, tab., bibliogr. s. 534-535
Sygnatura GBL: 303,116

Hasła klasyfikacyjne GBL:
  • endokrynologia
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • króliki
  • płeć męska
  • zwierzęta

    Streszczenie angielskie: The present study was designed to evaluate the oxidative stress-related parameters in alloxan-induced diabetes in rabbits. After 3, 6, 12 and 24 weeks of hyperglycaemia the enzymatic and non-enzymatic factors were measured in heart tissue fo diabetic and control groups. Superoxide dismutase and glutathione peroxidase activities and the contents of total sulfhydryl compounds signficantly increased at all time intervals. Catalase activity increased initially (after 3 and 6 weeks), decreased after 12 weeks and increased again at the 24th week of the experiment. Glutathione reductase activity increased initially (at 3rd week), decreased below control level after 6 and 12 weeks, then increased again. Ascorbic acid concentration decreased after 3 and 6 weeks, and increased at the 12th and 24th weeks. The level of lipid peroxidation products was reduced after 3, 6 and 12 weeks of the experiment. After 24 weeks it was significantly elevated. These data suggest that hyperglycaemia induces oxidative stress in the heart but the defense mechanisms in the heart tissue are fairly efficacious against oxidative injury.

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