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Zapytanie: GREGORASZCZUK
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Tytuł oryginału: Cyproterone, norethindrone, medroxyprogesterone and levonorgestrel are less potent local human growth hormone and insulin-like growth factor I secretion stimulators than progesterone in human breast cancer explants expressing the estrogen receptor.
Autorzy: Milewicz T., Kołodziejczyk J., Krzysiek J., Basta A., Sztefko K., Kurek S., Stachura J., Gregoraszczuk E. L.
Źródło: Gynecol. Endocrinol. 2002: 16 (4) s.319-329, il., bibliogr. 57 poz.
Sygnatura GBL: 313,072

Hasła klasyfikacyjne GBL:
  • endokrynologia
  • ginekologia i położnictwo
  • onkologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska
  • in vitro

    Streszczenie angielskie: The aim of the present study was to compare the ability of natural progesterone and synthetic progestins to stimulate local growth hormone (GH) and insulin-like growth factor I (IGF-I) secretion by breast cancer explants. Explants obtained during surgery were divided according to their estrogen/progesterone receptor phenotype - ER(+)PR(-); ER(+)PR(+); ER(-)PR(+) - as determined by immunocytochemistry. Natural progesterone (10**-5 mol/l) and synthetic progestins (cyproterone acetate (5 x 10**-7 mol/l), norethindrone (10**-5 mol/l), medroxyprogesterone acetate (10**-7 mol/l), and levonorgestrel (10**-7 mol/l) were tested in vitro for their ability to induce secretion of proliferation-promoting agents such as human GH (hGH) and IGF-I. All hormone-dependent breast cancer cell types responded to progesterone stimulation with increased local hGH secretion, while in the non-malignant tissue this effect was observed only in PR(+) cells. Moreover, progesterone in only PR(+) cells in vitro stimulated local IGF-I secretion by both malignant and non-malignant tissue. Medroxyprogesterone and levonorgestrel increased GH secretion by both malignant and non-malignant ER(-)PR(+) breast cancer explants, while cypropterone stimulated it only in non-malignant tissue. None of the synthetic progestins tested in this experiment exerted an effect on GH secretion by both malignant and non-malignant tissue of ER(+) breast cancer explants. The present data additionally showed that, apart from cyproterone, which increased IGF-1 secretion in the same manner as progesterone by both malignant and non-malignant ER(-)PR(+) breast explants...

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