Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: GRALEWICZ
Liczba odnalezionych rekordów: 5



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1/5

Tytuł oryginału: Małe napady padaczkowe u szczura laboratoryjnego, czyli o czym eksperymentator pamiętać powinien.
Tytuł angielski: Spontaneous petit mal-like epileptic seizures in the laboratory rat: an issue that the experimenter should be aware of.
Autorzy: Gralewicz Sławomir
Źródło: Post. Hig. 2002: 56 (3) s.341-351, il., bibliogr. [29] poz., sum. - Konferencja pt. Blaski i cienie elektrofizjologii mózgu in vitroKonferencja pt. Techniki elektrofizjologiczne w badaniach zjawisk bioelektrycznych - od kanałów jonowych po sieci neuronalne KrakówŁódź 24.10.07-08.06. 20012002
Sygnatura GBL: 301,727

Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca związana ze zjazdem

    Wskaźnik treści:
  • zwierzęta

    Streszczenie angielskie: A certain proportion of laboratory rats of various strains is characterized with a heritable, abnormally high propensity for spontaneous, nonconvulsive electrocortical seizures. The seizures have from of bursts of spike-wave discharges (SWD) reminiscent of the human petit-mal epilepsy. The experimenter is usually unaware of this fact. The paper concerns the question of reliability of results obtained on rats samples derived from populations nonhomogenous with respect to the high propensity for SWD seizures.


    2/5

    Tytuł oryginału: Behavioural responsiveness to amphetamine or scopolamine following repeated exposure to chlorphenvinphos in rats.
    Autorzy: Gralewicz Sławomir, Lutz Piotr, Tomas Tadeusz
    Źródło: Acta Neurobiol. Exp. 2002: 62 (2) s.75-83, il., tab., bibliogr. [24] poz.
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: A number of reports indicate that exposure to organophosphates (OPs), inhibitors of acetylcholinesterase (AChE), may result in long-lasting neurobehavioural alterations suggestive of an increased cholinergic tone. It is known that rats with cholinergic hyperreactivity are behaviourally hyposensitive to cholinergic antagonists and dopaminergic agonists. The purpose of the present study was to find out whether a similar trait would develop in rats exposed to chlorphenivinphows (CVP), an OP pesticide, in the past. The rats wre given ten daily i.p. injections of CVP at doses of 0.5 mg/kg (group P-0.5) or 1.0 mg/kg (group P-1.0). The locomotion stimulating effect of i.p. injection of 1.0 mg/kg amphetamine (AMPH), or 0.6 mg/kg scopolamine (SCOP), was assessed on postexposure day 21 (group P-0.5) or 42 (group P-1.0), i.e. after a time suffcient for AChE recovery. The assessment revealed that in gorup P-1.0 the behavioural response to AMPH and SCOP was significantly depressed. In rats of the P-0.5 group, however, the behavioural response to each of the frugs was increased. The results suggest that, depending on the exposure level, contrasting alterations in some neurotransmitter systems may be induced by repeated exposure to CVP.


    3/5

    Tytuł oryginału: Behavioral sensitization to amphetamine induced by a single i.p. dose of oxotremorine in the rat.
    Autorzy: Gralewicz Sławomir
    Źródło: Acta Neurobiol. Exp. 2002: 62 (2) s.93-98, il., bibliogr. s. 97-98
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Earlier experiments have revealed that rats treated with a single dose of chlorphenvinphos (CVP), an irreversible acetylchlinesterase inhibitor, are hyposensitive to amphetamine (AMPH) given three weeks after CVP. Exposure to CVP results in an excess of acetylcholine with subsequent overactivation of the nicotinic as well as muscarinic cholinergic receptors. The purpose of the present experiment was to find out whether a selective activation of muscarinic receptors could induce behavioral hyposensitivity to AMPH. To attain this purpose, male rats were pretreated once with 0.00, 0.135, 0.27 or 0.55 mg/kg of oxotremorine, a muscarinic agonist, and challenged 15 days later with 1.0 mg/kg dose of AMPH. The pre- and postinjection open-field behavior of the rats was tested with the use of a computerized set of activity meters. The testing revealed that in oxotremorine pretreated animals the behvioral response, to AMPH, i.e. increase in the ambulatory activity, was not diminished but, to the contrary, it was augmented. This effect was dose-dependent, being most pronounced in rats given the 0.55 mg/kg of oxotremorine. The possible cause of the difference between the effect of CVP and oxotremorine is discussed.


    4/5

    Tytuł oryginału: Behavioral sensitivity to amphetamine after repeated exposure to an organophosphorous pesticide in the rat. Effect of coexposure to restraint.
    Autorzy: Gralewicz Sławomir, Wiaderna Dorota, Lutz Piotr
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (3) s.229-238, il., tab., bibliogr. 30 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: In the work environment, chemical stressors coexists frequently with physical or psychological stressors. The purpose of the present experiment was to find out whether the effects of a repeated exposure to chlorphenvinphos (CVP), an organophosphorus pesticide, could be modified by a concurrent exposure to restraint, a psychological stressor. The experiment was performed on male Wistar rats. CVP was administered ten times (one injection/day) at doses of 0.5 or 1.0 mg/kg i.p. (1/20 and 1/10 of LD50, respectively) within a period of two weeks. A half of the rats from each group were immobilized in restraint chambers for 120 min/day starting 10-15 min after CVP injection. In each rat, the effect of 0.5 mg/kg of amphetamine (AMPH) and 0.75 mg/kg of scopolamine (SCOP) on motor activity in an open-field was tested three weeks or six weeks (in rats exposed to 0.5 mg/kg or 1.0 mg/kg doses of CVP, respectively) after the last exposure day. No clear cut effect on the behavioral responsiveness to AMPH or SCOP were noted in rats subjected to repeated restraint, repeated 0.5 mg/kg doses of CVP, or combination of these two stressors. In rats exposed to CVP at the 1.0 mg/kg doses, the behawioral response to AMPH was augmented and this effect was not apparently altered in rats coexposed to restraint. The above result indicates that the repeated exposure to CVP may lead to functional alterations within the central nervous system and that coexposure to restraint neither facilitates nor prevents these alterations from development.


    5/5

    Tytuł oryginału: Assessment of long-term neurotoxic effects of exposure to mesitylene (1,3,5-trimethylbenzene) based on the analysis of selected behavioral responses.
    Autorzy: Wiaderna Dorota, Gralewicz Sławomir, Tomas Tadeusz
    Źródło: Int. J. Occup. Med. Environ. Health 2002: 15 (4) s.385-392, il., bibliogr. 21 poz.
    Sygnatura GBL: 306,313

    Hasła klasyfikacyjne GBL:
  • toksykologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Trimetylbenzene isomers: pseudocumene, hemimellitene and mesitylene, are major components of numerous commercial solvents and high-grade fuels. In our earlier research on rats we have proved that inhalation exposure to pseudocumene of hemimellitene at concentrations close to the MAC value resutls in behavioral changes detectable many weeks after cessation of the exposure. The aim of our present study is to determine whether exposure to mesitylene causes effects similar to those observed for pseudocumene and hemimellitene. Male rats were used in the experiment. The animals were exposed in the inhalation chambers to mesitylene vapors at the following concentrations: 0 ppm - group MESO; 25 ppm (125 mg/m3) - group MES25; 100 ppm (500 mg/m3) - group MES100 and 250 ppm (1250 mg/m3) - gropu MES250 for 4 weeks (6 h/day, 5 days/week). The following behaviors were tested: 1) ability to find water in a radial maze (14-19 days after the exposure); 2) open field locomotor activity (25 days after the exposure); 3) acquiring the conditioned reaction of active avoidance (35-45 days after the exposure); 4) sensitivity to pain and stress-induced changes of pain sensitivity (50-51 days after the exposure); and 5) acquiring the conditioned reaction of two-way active avoidance (54-60 days after the exposure). Significant between-group differences were noted in passive and active avoidance tests and sensitivity to pain. In the Mes25, MES100 and MES250 rats, the persistence of the passive avoidance reaction was shorter, and more trials were required to produce the active avoidance reaction than in controls (group MESO), the MES100 group appeared to be more fearful on the second day of testing on the hot plate...

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