Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: GRADOŃ
Liczba odnalezionych rekordów: 3



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Tytuł oryginału: A multicentre randomized/controlled trial of a conventional versus modestly accelerated radiotherapy in the laryngeal cancer: influence of a 1 week shortening overall time.
Autorzy: Hliniak A., Gwiazdowska B., Szutkowski Z., Kraszewska E., Kukolowicz P., Jarząbski A., Sochacka B., Mazurkiewicz M., Paprota K., Oliskiewicz W., Zadrożna O., Milecki P., Kubiak M., Czopkiewicz L., Jagas M., Góźdź S., Wieczorek A., Woytowicz A., Cisowska B., Magdziarz H., Nowakowski S., Kośniewski W., Laskosz I., Serafin A., Gradoń E.
Źródło: Radiother. Oncol. 2002: 62 (1) s.1-10, il., tab., bibliogr. 13 poz.
Sygnatura GBL: 312,846

Hasła klasyfikacyjne GBL:
  • onkologia
  • otorynolaryngologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background and purpose: To compare in a phase III study the loco-regional control, disease-free survival and overall survival induced by an accelerated regimen (AF) as compared with conventional regimen (CF) and to analyze the early and late post-radiation morbidity in both arms. Materials and methods: Patietns with ó 75, WHO 0-1, suitable for a radical course of radiotherapy T1-T3, NO, MO, stage of glottic and supraglottic laryngeal cancer were randomized to either CF: 66Gy given in 33 fractions over 45 days or AF: 66Gy given in 33 fractions over 38 days (2 fractions every Thrusday). A total of 395 patients were included from 05.1995 to 12.1998. Results. Early toxicity: At the end of radiotherapy patietns treated with AF complained for more severe reactions than patients treated with CF. In 8 weeks after treatment completion patients treated with AF complained only for more severe pain on swallowing (P = 0.027). In 4 months after treatment completion all types of toxicity except for skin teleangiectasia (P = 0.001) were similar in the two groups. Locoregional control: comparison between CF and AF showed no difference in terms of loco-regional control (P = 0.37). Conclusions: The improvement in AF in terms of loco-regional control is estimated to be 3-5 p.c. in comparison with conventional regimen and is not significant. The intensity of reactions after 4 months was similar in both arms, what suggests the possibility of further shortening of the overall time by few days or enhancing the total dose within the limits of acceptable morbidity.

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    Tytuł oryginału: Badania rozkładów wielkości cząstek aerozolowych acetonidu triamcinolonu.
    Tytuł angielski: Evaluation of aerosol characteristics of triamcinolone acetonide.
    Autorzy: Pirożyński Michał, Gradoń Leon, Sosnowski Tomasz R.
    Źródło: Ter. Leki 2002: 52 (4) s.38-42, il., bibliogr. 16 poz., sum.
    Sygnatura GBL: 313,514

    Hasła klasyfikacyjne GBL:
  • farmacja

    Streszczenie angielskie: Steroids given in inhalation are the crucial part of therapy in asthma and COPD. In both entities the pathological changes start in the small airways. The aim of the inhalation therapy should be delivery of the drug particles to the smallest airways. The biggest drawback of pMDI drug delivery is the need of synchronization of inhalation and aerosol generation. It is estimated that 75 p.c. of the patients cannot perform a proper aerosol inhalation with the pMDI device. One of the methods improving the deposition of aerosols from pMDI is the introduction of spacers. In steroid therapy introduction of spacer not only improved aerosol delivery but also reduced the side effects of local irritation, systemic and local effects of improper inhalation. The aim of the study was to analyze the aerosol characteristics of the generated aerosol of triamcinolone acetonide (Azmacort) from a pMDI device and to assess the effect of a integrated spacer supplied with the pMDI device on the aerosol characteristics. The results of our analysis showed that small particles (ó 0,5 ćm) made up 70 p.c. of the mass of the particles generated in one puff. The integrated spacer also increased the small particle fraction (0,5 - 1 ćm) in the studies aerosol. Larger particles (1 - 5 ćm, 5 - 10 ćm) made up only a small mass of the generated aerosol. The characteristics of the generated aerosol showed that it is suitable for treatment of lower airways inflammatory disorders seen in asthma and COPD. Small fractions of larger particles reduced the possibility of local and systemic side effects of triamcinolone.

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    Tytuł oryginału: Wpływ nowych nośników niefreonowych na rozkład cząstek aerozolowych preparatów Berodual N i Berotec N.
    Tytuł angielski: Effect of non-freon propellants on aerosol characteristics of Berodual N and Berotec N.
    Autorzy: Pierożyński Michał, Sosnowski Tomasz, Gradoń Leon
    Źródło: Ter. Leki 2002: 52 (5/6) s.53-57, il., tab., bibliogr. 12 poz., sum.
    Sygnatura GBL: 313,514

    Hasła klasyfikacyjne GBL:
  • farmacja

    Streszczenie angielskie: Inhalation therapy is the mainstem therapy of respiratory disorders. The most often used aerosol generator remains the pMDI device. Due to implication of the Montreal Protocol and ban of freon propellants a complete change of the presently used aerosols is mandatory. Change of propellants will effect the characteristics of the generated aerosols. The change of the drugs may also effect the deposition patterns of the new foermulations. The aim of the study was to amylase the effect of introducing HFA 134a as the non-CFC propellant in the two most popular aerosol preparation Berodual N and Berotec N. We have shown that the new propellant HFA 134a improved the deposition propertioes of both drugs. An increase of the small particle fraction was seen in both, leading to a better deposition in the peripheral airways so valuable in COPD patients and asthmatics.

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