Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: GOLDSTEIN
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Tytuł oryginału: Efficacy and safety of doxofylline compared to theophylline in chronic reversible asthma - a double-blind randomized placebo-controlled multicentre clinical trial.
Autorzy: Goldstein Marc F., Chervinsky Paul
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR297-CR304, il., tab., bibliogr. 27 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • immunologia
  • farmacja
  • pulmonologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Background: Experimental studies have shown that doxofylline is endowed with a remarkable bronchodilator activity with less extra-respiratory effects than theophylline. This trail was designed to compare the efficacy and safety of doxofylline, theophylline, and placebo in patients with chronic reversible bronchial asthma. Material/Methods: Three hundred forty-six patietns were randomly assigned to a 12-week oral treatment with either doxofylline 400 mg t.i.d. (high dose), doxofylline 200 mg t.i.d. (low dose), theophylline 250 mg t.i.d. (active control) or placebo. Pulmonary function tests (PFTs) were performed biweekly. Patients kept records of peak flow meter (PFM) measurements, asthma attack rate and beta-2-agonist use (albuterol). Results: Changes in FEV1 2 hours after the administration of treatments versus baseline exhibited statistically significant differences between doxofylline 400 mg t.i.d. and placebo and between theophylline and placebo. Similar differences were monitored on the other variables (FVC, PFER, FEF25-75 p.c. Asthma attack rate and use of albuterol decreased remarkably with doxofylline 400 mg t.i.d. and theophylline. There were few statistically significant differences between doxofylline 200 mg t.i.d. and placebo. Significantly more patients had to interrupt treatment because of adverse events under theophylline than under doxofylline 400 mg t.i.d. (p=0.001). With doxofylline 400 mg t.i.d., the number of patietns treated to spare one dropout due to theophylline was 5. Conslusion: This study provides evidence that doxofylline 400 mg t.i.d. is an effective treatment for relieving airway obstruction and displays a better safety profile with respect to theophylline 250 mg t.i.d. with a favorable risk-to-benefit ratio.


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    Tytuł oryginału: Cor triatriatum sinistrum in children. A congenital cardiac anomaly which is difficult to diagnose.
    Tytuł polski: Lewostronne serce trójprzedsionkowe u dzieci. Wrodzona wada serca trudna diagnostycznie.
    Autorzy: Żyła-Frycz Maria, Baranowska Anna, Białkowski Jacek, Szkutnik Małgorzata, Goldstein Lili, Moll Jacek, Wojtalik Michał, Skalski Janusz, Zembala Marian
    Źródło: Kardiol. Pol. 2002: 57 (7) s.30-36, il., tab., bibliogr. 17 poz. - Tekst równol. w jęz. pol.
    Sygnatura GBL: 313,397

    Hasła klasyfikacyjne GBL:
  • kardiologia
  • radiologia
  • pediatria

    Typ dokumentu:
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • niemowlęta
  • dzieci 2-5 r.ż.
  • dzieci 6-12 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background. Cor triatriatum (CT) is a rare congenital cardiac anomaly which is difficult to diagnose. Aim. To present study group consisted of 15 patients (mean age 3,4 years, range 0.25-12 years) with CT in whom the results of clinical findings. ECG, chest radiography and echocardiography were analysed. Five patients underwent cardiac catheterisation. Results. Clinical symptoms and ECG as well as radiographic findings were non-specific. The final diagnosis was established based on echocardiographic examination. In all children CT was diagnosed; in addition, there patients had coexisting congenital anomaly such as ventricular septal defect, pulmonary stenosis or atrio-ventricular septal defect. The results of cardiac catheterisation did not change the diagnosis established by echocardiography. Fourteen patients underwent surgical correction. In three patients the intra-operative findings differed slightly from those obtained during echocardiography : in one patient the presence of total anomalous pulmonary venous connection with the right atrium was not confirmed, whereas in the other two patients an additional left superior vena cava connected with the left atrium was found. Two children died in the early post-operative period: one due to low cardiac output syndrome and the second due to central nervous disorder. Conclusions. CT is a congenital cardiac anomaly which may require early surgical intervention. Echocardiography with the use of Doppler technique is the best disagnostic method. During echocardiographic examination, special attention should be paid to venous drainage to the atria.

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