Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: GOLAN
Liczba odnalezionych rekordów: 3



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Tytuł oryginału: In vitro cytostatic activity of 8-substituted and tricyclic analogues of acyclovir.
Autorzy: Hładoń Bogusław, Gośliński Tomasz, Laskowska Halina, Baranowski Daniel, Ostrowski Tomasz, Zeidler Joanna, Ruszkowski Piotr, Golankiewicz Bożenna
Źródło: Pol. J. Pharmacol. 2002: 54 (1) s.45-53, il., tab., bibliogr. 22 poz.
Sygnatura GBL: 313,156

Hasła klasyfikacyjne GBL:
  • farmacja
  • onkologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • in vitro

    Streszczenie angielskie: Out of a series of twenty 8-substituted or/and 1,N-2-bridged (tricyclic) derivatives of acyclovir (a selective antiherpetic drug), known to be nontoxic to normal cells, seven compounds were found to exhibit moderate cytostatic activity in KB human tumor tissue culture system with ED50 activity values ranging from 0.052-0.094 x 10**-3 mole/l. The structure-activity relationship analysis indicated that the primary factors determining their cytotoxicity were: 1) bromine atom at the C-8 position of the bicyclic derivatives and 2) unsubstituted appended ring in the tricyclic derivatives. Combination of two structural elements carrying the cytotoxicity gave diverse effects, enhancement or decrease in activity depending on particular cases. Two compounds (of four selected), 8-bromoacyclovir and 1,N-2-ethenoacyclovir, having unsubstituted 9-[(2-hydroxyethoxy)methyl] chain, showed approximately 2-fold increase in their cytotoxicity against HeLa tumor cells in the presence of the induced microsomal generating system suggesting that their cytooxicity depends on the drug metabolic transformation into their active metabolites (intermediates) via MFO-system, and that structural unit of this chain is essential for abovementioned activation. Presently found remarkable cytotoxic selectivity of acyclovir analogues against KB and HeLa tumor cells together with previously reported in the literature specific cytotoxic activity of acyclovir against murine leukemia L1210 cells seem to be encouraging for further investigation of this class of compounds in other tumor systems.


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    Tytuł oryginału: Morphometric parameters of the human pineal gland in relation to age, body weight and height.
    Autorzy: Golan Janusz, Torres Kamil, Staśkiewicz Grzegorz J., Opielak Grzegorz, Maciejewski Ryszard
    Źródło: Folia Morphol. 2002: 61 (2) s.111-113, tab., bibliogr. 14 poz.
    Sygnatura GBL: 301,720

    Hasła klasyfikacyjne GBL:
  • endokrynologia
  • pediatria

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca doświadczalna

    Wskaźnik treści:
  • ludzie
  • dzieci 13-18 r.ż.
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: The aim of the study was to compare the size, weight, volume and density of the pineal gland in several groups divided by age, body weight and height. 80 human pineal glands were included in the study. Obtained data were statistically analysed by means of Statistica by Statsoft to check existing differences. Obtained data show some significant differences between pineal gland morphometry in weight- and height-related groups. However, these differences do not influence pineal volume significantly. Differences between the pineal gland volume in the maximal and in the minimal weight groups may suggest some relationship between the gland's structure and body weight. No age-related changes in the morphometry of the pineal gland were observed.


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    Tytuł oryginału: Synthesis and biological activity of strongly fluorescent tricyclic analogues of acyclovir and ganciclovir.
    Autorzy: Goslinski Tomasz, Golankiewicz Bożenna, De Clercq Erik, Balzarini Jan
    Źródło: J. Med. Chem. 2002: 45 (23) s.5052-5057, il., tab., bibliogr. 13 poz.
    Sygnatura GBL: 312,133

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Streszczenie angielskie: In search of strongly fluorescent tricyclic analogues of acyclovir (ACV, 1) and ganciclovir (GCV, 2) derivatives of the 3,9-dihydro-9-oxo-5H-imidazo[1,2-ŕ]purine system, several 6-[4-(acyloxy)-phenyl], 6-[4-(acylamino)phenyl], and 6-[4-(phenoxycarbonyloxy)phenyl]-substituted TACV and TGCV analogues were synthesized and evaluated for their activity against herpes simplex virus types 1 and 2 in cell culture. All TACV and TGCV analogues showed strong fluorescence (quantum yield of 30-65 p.c. vs 2-aminopurine 100 p.c.). The 6-[4-(phenoxycarbonyloxy)phenyl]-substituted compounds 11 and 19 displayed the best combination of the fluorescence and antiviral potency.

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