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GEORGIADES
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Tytuł oryginału:
Colostrinin proline-rich polypeptide complex from ovine colostrum - a long-term study of its efficacy in Alzheimer's disease.
Autorzy:
Leszek
Jerzy,
Inglot
Anna D.,
Janusz
Maria,
Byczkiewicz
Franciszek,
Kiejna
Andrzej,
Georgiades
Jerzy,
Lisowski
Józef
Źródło:
Med. Sci. Monitor 2002: 8 (10) s.PI93-PI96, tab., bibliogr. 26 poz.
Sygnatura GBL:
313,278
Hasła klasyfikacyjne GBL:
toksykologia
farmacja
neurologia
Typ dokumentu:
praca kliniczna
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
dorośli 45-64 r.ż.
dorośli = 65 r.ż.
płeć męska
płeć żeńska
Streszczenie angielskie:
Background: Colostrinin, a proline-rich polypeptide complex (PRP) isolated from ovine colostrum, with immunoregulatory and procognitive properties, has shown positive effects in the treatment of Alzheimer's disease (AD). The aim of the present study was to evaluate the effects fo long-term Colostrinin treatment of AD patients. Material/Methods: The patients were taking Colostrinin tablets (containing 10 ćg of PRP complex) every other day for three weeks, followed by a 2-weeks hiatus to avoid the development of hyporeactivity. This mode of applicaton, '3+2 weeks', and each patient was evaluated at 4-month intervals, 33 patients were treated for 16 months. however, 14 patients from this group had already been treated with Colostrinin for 12 months during placebo-controlled studies, and thus participated in the trial for a total of 28 months. Results: Teh results we obtained showed that Colostrinin induced slight but statistically significant imporvement or stabilization fo teh health status of teh patients in the trial. THe adverse reactions observed, if any, were remarkably mild, including anxiety, logorrhea, and insomnia, and subsided spontaneously within a short period of tiem (3 - 4 days). Conclusions: Colostrinin is a very promising preparation which can be used to retard the development of AD.
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