Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Tytuł oryginału: Ultrastructural studies of experimental scrapie and Creutzfeldt-Jakob disease in hamsters. [P.] 1: Alterations of myelinated axons.
Autorzy: Liberski Paweł P., Bratosiewicz-Wąsik Jolanta, Gajdusek D. Carleton, Brown Paul
Źródło: Acta Neurobiol. Exp. 2002: 62 (3) s.121-129, il., bibliogr. s. 127-129
Sygnatura GBL: 302,090

Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • chomiki

    Streszczenie angielskie: Classical and ultrastructural neuropathology of prion diseases are generally well described. Here we report that alternations of myelinated fibres in hamsters infected either with polioencephalopathic strains of scrapie or panencephalopathic strains of CJD (Echigo-1) are virtually identical and differ only quantitatively. In contrast, mice infected with the panencephalopathic Fujisaki strain of CJD exhibited much more elaborate changes of myelinated fibres.

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    Tytuł oryginału: Ultrastructural studies of experimental scrapie and Creutzfeldt-Jakob disease in hamsters. [P.] 2: Astrocytic and macrophage reaction towards axonal destruction.
    Autorzy: Liberski Paweł P., Bratosiewicz-Wąsik Jolanta, Gajdusek D. Carleton, Brown Paul
    Źródło: Acta Neurobiol. Exp. 2002: 62 (3) s.131-139, il., bibliogr. s. 137-139
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • chomiki
  • Świnki morskie

    Streszczenie angielskie: We report hare the microglial (macrophage) and astrocytic reaction in several models of transmissible spongiform encephalopathies (TSEs) or prion diseases. With the low power electron microscopy it was readily apparent that myelinated vacuoles were surrounded by cells and their processes. The latter belonged either to hyperplastic reactive astrocytes or to macrophages. Typically, reactive astrocytes exhibited cytoplasm filled with innumerable glial filaments and, occasionally, other organelles (like cilia) and abundant tortuous intercellular junctions of adhesive plaque junction type. Desmosome-like junctions connecting astrocytic elements were also seen. As described earlier, astrocytic process were occasionally interdigitated with oligodendroglial cells and their processes. Two types of macrophages were readily described. The majority of them exhibited electron-dense cytoplasm and numerous "empty" vacuoles (digestive chambers) containing cellular debris. Occasional vacuoles were surrounded by a thin collar reminiscent of "lyre-like inclusions" of the second type of macrophages. Several mylinated fibres were clearly engulfed by the cytoplasm of a macrophage containing unusual annulate lamellae.

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    Tytuł oryginału: How do neurons degenerate in prion diseases or transmissible spongiform encephalopathies (TSEs): neuronal autophagy revisited.
    Autorzy: Liberski Paweł P., Gajdusek D. Carleton, Brown Paul
    Źródło: Acta Neurobiol. Exp. 2002: 62 (3) s.141-147, il., bibliogr. s. 145-147
    Sygnatura GBL: 302,090

    Hasła klasyfikacyjne GBL:
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • chomiki

    Streszczenie angielskie: As in other neurodegenerative diseases such as Alzheimer's disease, neurons in prion diseases or transmisible spongiform encephalopathies (TSEs) die via programmed cell death of which the apoptotic process is relatively well characterized. A subcellular alteration linked to apoptosis is the formation of autophagic vacuoles, which we and others demonstrated in CJD- and scrapie-affected rodent brains. Autophagy may co-exist with apoptosis or may precede it and the process may be induced by apoptosis stimuli. Here, we extend these observations using different model of scrapie and CJD. Both scrapie models (the 265K and 22C-H) demonstrated autophagic vacuoles with the same frequency; hence, they will be described together. While the following changes had been observed simultaneously in different areas of the same sample, this description is organised as if it followed a sequence of events. First, a part of the neuronal cytoplasm was sequestrated by concentric arrays of membrane; that part of the cytoplasm closed by membranes appeared relatively normal but its density often appeared increased. Next, electron density of the central dramatically increased. Then, membranes proliferated within the cytoplasm in a labyrinth-like manner and an area sequestrated by these membranes enlarged and became more complex structure consisting of vacuoles, electron-dense area and areas of normally-looking cytoplasm connected with convoluted membranes. Finally, a large area of the cytoplasm was transformed into a collection of autophagic vascuoles of different sizes. Virtually identical alternations, albeit with much lower frequency, were seen in terminally ill CJD-affected hansters.

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