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Tytuł oryginału:
Effective tumor immunotherapy: start the engine, release the brakes, step on the gas pedal, ... and get ready to face autoimmunity.
Autorzy:
Tirapu
Inigo,
Mazzolini
Guillermo,
Rodriguez-Calvillo
Mercedes,
Arina
Ainhoa,
Palencia
Belen,
Gabari
Izaskun,
Malero
Ignacio
Źródło:
Arch. Immunol. Ther. Exp. 2002: 50 (1) s.13-18, bibliogr. 62 poz.
Sygnatura GBL:
304,223
Hasła klasyfikacyjne GBL:
immunologia
onkologia
Typ dokumentu:
tytuł obcojęzyczny
Wskaźnik treści:
ludzie
zwierzęta
myszy
Streszczenie angielskie:
Cellular immune responses can destory cancer cells, achieving the cure of experimental malignancies. An exapanding wealth of knowledge on the molecular basis of how to prime and amplify a T cell response has fueled a number of strategies successful at treating estabilished tumors (rather than merely preventing tumor grafting). The most efficacious approaches operate at different stages, including: 1) priming the immune response using tumor antigen-expressing dendritic cells or tumor cells transfected with genes that render them immunogenic, 2) sustaining and amplifying immunity using agonistic monoclonal antibodies against costimulatory molecules or immune-potentiating cytokines, and 3) eliminating mechanisms that self-regulate the strenght of the immune response, such as inhibitory receptors or regulatory T cells. A rational combination of such approaches holds great hope for cumulative and synergistic effects, but there is also evidence that they can open the flood-gates for unwanted inflammatory reactions. The next decade can be envisioned as the time when the first reproducibly efficacious combination regimes for cancer immunotherapy will become available and videly used in the clinic, as clinicians learn the best strategies and try to harness their potentially damaging effects.
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