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Tytuł oryginału: Leptin and estradiol as related to change in pubertal status and body weight.
Autorzy: Larmore Kimberly A., O'Connor Darlise, Sherman Tami Irwin, Funanage Vicky L., Hassink Sandra G., Klein Karen Oerter
Źródło: Med. Sci. Monitor 2002: 8 (3) s.CR206-CR210, il., tab., bibliogr. 27 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • pediatria
  • ginekologia i położnictwo

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • płeć żeńska

    Streszczenie angielskie: Background: Previous studies have examined the relationship between leptin, body mass, and pubertal status. The present study directly compares the relationship of leptin and estradiol in 5 groups of girls with different combnations of pubertal status and weight. Material/Methods: We studied girls with idiopathic precocious puberty, age-matched non-obese prepubertal girls, age-matched obsese prepubertal girls, normal pubertal girls, and obese pubertal girls (n = 12/group). Results: Leptin levels were significantly higher in obese pubertal girls (26.6 ń 8.4 ng/mL) than in all others. Leptin levels were signifcantly higher in obese prepubertal girls (20.7 ń 10.9 ng/mL) (mean ń SD) compared to girls with precocious puberty (7.7 5.4 ng/mL, p 0.004), non-obese prepubertal girls (5.55 ń 3.6 ng/mL, p 0.001), and normal pubertal girls (4.8 ń 2.9 ng/mL, dard deviation score), which corrects leptin level for gender, pubertal stage, and BMI, was significantly lower in the obese pubertal group than in the 3 non-obese groups. Conclusions: These findings confirm previous studies that body mass, chronolgoical age and pubertal stage are determinants of leptin level. However, these are not the only factors determining leptin level as evidenced by persistent differences in leptin level between obese and non-obese pubertal girls even when correcting for pubertal stage and BMI. While the present study provides no new answers to the question of pubertal regulation, it provides a direct comparison of combination weight, pubertal stage, and leptin level, as background for future studies.

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