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FRENOUX
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Tytuł oryginału:
Very high alpha-tocopherol diet diminishes oxidative stress and hypercoagulation in hypertensive rats but not in normotensive rats.
Autorzy:
Frenoux
Jean-Marie R.,
Noirot
Beatrice,
Prost
Emmanuelle D.,
Madani
Sihem,
Blond
Jean Paul,
Belleville
Jacques L.,
Prost
Josiane L.
Źródło:
Med. Sci. Monitor 2002: 8 (10) s.BR401-BR407, tab., bibliogr. 34 poz.
Sygnatura GBL:
313,278
Hasła klasyfikacyjne GBL:
farmacja
kardiologia
Typ dokumentu:
badanie porównawcze
praca doświadczalna
tytuł obcojęzyczny
Wskaźnik treści:
zwierzęta
szczury
Streszczenie angielskie:
Background: Oxidative stress is closely related to cardiovascular diseases, suchas atherosclerosis. Increasing dietary antioxidants, such as ŕ-tocopherol, may prevent these diseases. However, in some pathologies, such as hypertension, oxidative stress is enhanced, thus ŕ-tocopherol requirements may be raised. Material/Methods: In eleven-week-old spontaneously hypertensive rats and normotensive Wistar Kyoto rats, we investigated the effects of a four-week very high ŕ-tocopherol dietary enrichment (1200 mg/kg diet, VH) on blood pressure, resistance to free radical aggression, and VLDL+LDL resistance to lipid peroxidation. Platelet aggregation and plasma lipid profile were also investigated. Results: With either diet, hypertensive rats were more protected against oxidative stress than normotensive rats. Their capacity to withstand free radical aggression was better, and their WLDL+LDL particles were less sensitive to lipdid peroxidation. In either group, the VH diet did not modify blood pressure values when resistance to free radical aggression was incrased, but not the resistance of VLDL+LDL to lipid peroxidation. With the control diet, platelet aggregation was fastsesr and higher in hypertensive rats vs. normotensive rats. It was decreased with the VH diet in hyeprtensive rats but increased in normotensive rats, when compared to their respective controls. Whatever the diet, plasma triacylglycerol, phospholipid and cholesterol concentrations were lower in hypertensive than in normotensive rats. Only cholesterol concentrations were diminished with the VH diet in hypertensive rats, but not in normotensive rats. Conclusion: These results indicate that very high ŕ-tocopherol dietary amounts decrease cardiovascular risk in hypertensive rats with high oxidative stress, but have less effect on normotensive rats.
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