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Tytuł oryginału: Effect of cerebral ventricles perfusion with morphiceptin and met-enkephalin on trigeminohypoglossal reflex in rats.
Autorzy: Zubrzycka M., Fichna J., Janecka A.
Źródło: J. Physiol. Pharmacol. 2002: 53 (4 p. 2) s.741-750, il., bibliogr. 30 poz.
Sygnatura GBL: 302,092

Hasła klasyfikacyjne GBL:
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: Opioids administered by intracerebroventricular injections produce analgesie responses in rats. The present study was undertaken to investigate the effects of a highly selective ć-opioid receptor ligand morphiceptin on trigemino-hypoglossal reflex in rats. The analgesic effect of morphiceptin was compared with another opioid peptide, Met-enkephalin. With the experimental settings used in the study, we have demonstrated that both morphiceptin and Met-enkephalin show significant dose-dependent analgesic effects after i.c.v. administration in rats as assayed by trigemino-hypoglossal reflex test. The antinonciceptive response to Met-enkephalin was short lasting and was observed 10 to 15 min after i.c.v. perfusion. Morphiceptin had a relatively longer duration of antinociceptive action, the effect was observed 20-50 min after i.c.v. perfusion. Neither morphiceptin nor Met-enkephalin produced antinociception after peripheral injections. The results of the present study indicate that both tested peptides act at ć-opioid receptors situated in the central nervous system. They also suggest that ć-opioid receptors present in the central nervous system are an important element of the trigemino-hypoglossal reflex arc. For that reason selective ć-opioid receptor ligands, like morphiceptin, inhibit the reflex more significantly.

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