Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: ESCHER
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Tytuł oryginału: Effects of acute hypoxemia/ischemia on EEG and evoked responses at normothermia and hypothermia in humans.
Autorzy: Stecker Mark M., Escherich Alison, Patterson Terry, Bavaria Joseph E., Cheung Albert T.
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR223-CR228, il., tab., bibliogr. 25 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Hypothermia is used clinically to prevent neurologic injury but the degree of protection which it affords at various levels of the nervous system in humans is difficult to establish. Material/Methods: The temporal changes in EEG amplitude and somatosensory evoked potential (SEP) amplitudes in a patient experiencing acute normothermic hypoxemia, a patient experiencing acute circulatory arrest at moderate hypothermia and a collection of patients undergoing deep hypothermic circulatory arrest were analyzed to determine the rate at which changes occur during acute lack of oxygen delivery at various temperatures. Results: In each case, it was found that more rostrally geneated potentials disappeared more quickly than more peripheral potentials. All potentials decayed more slowly during acute normothermic hypoxemia than during circualtory arrest. During circulatory arrest at 14.4řC, the amplitude of the Erb's point, 13 and N18 potentials in th SEP took 5 times longer to drop to 50 p.c. of their value at the onset of ischemia than with circulatory arrest at 30.9řC. Conclusions: The longer times to disappearance of the SEP potentials during deep hypothermia compared to moderate hypotheramia was consistent with the predicted 3.5 - 6.5 fold reduction in metabolic activity at deep hypothermia compared to moderate hypothermia. The prolonged time to disappearance of the SEP during normothermic hypoxemia demonstrates that even with reduced oxygen delivery the continued delivery of metabolic substrate can be critical to neural function.

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    Tytuł oryginału: Digital image analysis system for the quantification of infiltrates and cell adhesion molecules in inflammatory cardiomyopathy.
    Autorzy: Noutsias Michel, Pauschinger Matthias, Ostermann Karsten, Escher Felicitas, Blohm Jan-Henrik, Schultheiss Heinz-Peter, Khl Uwe
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.MT59-MT71, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: We attempted to develop a digital image analysis (DIA) system for endomyocardial biopsies (EMBs) to reliably quantify a) biopsy quality, b) immunohistochemically-marked infiltrates, and c) cell adhesion molecules (CAMs) in relation to net heart area (HA) for the semi-automated diagnosis of inflammatory cardiomyopathy (InfCM). 140 EMBs from dilated cardiomyopathy (DCM) patients and 14 autopsy heart samples (controls) were immunostained for T-lymphocytes (CD2, CD3, CD4, CD8), á2-integrin + infiltrates (CD18, LFA-1, Mac-1) and CAMs (immunoglobulin superfamily: ICAM-1, HLA class I, HLA DR, VCAM-1, CD58; selectins: CD62E and CD62P; and the á1-integrin chain CD29). EMB quality was assessed visually on a three-point scale. Infiltrates were quantified visually (per hpf) and by DIA (per mm2 HA). CAM expression was evaluated semiquantitatively and bay DIA (area fraction [AF]: stained area relative to HA). DIA-evaluated HA correlated significantly with the visual assessment of EMB quality. The visual evaluation of both infiltrates and CAMs correlated significantly with the respective DIA-based quantification. DIA-quantified CAM-AF and infiltrates were discriminated bay the CAM clssification (CAMs+: n = 87; 62 p.c.) compared to controls. DIA-quantified cCAM immunoreacativity correlated significantly with the DIA-quantified counter-receptor + infiltrates. DIA evaluation of biopsy quality, infiltrates, and CAMs was devoid of inter- and intraobserver variability. The DIA system presented here enables standardized and observer-independent assessment of EMB quality and intramyocardial...

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