Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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1/5

Tytuł oryginału: Effects of acute hypoxemia/ischemia on EEG and evoked responses at normothermia and hypothermia in humans.
Autorzy: Stecker Mark M., Escherich Alison, Patterson Terry, Bavaria Joseph E., Cheung Albert T.
Źródło: Med. Sci. Monitor 2002: 8 (4) s.CR223-CR228, il., tab., bibliogr. 25 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kazuistyczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: Hypothermia is used clinically to prevent neurologic injury but the degree of protection which it affords at various levels of the nervous system in humans is difficult to establish. Material/Methods: The temporal changes in EEG amplitude and somatosensory evoked potential (SEP) amplitudes in a patient experiencing acute normothermic hypoxemia, a patient experiencing acute circulatory arrest at moderate hypothermia and a collection of patients undergoing deep hypothermic circulatory arrest were analyzed to determine the rate at which changes occur during acute lack of oxygen delivery at various temperatures. Results: In each case, it was found that more rostrally geneated potentials disappeared more quickly than more peripheral potentials. All potentials decayed more slowly during acute normothermic hypoxemia than during circualtory arrest. During circulatory arrest at 14.4řC, the amplitude of the Erb's point, 13 and N18 potentials in th SEP took 5 times longer to drop to 50 p.c. of their value at the onset of ischemia than with circulatory arrest at 30.9řC. Conclusions: The longer times to disappearance of the SEP potentials during deep hypothermia compared to moderate hypotheramia was consistent with the predicted 3.5 - 6.5 fold reduction in metabolic activity at deep hypothermia compared to moderate hypothermia. The prolonged time to disappearance of the SEP during normothermic hypoxemia demonstrates that even with reduced oxygen delivery the continued delivery of metabolic substrate can be critical to neural function.

    2/5

    Tytuł oryginału: Proinflammation: A common denominator or initiator of different pathophysiological disease processes.
    Autorzy: Esch Tobias, Stefano George B.
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.HY1-HY9, il., bibliogr. 85 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Proinflammation is a widespread phenomenon. It has an association with the stress (patho)physiology and is connected with various diseases. Recently, it has been discussed if proinflammation may represent a common (pre)condition in defferent disease states. Evidence for a common proinflammatory pattern in a variety of diseases is analyzed. Proinflammatory (pre)conditions and immune response patterns serve as a common modality in a number of clinically separate diseases. Here, nitric oxide pathways often play a significant role as well. On molecular basis, proinflammation potentially illustrates a common denominator and/or an initiator. Like stress, proinflammation seems to be crucial autoregulatory concept. It normally serves a positive biological goal: Proinflammatory activities, e.g., are initiated to overcome infection or invasion of potentially deleterious biological agents (bacteria, viruses, parasites etc.). While fighting invasion, proinflammation usually shortens biological 'battles' and therefore ameliorates disease-related detrimental or subjectively unpleasing phenomena. However, proinflammation has beneficial and deteriorating capacities and may yet exert detrimental effects. This is especially true, when the fine balance between the different immune response pathways, between anti- and proinflammatory mechanisms, can not be kept. This may occur when a challenge becomes overwhelming or when paterns of a chronic (patho)physiological activity are presented. Thus, proinflammation may represent a relatively unspecific, overlapping/analogous state, underlying various clinical disease manifestations.

    3/5

    Tytuł oryginału: Digital image analysis system for the quantification of infiltrates and cell adhesion molecules in inflammatory cardiomyopathy.
    Autorzy: Noutsias Michel, Pauschinger Matthias, Ostermann Karsten, Escher Felicitas, Blohm Jan-Henrik, Schultheiss Heinz-Peter, Khl Uwe
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.MT59-MT71, il., tab., bibliogr. 27 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: We attempted to develop a digital image analysis (DIA) system for endomyocardial biopsies (EMBs) to reliably quantify a) biopsy quality, b) immunohistochemically-marked infiltrates, and c) cell adhesion molecules (CAMs) in relation to net heart area (HA) for the semi-automated diagnosis of inflammatory cardiomyopathy (InfCM). 140 EMBs from dilated cardiomyopathy (DCM) patients and 14 autopsy heart samples (controls) were immunostained for T-lymphocytes (CD2, CD3, CD4, CD8), á2-integrin + infiltrates (CD18, LFA-1, Mac-1) and CAMs (immunoglobulin superfamily: ICAM-1, HLA class I, HLA DR, VCAM-1, CD58; selectins: CD62E and CD62P; and the á1-integrin chain CD29). EMB quality was assessed visually on a three-point scale. Infiltrates were quantified visually (per hpf) and by DIA (per mm2 HA). CAM expression was evaluated semiquantitatively and bay DIA (area fraction [AF]: stained area relative to HA). DIA-evaluated HA correlated significantly with the visual assessment of EMB quality. The visual evaluation of both infiltrates and CAMs correlated significantly with the respective DIA-based quantification. DIA-quantified CAM-AF and infiltrates were discriminated bay the CAM clssification (CAMs+: n = 87; 62 p.c.) compared to controls. DIA-quantified cCAM immunoreacativity correlated significantly with the DIA-quantified counter-receptor + infiltrates. DIA evaluation of biopsy quality, infiltrates, and CAMs was devoid of inter- and intraobserver variability. The DIA system presented here enables standardized and observer-independent assessment of EMB quality and intramyocardial...

    4/5

    Tytuł oryginału: Stress in cardiovascular diseases.
    Autorzy: Esch Tobias, Stefano George B., Fricchione Gregory L., Benson Herbert
    Źródło: Med. Sci. Monitor 2002: 8 (5) s.RA93-RA101, il., bibliogr. 85 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Evidence for a connection between stress and selected cardiovascular diseases is analyzed. Does stress cause or exacerbate cardiovascular diseases? The stress phenomenon is illustrated and the impact of stress on the circulatory system is examined. In particular, the pathophysiological significance of stress in hypertension, atherosclerosis, coronary artery disease, myocardial infarction (and others) is described. Stress plays a major role in various (pathophysiological processes associated with the circulatory system. Thereby, it potentially has ameliorating or detrimental capacities. However, with regard to cardiovascular disease, stress most often is related to deleterious results. The specific outcome depends on multiple variables (amount of stress, duration of is influence, patient's history/predisposition, genetic components - as they all may after functions of the basic stress response components: the hypothalmic-pituitary-adrenal axis and the sympathoadrenal medullary system). Stress has a major impact upon the circulatory system. It plays a significant role in susceptibility, progess, and outcome of cardiovascular diseases. Subjective or individual differences have also to abe taken into account. Stress, especially 'adequate'acute stress - stress that is not 'overwhelming' - may improve performance and thus be beneficial in certain cases. The close relationship between stress and cardiovascular diseases may represent an important aspect of modern medicine. New therapeutic strategies have to be set in place.

    5/5

    Tytuł oryginału: Stress-related diseases - a potential role for nitric oxide.
    Autorzy: Esch Tobias, Stefano George B., Fricchione Gregory L., Benson Herbert
    Źródło: Med. Sci. Monitor 2002: 8 (6) s.RA103-RA118, tab., bibliogr. 195 poz.
    Sygnatura GBL: 313,278

    Hasła klasyfikacyjne GBL:
  • immunologia
  • kardiologia
  • neurologia

    Typ dokumentu:
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Nitric oxide (NO) is involved in stress physiology and stress-related disease processes. Like stress, NO seems to be capable of principally exerting either beneficial or deleterious effects. The actual distinction depends on a multitude of factors. Moreover, NO conteracts norepinephrine (NE) activity and sympathetic responsivity. Thus, NO and the stress (patho)physiology are closely connected ad molecular mechanisms or pathways may be shared under certain conditions. NO is involved in immunological, cardiovascular, and neurodegenerative diseases/mental disorders. It represents a 'double-edged sword', since small quantities produced by constitutive enzymes may predominantly mediate physiological effects, whereas the expression of inducible NO synthases may lead to larger quantities of NO, a situation that may be associated with cytotoxic and detrimental effect of NO. The key step for normally useful physiological mechanisms beacoming pathophysiological may be represented by the loss of balance, the loss of control over the different pathways induced. A failure to terminate or shift originally protective mechanisms may lead to a vicious cycle of disease-supporting pathophysiological pathways. Profound connections between stress and various disease processe exist. Thereby, common pathophysiological pathways in stress-related diseases have been described, ant they involve stress hormone (cortisol, NE) and, in particular, NO activity. Thus, NO has detrimental capacities. However, NO not only exerts deleterious but also strongly ameliorating effects. The balance between both properties is crucial. Yet, nitric oxide involvement in stress-related disease represents a common pathway, with various pathophysiogical analogies, that may be accessible for strategies using stress mangement and relaxation response techniques.

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