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Tytuł oryginału: Gronkowce metycylinooporne: mechanizmy oporności, czynniki zjadliwości oraz metody genotypowania.
Tytuł angielski: Methicillin resistant staphylococci, mechanisms of resistance, virulence factors and methods of molecular typing.
Autorzy: Łopaciuk Urszula, Dzierżawska Danuta
Źródło: Post. Mikrobiol. 2002: 41 (4) s.401-418, bibliogr. 100 poz., sum.
Sygnatura GBL: 304,786

Hasła klasyfikacyjne GBL:
  • mikrobiologia

    Wskaźnik treści:
  • ludzie

    Streszczenie angielskie: Methicillin resistant Staphylococcus aureus is an important human pathogen. Soon after the initial introduction of penicillin for treatment of streptococcal and ataphylococcal infections it turned out that approximately 60 p.c. of Staphylococcus aureus strains were resistant to penicillin. The resistance was caused by emergence of penicillinase producing strains. In the 1960s first methicillin resistant strains of Staphylococcus aureus (MRSA) were reported. The resistanct to methicillin resulted from PBP2a synthesis encoded by mec gene. Modified penicillin-binding protreins show decrease affinity for penicillins, which leads toresistance to all antibiotics from this group. Specific structure of DNA region containing mecA gene is responsible for cross-resistance to other groups of antibiotics (e.g. macrolides, lincosamides, tetracyclines and aminoglycosides). Detection of resistance to methicillin is difficult and requires specific nethods. Currently there are many commercial tests providing quick and reliable results, however the most sensitive technique is based on detection of mecA gene. Most S. aureus infections originate from skin surface and mucous membranes. S. aureus has a lot of structures that facilitate its adherence to extracellular matrix proteins. It is widely accepted that MRSA is more virulent than MSSA and its virulence factors are a subject of interest for researcgers. MRSA is very important etiological factor of hospital infections and molecular typing methods (especially all kinds of PCRs and PFGE) have broad applications in epidemiological investigations.

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