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Tytuł oryginału: Hepatic cirrhosis increases sensitivity of kidney to endotoxin in rats.
Autorzy: Liu Jian-Jun, Wang Ji-Yao, Zhang Chi, Nilsson Ake, Duan Rui-Dong
Źródło: Med. Sci. Monitor 2002: 8 (2) s.BR56-BR60, il., bibliogr. 31 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • gastroenterologia
  • nefrologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Background: Renal failure in cirrhotic patients is a severe complication and endotoxemia might be involved. We investigated the effect of endotoxin on renal function of cirrhotic rats and the potential protective role of N-acetylcysteine (NAC). Material/Methods: Hepatic cirrhosis was generated in a rat model by carbon tetrachloride. Both cirrhotic and normal rats were insulted by endotoxin intravenously, while another cirrhotic group was pretreated with NAC. Blood urea nitrogen (BUN) and creatinine were assayed eight hours later. The changes in serum tumor necrosis factor-ŕ (TNF-ŕ) were assayed by ELISA. The histological changes in the kidney were observed after hematoxylinand eosin staining. Results: Endotoxin increased the BUN and creatinine levels in both normal and cirrhotic rats, with a much higher elevation in the latter group. TNF-ŕ concentration was also increase by endotoxin; the changes are positively correlated with BUN and creatinine. NAC pretreatment sigificantly attenuates the effects of endotoxin on BUN, creatnine and TNF-ŕ levels in cirrhotic rats with no improvement in systemic toxicity symptoms. There were no obvious histological changes in the kidney of these animals. Conclusion: Hepatic cirrhosis increased the sensitivity of renal function to endotoxemia, which may be protected by NAC.

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