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Tytuł oryginału: Effect of repeated treatment with mirtazapine on the central dopaminergic D2/D3 receptors.
Autorzy: Rogóż Zofia, Wróbel Andrzej, Dlaboga Daniel, Dziedzicka-Wasylewska Marta
Źródło: Pol. J. Pharmacol. 2002: 54 (4) s.381-389, tab., bibliogr. 42 poz.
Sygnatura GBL: 313,156

Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

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    Streszczenie angielskie: Mirtazapine (MIR) is an antidepressant drug which enhances noradrenergic and serotonergic 5-HT1A neurotransmission via antagonistic action at central ŕ2-adrenergic autoreceptors and heteroreceptors. We reported earlier that tricyclic antidepressants administered repeatedly induced adaptive changes in the central dopaminergic D2/D3 receptors. Therefore, we designed our present study to determine whether repeated MIR treatment could evoke similar effect. The experiments were carried out on male Wistar rats. MIR was administered at a dose of 10 mg/kg once or repeatedly (twice daily for 14 days). The obtained results showed that MIR administered repeatedly potentiated the hyperlocomotion induced by D-amphetamine but not by quinpirole or 7-OH-DPAT. Biochemical study showed that MIR administered repeatedly decreased the binding of [3H]quinpirole (a D2/D3 receptor agonist) in the shell part of the nucleus accumbens septi and in the islands of Calleja but did not change the binding in the nucleus caudatus (medial or lateral). On the other hand, both acute and repeated drug treatment did not change the [3H]7-OH-DPAT (a D3 receptor agonist) binding sites in the islands of Calleja as well as in the shell part of nucleus accumbens septi. In addition, MIR did not alter the level of mRNA encoding dopamine D2 receptors, not only after repeated but also after acute treatment. The above results indicate that repeated MIR administration did not induce any adaptive change (behavioral and biochemical changes) in the dopaminergic D2/D3 system.

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    Tytuł oryginału: Effect of repeated treatment with mirtazapine on the central ŕ1-adrenergic receptors.
    Autorzy: Rogóż Z[ofia], Wróbel A., Dlaboga D., Dziedzicka-Wasylewska M.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (1) s.105-116, tab., bibliogr. 38 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury

    Streszczenie angielskie: Mirtazapine (MIR) is an antidepressant which enhances noradrenergic and serotonergic 5-HT1A neurotransmission via antagonism of central ŕ2-adrenergic autoreceptors and heteroreceptors. The drugs does not inhibit noradrenaline and serotonin reuptake but blocks the 5-HT2 and 5-HT3 receptors and has high affinity only for central and peripheral histamine H1 receptors. The present study was was aimed at determining whether repeated MIR treatment induced adaptive changes in the ŕ1-adrenergic receptors, similar to those reported by us early for tricyclic antidepressants. The experiments were carried out on male mice and rats. MIR was administered at a dose of 10 mg/kg oce or repeatedly (twice daily for 14 days). The obtained results showed that MIR administrated repeatedly potentiated the methoxamine- induced exploratory hyperactivity in rats and clonidine-induced aggressiveness in mice, those effects being mediated by ŕ1-adrenergic receptors. MIR given repeatedly (but not acutely) increased the binding (Bmax) of [3H]prozosin to ŕ1-adrenergic receptors in cerebral cortex, however, the ability of the ŕ1-sdrenoreceptor agonist phenylephrine to compete for the these sites was not significantly changed. The above results indicate that repeated MIR administration increases the responsiveness of ŕ1-adrenergic system (behavioural and biochemical changes), as tricyclic do. However, the question whether the increased functional responsiveness found in the present study is important for the clinical antidepressant efficacy, remains open.

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    Tytuł oryginału: Effect of tianeptine and fluoxetine on the levels of Met-Enkephalin and mRNA encoding proenkephalin in the rat.
    Autorzy: Dziedzicka-Wasylewska M., Dlaboga D., Pierzchała-Koziec K., Rogóż Z[ofia]
    Źródło: J. Physiol. Pharmacol. 2002: 53 (1) s.117-125, tab., bibliogr. 42 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • genetyka
  • farmacja

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The purpose of the present study was to evaluate the effects of acute and repeated treatment with two antidepressant drugs (ADs) of opposite pharmacological profile, i.e. tianpetine (TIA, serotonin reuptake enhancer) and fluoxetine (FLU, serotonin reuptake inhibitor) on the levels of Met-Enkephalin, (Met-Enk, a member of opioid peptidefamily, which has been suggested to play a role in the mechanism of action ADs) as well as on mRNA coding for proenkephalin (mRNA PENK) in various regions of the rat brain, pituitary, drenal glands and plasma. male Wistar rats treated acutely or repeatedly (10 mg/kg p.o., twice daily for 14 days) with TIA or FLU. Tissue for biochemical experiments was taken 2 h after last dose of appropriate drug. The levels of Met-Enk were estimated by radioimmunoassay, mRNA PENK was measured using in situ hybridization. From the results obtained in the present study it may be concluded thart repeated adminiostration of TIA or FLU induced similar changes in the levels of Met-Enk in the rat hippocampus, striatum, hypothalamus and neurointermediate lobe of pituitary. Such an effect is interesting, especially if one takes into account the differences in pharmacological profile between these two antidepressant drugs. It may be suggested that serotonin level might not be crucial for inducing the alterations in the content of Met-Enk. Since we did not observe any changes in the levels of PENK mRNA in the studied rat brain regions after repeated administration of TIA or FLU, it seems that the observed changes in the levels of Met-Enk...

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