Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: DEMMELMAIR
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Tytuł oryginału: Long-chain PUFA supplementation improves PUFA profile in infants with cholestasis.
Autorzy: Socha Piotr, Koletzko Berthold, Jankowska Irena, Pawłowska Joanna, Demmelmair Hans, Stolarczyk Anna, Świątkowska Elżbieta, Socha Jerzy
Źródło: Lipids 2002: 37 (10) s.953-957, il., tab., bibliogr. 26 poz.
Sygnatura GBL: 305,815

Hasła klasyfikacyjne GBL:
  • pediatria
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • praca opublikowana za granicą
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • niemowlęta

    Streszczenie angielskie: Long-chaim PUFA (LCP) deficiency is a frequent complication in cholestic infants. We investigated the effects of LCP-supplemented formula on EFA status in infants with cholestasis. Twenty-three infants with cholestasis (biliary atresia after surgery, 8; intrahepatic cholestasis, 15) aged 1.9 to 4.9 mon (median 3.1 mon) were randomized to receive commercial infant formulas either without LCP or with LCP from egg phospholipids for 1 mon. Liver tests, nutrient intakes, and plasma phospholipid FA (p.c. w/w) were determined at baseline and after interavention. At baseline, patietns had high serum direct bilirubin levels (5.9 ń 3.0 mg/dL; mean ń SD), they were malnourished (body fat mass: 40 ń 13 p.c. of normal) and presented with PUFA deficiency [plasma phospholipid PUFA: 28.43 p.c. w/w (26.56 - 30.53) in patients vs. 37.02 p.c. w/w (34.53 - 39.58) in controls; median (f1st - 3rd quartile)] with elevated Mead acid and palmitoleic acid. LCP-supplemented (n = 11) and -nonsupplemented groups (n = 12) did not differ in age, indicators of liver function, and EFA status at baseline. After the intervention, LCP-supplemented infants had higher levels of arachidonic acid [7.2 (5.9 - 8.8) vs. 4.2 (f3.0 - 5.3) p.c. w/w; P 0.001] and DHA [2.8 (2.2 - 3.2) vs. 1.6 (1.0 - 2.1) p.c. w/w; P 0.05], accompanied by increased TBARS concentration: 1.9 (1.4 - 2.2) vs 1.3 (1.1 - 1.6) nmol/mL; P 0.05]. We concluded that LCP-supplemented formulae improve LCP status of infants with severe cholestasis but may enhance lipid peroxidation.

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