Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

Zapytanie: DEENICHIN
Liczba odnalezionych rekordów: 1



Przejście do opcji zmiany formatu | Wyświetlenie wyników w wersji do druku

1/1

Tytuł oryginału: Clinical and bacteriological results from the administration of Cefepime (Maxipime) in patients with severe sepsis.
Autorzy: Stefanov Chavdar Stefanov, Doikov Ilian, Dimov Rossen, Deenichin George, Delikostadinov George
Źródło: Med. Sci. Monitor 2002: 8 (11) s.PI97-PI102, il., tab., bibliogr. 29 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • mikrobiologia
  • toksykologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna

    Wskaźnik treści:
  • ludzie
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The aim of the present study was to investigate the clinical and bacteriological efficacy of Cefepime administered to critically ill sepsis patients, as well as possible adverse reactions and interactions. Material/methods: 30 patients with severe sepsis of different origin were treated with Cefepime a dosage of 2.0 g bid. Of these patients, 26 survived (86.67 p.c.). The clinical and bacteriological effects of antibiotic administration were recorded at the end of treatment. Results: The treatment outcomes in terms of clinical results were as follows: 17 patients cured (56.67 p.c.), 7 improved (23.33 p.c.), 2 with unsatisfacotry outcome (6.67 p.c.), and 4 failures (13.33 p.c.). Cefepime treatment resulted in a reduction of the APACHE II score from ca. 20 at the beginning to 9.44 at the end, while the SOFA score fell from 7 to 2.62. This indicates improved clinical status and reversal of multiple organ failure. The bacteriological results were as follows: pathogen eradication in 17 cases (56.6 p.c.), pathogen persistence in 8 cases (26.67 p.c.), and superinfection in 5 cases (16.66 p.c.) Out of 80 total hemocultuers, 63 proved to be sterile. In two cases in vitro ENterococcus faecium was isolated with antibiotic resistance. Of 81 total cutures of infectious foci 10 showed resistance: 4 Pseudomonas aeruginosa, 4 Acinetobacter baumanii, and 2 Enterococcus faecalis. No side effects of Cefepime administration were recorded. Conclusions: Cefepime adminsitration resulted in low mortality, clincial improvement, minimal resistance, and lack of side effects. Cefepime is an effective drug of first choice for critically ill sepsis patients.

    stosując format: