Wynik wyszukiwania w bazie Polska Bibliografia Lekarska GBL

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Tytuł oryginału: XXIV Congress of the European Society of Cardiology, Berlin, 31 sierpnia - 4 września 2002.
Autorzy: Grochowicz Urszula, Czepiel Aleksandra, Chamiec Tomasz, Rezler Joanna, Cieśliński Andrzej
Źródło: Kardiol. Pol. 2002: 57 (12) s.583-587 - 24 Kongres Europejskiego Towarzystwa KardiologicznegoSympozjum polsko-niemieckie. Jesienny Kongres Niemieckiego Towarzystwa Kardiologicznego BerlinMagdeburg 31.08-04.09.17-19.10. 20022002
Sygnatura GBL: 313,397

Hasła klasyfikacyjne GBL:
  • kardiologia

    Typ dokumentu:
  • praca związana ze zjazdem
  • sprawozdanie

    Temat korporatywny:
  • Europejskie Towarzystwo Kardiologiczne


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    Tytuł oryginału: Effects of 5-HT1B receptor ligands microinjected into the accumbal shell or core on the cocaine-induced locomotor hyperactivity in rats.
    Autorzy: Przegaliński E., Filip M., Papla I., Czepiel K.
    Źródło: J. Physiol. Pharmacol. 2002: 53 (3) s.383-394, il., bibliogr. 46 poz.
    Sygnatura GBL: 302,092

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • neurologia
  • farmacja

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca doświadczalna

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: The present study was designed to examine the effect of 5-HT1B receptor ligands microinjected into the subregions of the nucleus accumbens (the shell and the core) on the locomotor hyperactivity induced by cocaine in rats. Male Wistar rats were implanted bilaterally with cannulae into the accumbens shell or core, and then were locally injected with GR 55562 (an antagonist of 5-HT1B receptors) or CP 93129 (an agonist of 5-HT1B receptors). Given alone to any accumbal subregion, GR 55562 (0.1 - 10 ćg/side) or CP 93129 (0.1 - 10 ćg/side) did not change basal locomotor activity. Systemic cocaine (10 mg/kg) significantly increased the locomotor activity of rats. GR 55562 (0.1 - 10 ćg/side), administered intra-accumbens shell prior to cocaine, dose-dependently attenuated the psychostimulant-induced locomotor hyperactivity. Such attenuation was not found in animals which had been injected with GR 55562 into the accumbens core. When injected into the accumbens shell (but not the core) before cocaine, CP 93129 (0.1 - 10 ćg/side) enhanced the locomotor response to cocaine; the maximum effect being observed after 10 ćg/side of the agonist. The later enhancement was attenuated after intra-accumbens shell treatment with GR 55562 (1 ćg/side). Our findings indicate that cocaine induced hyperlocomotion is modified by 5-HT1B receptor ligands microinjected into the accumbens shell, but not core, this modification consisting in inhibitory and facilitatory effects of the 5-HT1B receptor antagonist (GR 55562) and agonist ...


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    Tytuł oryginału: Role of dopamine D3 receptors in controlling the expression of cocaine sensitization in rats.
    Autorzy: Filip Małgorzata, Papla Iwona, Czepiel Klaudia
    Źródło: Pol. J. Pharmacol. 2002: 54 (6) s.687-691, il., bibliogr. 27 poz.
    Sygnatura GBL: 313,156

    Hasła klasyfikacyjne GBL:
  • psychiatria i psychologia
  • farmacja
  • neurologia

    Typ dokumentu:
  • praca doświadczalna
  • tytuł obcojęzyczny
  • komunikat

    Wskaźnik treści:
  • zwierzęta
  • szczury
  • płeć męska

    Streszczenie angielskie: It is established that dopamine (DA) is an important brain mediator of the behavioral (i.e. sensitizing) effects of cocaine in rodents. Among DA receptor, recent findings point to engagement of DA D3 receptors in cocaine addictive actions. In the present study, we attempted to determine the role of DA D3 receptors in the expression phase of sensitization to cocaine in rats, using the selective ligands 7-OH-PIPAT (an agonist) and nafadotride (an antagonist) of these receptors. Repeated administration (1-5 days) of cocaine (10 mg/kg, ip) to male Wistar rats significantly enhanced the locomotor activation induced by its challenge dose given after 5-day withdrawal (on day 10). 7-OH-PIPAT (1 mg/kg, but not 0.01-0.1 mg/kg, sc) administered together with a challenge dose of cocaine significantly decreased the response to cocaine in rats treated repeatedly with cocaine. On the other hand, the expression of cocaine sensitization was increased when that drug was combined with nafadotride (0.4 mg/kg, ip) on day 10. The results indicate a role of DA D3 receptors in controlling the expression of cocaine sensitization in rats, and may suggest an importance of DA D3 receptor agonists in the therapy of cocaine abuse.

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