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Tytuł oryginału: Comparative analysis of lipid profiles assessed by ultracentrifugation in patients with various hyperlipoproteinaemia types in correlation with hepatic steatosis.
Autorzy: Tacikowski Tadeusz, Dzieniszewski Jan, Nowicka Grażyna, Ciol Janusz
Źródło: Med. Sci. Monitor 2002: 8 (10) s.CR697-CR701, tab., bibliogr. 41 poz.
Sygnatura GBL: 313,278

Hasła klasyfikacyjne GBL:
  • gastroenterologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • dorośli 45-64 r.ż.
  • płeć męska
  • płeć żeńska

    Streszczenie angielskie: Background: The purpose of our study was to compare lipid profile assessed by ultracentrifugation in various types fo hyperlipoproteinemia (HLP) in correlation with obesity and hepatic steatosis diagnosed in the ultrasonic examination of the abdominal cavity. Material/Methods: We studied 64 patients (38 women adn 26 men with a mean age of 53.5 years) with various types of HLP, divided into two groups: 1) hypercholesterolemia, 2) mixed hyperlipoproteinemia. Lipid profile by ultacentrifugation was performed simultaneously with ultrasonic examination. Results: Among 33 patients with hypercholoesterolaemia, 7 had hepatic steatosis (21.2 p.c.), with a mean serum TG concentraation significantly higher than in those patients without steatosis. Of the mixed HLP patients, 16 had hepatic steatosis (51.5 p.c.), with a mean serum TG level over twice the concentration found in patients without steatosis. We found significantly higher levels of total cholesterol adn triglycerides in patients with steatosis than in those without. In the HDL fraction, the cholesterol concentration was lower (38.4 mg/dl) in cases of steatosis than in cases without (48.0 mg/dl). Conclusions: Patients with steatosis showed features characteristic of insulin resistance syndrome, i.e. higher BMI values, higher mean serum TG, and low HDL cholesterol concentrations. In patients with hypercholesterolemia and hepatic steatosis, increased serum triglycerides are associated with increased TG concentration in the VLDL fraction. Mixed HLP patients with hepatic steatosis have higher TG adn cholesterol in the VLDL fraaction, adn in these cases a significant rise in total TG is observed.

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