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Tytuł oryginału: Late-onset neonatal sepsis - diagnostic usefulness of procalcitonin, C-reactive protein and immature to total neutrophils ratio.
Autorzy: Korczowski Bartosz, Chrząstek-Spruch Hanna, Błaszkiewicz Paweł
Źródło: Arch. Perinat. Med. 2002: 8 (2) s.28-30, il., tab., bibliogr. 20 poz.
Sygnatura GBL: 306,526

Hasła klasyfikacyjne GBL:
  • pediatria
  • mikrobiologia

    Typ dokumentu:
  • praca kliniczna
  • tytuł obcojęzyczny

    Wskaźnik treści:
  • ludzie
  • noworodki

    Streszczenie angielskie: Procalcitonin (PCT) is a new marker of severe bacterial infection. To compare the clinical usefulness of PCT, C-reactive protein (CRP) and white blood count with differential in the diagnosis of late-onset neonatal sepsis was the aim of the study. One hundred twenty nine newborns older than 3 days were included into the study and divided into 3 groups: group A - 61 newborns with sepsis; group B - 46 babies with local infections, group C - 22 newborns with severe distress but no infection. For comparison 30 healthy controls older 3 days were enrolled into the study - group D. Determinations of CRP concentration and PCT and white blood count with differential were performed on admission or at the moment when previously stable condition of the newborn deteriorated. Sensitivity, specificity, negative and positive predictive values for two different cut-off points for each parameter were calculated. At a cut-off value of 0.5 ng/ml for PCT and 0.5 mg/dl for CRP these parameters detected septic newborns with a sensitivity of 97 p.c. and 49 p.c. and specificity of 75 p.c. and 60 p.c. If cut-off points of 1.0 ng/ml and 1.0 mg/dl were used. PCT also had higher sensitivity (85 p.c.) and specificity (91 p.c.) than CRP (sensitivity - 38 p.c., specificity - 85 p.c.). I/T ratio 0.2 was specific for sepsis (100 p.c.) but low sensitivity (12 p.c.) limits it's usefulness. I/T ratio achieved better sensitivity (49 p.c.) but it's specificity dropped to 88 p.c. PCT comparing to CRP and I/T ratio is more reliable marker in the diagnosis of late-onset neonatal sepsis.

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