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Tytuł oryginału: Osteoprotegerin and sRANKL serum levels in multiple myeloma patients.
Autorzy: Centkowski Piotr, Kraj Maria, Kruk Barbara, Sokołowska Urszula
Źródło: Centr. Eur. J. Immunol. 2002: 27 (4) s.129-135, il., tab., bibliogr. 31 poz.
Sygnatura GBL: 313,243

Hasła klasyfikacyjne GBL:
  • hematologia
  • onkologia

    Typ dokumentu:
  • tytuł obcojęzyczny
  • praca kliniczna
  • praca związana ze zjazdem

    Wskaźnik treści:
  • ludzie
  • płeć męska
  • płeć żeńska
  • dorośli 19-44 r.ż.
  • dorośli 45-64 r.ż.
  • dorośli = 65 r.ż.

    Streszczenie angielskie: Beckground: Receptor activator of NF-kappaB (RANK) is a TNF receptor superfamily member expressed on the surface of osteoclasts and their precursors that mediates their differentation, survival, and activation upon interaction with its ligand, RANKL, expressed by osteoblasts, stromal cells and multiple myeloma (MM) plasma cells, RANKL is produced as a membrane bound protein and cleaved into a soluble form by a metalloprotease. The primary secreted form is produced by activated T-lymphocytes. Osteoprotegerin (OPG) is a secreted TNFR, it acts as a decoy receptor for RANKL and inhibitor of RANK-RANKL interaction. Recent studies suggest that MM triggers osteoclastogenesis by disrupting the balance between RANKL and its natural inhibitor, OPG. Therefore in this study we analyzed the concentrations of serum OPG and sRANKL in MM patients at diagnosis. Material and methods: Determinations of serum OPG and sRANKL concentrations were performed in 25 healthy subjects and 44 MM patients (6 at stage I, 2 - II, 29 - IIIA, 7 - IIIB acc. to DS.m 33 had lytic lesions at skeletal X-ray survey; monoclonal protein IgG was in 33 patients, IgA - 6, Bence Jones - nonsecretory - 1) bymeans of ELISA method using Osteoprotegerin Elisa and sRANKL ELISA kits (Biomedica, GmbH, Vienne, Austria). Results: In the whole group of MM patients, OPG concetration in particular patients ranged from 42 to 346 pg/ml with a mean concentration of 111 ń 69, median 88 pg/ml while in healthy age - and sexmatched controls OPG levels ranged from 49 to 130 pg/ml, mean 77 ń 22, median 74 pg/ml (p = 0,0208)...

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