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Tytuł oryginału: Predictive assay for adverse health outcomes in molecular epidemiology.
Autorzy: Cebulska-Wasilewska Antonina
Źródło: Prz. Epidemiol. 2002: 56 supl.: Conference on molecular epidemiology in preventive medicine - achievements and new challenges s.163-175, il., tab., bibliogr. 18 poz. - Konferencja pt. Molekularna epidemiologia w medycynie prewencyjnej - osiągnięcia i nowe wyzwania Kraków 20-22.06. 2002
Sygnatura GBL: 301,250

Hasła klasyfikacyjne GBL:
  • genetyka

    Typ dokumentu:
  • praca związana ze zjazdem
  • tytuł obcojęzyczny

    Streszczenie angielskie: There is continuously increasing concern about exposure of individuals to hazardous chemicals or physical agents and the possible resultant effects on human health. Chromosome aberrations as structural or numerical chromosome changes, resulting from direct DNA breakage or from inhibition of DNA repair or synthesis, measured in peripheral blood lymphocytes have been used in occupational health surveillance programs in order to assess genotoxic risks. The concept for this biomarker assumes that the extent of genetic damage in peripheral lymphocytes reflects similar events in the precursor cells for carcinogenic processes. In the first cellular division the frequencies of unstable chromosome aberrations (dicentrics, rings fragments) and stable chromosome aberration - translocations (analyzed with FISH technique) are often studied for the purpose of retrospective biological dosimetry, in the second cellular division sister chromatid exchanges and high frequency cells. Discussed here results of cytogenetic damage detected in a monitoring studies have shown the association with adverse health outcome and the influence of confounding factors related to the life style. Susceptibility to the activity of environmental agent was evaluated in studies on variation between responses to challenging dose of UV or X-rays followed by the evaluation of the repair capacity of the damage induced by a challenging dose. The induced and residual damage was detected with the use of the DNA damage analysis by single cell gel electrophoresis ...

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